Elucidation of the mechanism of urinary stone formation in metabolic syndrome and its application to molecular target treatment

• Project/Area Number: 15H04976
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Nagoya City University
• Principal Investigator: Okada Atsushi 名古屋市立大学, 大学院医学研究科, 准教授 (70444966)
• Co-Investigator(Kenkyū-buntansha): 安井 孝周 名古屋市立大学, 大学院医学研究科, 教授 (40326153) ; 安藤 亮介 名古屋市立大学, 医学(系)研究科(研究院), その他 (30381867) ; 田口 和己 名古屋市立大学, 医学(系)研究科(研究院), 研究員 (00595184) ; 戸澤 啓一 名古屋市立大学, 大学院医学研究科, 教授 (40264733) ; 郡 健二郎 名古屋市立大学, その他部局等, 学長 (30122047)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000); Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
• Keywords: 尿路結石 / メタボリックシンドローム / オステオポンチン / マクロファージ / 白色脂肪細胞 / ベージュ細胞 / 抗オステオポンチン抗体 / β3作動薬 / 褐色脂肪組織 / アディポサイトカイン / 脂肪細胞 / 動脈硬化 / 共培養 / 遺伝子欠損マウス

Outline of Final Research Achievements

We have reported that urolithiasis is a condition of Metabolic Syndrome (MetS). In this study, the following study was conducted to elucidate the relation between calculus formation stone formation stone matrix osteopontin (OPN) in MetS environment.
[1] Establishment of a co-culture system of adipocytes, macrophages and tubule cells, the attachment ability of calcium oxalate monohydrate crystals was most enhanced in the co-existence environment of three cells rather than tubule cells alone. [2] β3 agonist inducing beige cells with anti-MetS action was administered, and stone formation was significantly suppressed. [3] Urinary stones and arteriosclerosis were significantly suppressed by administering anti-OPN antibody to MetS model mice.

Research Products

• [Journal Article] Genome-wide gene expression profiling of Randall's plaques in calcium oxalate stone formers (2017)
  • Author(s): Taguchi K, Hamamoto S, Okada A, Unno R, Kamisawa H, Naiki T, Ando R, Mizuno K, Kawai N, Tozawa K, Kohri K, Yasui T
  • Journal Title: J Am Soc Nephrol Volume: 28 Issue: 1 Pages: 333-347
  • DOI: 10.1681/asn.2015111271
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Potassium-sodium citrate prevents the development of renal microcalculi into symptomatic stones in calcium stone-forming patients. (2017)
  • Author(s): Unno Rei, Taguchi Kazumi, Okada Atsushi, Ando Ryosuke, Hamamoto Shuzo, Kubota Yasue, Zuo Li, Tozawa Keiichi, Kohri Kenjiro, Yasui Takahiro
  • Journal Title: International Journal of Urology Volume: 24 Issue: 1 Pages: 75-81
  • DOI: 10.1111/iju.13242
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Two-year-old girl with impacted ureteral stone successfully treated with a single session of combined percutaneous nephrostomy and ureteroscopy. (2017)
  • Author(s): Sugino Teruaki, Hamamoto Shuzo, Unno Rei, Moritoki Yoshinobu, Hamakawa Takashi, Naiki Taku, Ando Ryosuke, Okada Atsushi, Yasui Takahiro
  • Journal Title: International Journal of Urology Volume: 24 Issue: 4 Pages: 326-329
  • DOI: 10.1111/iju.13319
  • Peer Reviewed
• [Journal Article] Optimizing RNA Extraction of Renal Papilla Biopsy Tissue in Kidney Stone Formers: A New Methodology for Genomic Study. (2017)
  • Author(s): Taguchi K, Usawachintachit M, Hamamoto S, Unno R, Tzou DT, Sherer BA, Wang Y, Okada A, Stoller ML, Yasui T, Chi T.
  • Journal Title: J Endourol Volume: 31 Issue: 9 Pages: 922-929
  • DOI: 10.1089/end.2017.0320
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] メタボリック症候群と泌尿器疾患 尿路結石とメタボリック症候群 (2017)
  • Author(s): 岡田 淳志、田口 和己、藤井 泰普、濵本 周造、安藤 亮介、安井 孝周
  • Journal Title: 泌尿器外科 Volume: 30 Pages: 133-141
• [Journal Article] 腎結石と5つの生活習慣病が慢性腎臓病の診断におよぼす影響 (2017)
  • Author(s): 安藤 亮介、永谷 照男、鈴木 貞夫、高橋 英勝、河合 信、海野 怜、濵本 周造、岡田 淳志、戸澤 啓一、安井 孝周
  • Journal Title: 日本腎泌尿器疾患予防医学研究会誌 Volume: 25 Pages: 56-57
  • Peer Reviewed
• [Journal Article] 特集 尿路結石に対する外科的治療―Stone free 100%を目指してESWL 治療成功のための工夫 (2017)
  • Author(s): 岡田 淳志
  • Journal Title: 臨床泌尿器科 Volume: 71 Pages: 670-676
• [Journal Article] 泌尿器科学 腎結石の原基Randall's plaqueの発生と関連遺伝子発現 (2017)
  • Author(s): 岡田 淳志、田口 和己、安井 孝周
  • Journal Title: 医学のあゆみ Volume: 263 Pages: 669-671
• [Journal Article] M1/M2-macrophage phenotypes regulate renal calcium oxalate crystal development (2017)
  • Author(s): 70.Taguchi Kazumi, Okada Atsushi, Hamamoto Shuzo, Unno Rei, Moritoki Yoshinobu, Ando Ryosuke, Mizuno Kentaro, Tozawa Keiichi, Kohri Kenjiro, Yasui Takaihro
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 35167-35167
  • DOI: 10.1038/srep35167
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Do teas rich in antioxidants reduce the physicochemical and peroxidative risk factors for calcium oxalate nephrolithiasis in humans? Pilot studies with Rooibos herbal tea and Japanese green tea. Urolithiasis. (2016)
  • Author(s): Rodgers A, Mokoena M, Durbach I, Lazarus J, de Jager S, Ackermann H, Breytenbach I, Okada A, Usami M, Hirose Y, Ando R, Yasui T, Kohri K
  • Journal Title: Urolithiasis Volume: Epub Issue: 4 Pages: 299-310
  • DOI: 10.1007/s00240-015-0855-4
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Proinflammatory and Metabolic Changes Facilitate Renal Crystal Deposition in an Obese Mouse Model of Metabolic Syndrome. (2015)
  • Author(s): Taguchi K, Okada A, Hamamoto S, Iwatsuki S, Naiki T, Ando R, Mizuno K, Tozawa K, Kohri K, Yasui T.
  • Journal Title: J Urol. Volume: 194 Issue: 6 Pages: 1787-96
  • DOI: 10.1016/j.juro.2015.07.083
  • Peer Reviewed / Open Access
• [Presentation] Osteopontin antibody in the suppression of kindney crystal formation in a mice model of metabolic syndrome. (2018)
  • Author(s): Sugino Teruaki, Taguchi Kazumi, Unno Rei, Tanaka Yutaro, Hamamoto Shuzo, Ando Ryosuke, Okada Atsushi, Mogami Tohru, Tozawa Keiichi, Kohri Kenjiro, Yasui Takahiro
  • Organizer: The 33rd Annual EAU Congress
  • Int'l Joint Research
• [Presentation] β3-adrenergic receptor agonist prevents kindney stone formation by suppressing inflammatory adipocytokine expression and improving antioxidant action (2018)
  • Author(s): Sugino Teruaki, Taguchi Kazumi, Tanaka Yutaro, Unno Rei, , Hamamoto Shuzo, Ando Ryosuke, Okada Atsushi, Mogami Tohru, Tozawa Keiichi, Kohri Kenjiro, Yasui Takahiro
  • Organizer: The 33rd Annual EAU Congress
  • Int'l Joint Research
• [Presentation] Discovery of a novel gene expression profile of renal papilla including Randall's plaque from calcium phosphate over calcium oxalate stone formers. (2018)
  • Author(s): Taguchi Kazumi, Hamamoto Shuzo, Tanaka Yutaro, Sugino Teruaki, Unno Rei, Ando Ryosuke, Okada Atsushi, Kohri Kenjiro, Yasui Takahiro
  • Organizer: The 33rd Annual EAU Congress
  • Int'l Joint Research
• [Presentation] 両側腎石灰化を生じたHDR症候群の1例 (2018)
  • Author(s): 田中 勇太朗、岡田 淳志、海野 怜、加藤 大貴、濱川 隆、濵本 周造、安藤 亮介、水野 健太郎、丸山 哲史、河合 憲康、戸澤 啓一、安井 孝周
  • Organizer: 第277回日本泌尿器科学会東海地方会
• [Presentation] rolithasis Pannel Discussion: Case management for urinary stones. (2017)
  • Author(s): Okada Atsushi
  • Organizer: Advancements in Urology 2017
  • Int'l Joint Research / Invited
• [Presentation] Bisphosphonates as a Countermeasure to Space Flight Induced Bone Loss (2017)
  • Author(s): LeBlanc Adrian, Matsumoto Toshio, Spector E, Jones J, Shapiro J, Lang T, Shackelford L, Smith M S, Evans H, Ploutz-Snyder R, Sibonga J, Keyak J, Nakamura Toshitaka, Kohri Kenjiro, Ohshima Hiroshi, Okada Atsushi, Yasui Takahiro
  • Organizer: 2017 NASA Human Research Program Investigators’ Workshop
  • Int'l Joint Research / Invited
• [Presentation] Stone Cases. (2017)
  • Author(s): Okada Atsushi
  • Organizer: 第105回日本泌尿器科学会総会
  • Invited
• [Presentation] Identification of novel urinary risk markers of urolithiasis by using logistic and multi-nominal logit models (2017)
  • Author(s): Okada Atsushi, Sugino Teruaki, Unno Rei, Taguchi Kazumi, Hamakawa Takashi, Hamamoto Shuzo, Ando Ryosuke, Kubota Yasue, Honma Hideki, Tozawa Keiichi, Kohri Kenjiro, Yasui Takahiro
  • Organizer: 第105回日本泌尿器科学会総会
• [Presentation] Autophagy's protective roles for kidney stone formation. (2017)
  • Author(s): Unno Rei, Sugino Teruaki, Taguchi Kazumi, Hamamoto Shuzo, Ando Ryosuke, Endo Sumio, Okada Atsushi, Sakakura Takeshi, Tozawa Keiichi, Kohri Kenjiro, Yasui Takahiro
  • Organizer: 第105回日本泌尿器科学会総会
• [Presentation] Successful results of endoscopic combined intrarenal surgery against large calculi; simultaneous use of flexible-ureteroscopy and mini-percutaneous nephrolithotomy. (2017)
  • Author(s): Hamamoto Shuzo, Sugino Teruaki, Unno Rei, Taguchi Kazumi, Fujii Yasuhiro, Ando Ryosuke, Okada Atsushi, Tozawa Keiichi, Yasui Takahiro
  • Organizer: 第105回日本泌尿器科学会総会
• [Presentation] Autophagy maintains cellular homeostasis and inhibits renal crystal formation. (2017)
  • Author(s): Unno Rei, Unno Naoko, Ota Yuya, Sugino Teruaki, Taguchi Kazumi, Hamamoto Shuzo, Ando Ryosuke, Okada Atsushi, Tozawa Keiichi, Kohri Kenjiro, Yasui Takahiro
  • Organizer: American Urological Association Annual Meeting 2017
  • Int'l Joint Research
• [Presentation] Nnt gene suppresses oxidative stress and kidney crystal deposition. (2017)
  • Author(s): Usami Masayuki, Ota Yuya, Sugino Teruaki, Unno Rei, Taguchi Kazumi, Hamamoto Shuzo, Ando Ryosuke, Okada Atsushi, Honma Hideki, Tozawa Keiichi, Kohri Kenjiro, Yasui Takahiro
  • Organizer: American Urological Association Annual Meeting 2017
  • Int'l Joint Research
• [Presentation] Identification of new urinary risk markers for urinary stone patients using logistic model and multinomial-logit model. (2017)
  • Author(s): Okada Atsushi, Sugino Teruaki, Unno Rei, Taguchi Kazumi, Hamamoto Shuzo, Ando Ryosuke, Tozawa Keiichi, Kohri Kenjiro, Yasui Takahiro
  • Organizer: American Urological Association Annual Meeting 2017
  • Int'l Joint Research
• [Presentation] Determinants of health-related quality of life after surgery: ureteroscopic versus shock wave lithotripsy. (2017)
  • Author(s): Hamamoto Shuzo, Sugino Teruaki, Unno Rei, Taguchi Kazumi, Ando Ryosuke, Okada Shinsuke, Inoue Takaaki, Okada Atsushi, Tozawa Keiichi, Yasui Takahiro
  • Organizer: American Urological Association Annual Meeting 2017
  • Int'l Joint Research
• [Presentation] A new navigation system of renal puncture for endoscopic combined intrarenal surgery: real-time virtual sonography-guided renal access. (2017)
  • Author(s): Hamamoto Shuzo, Sugino Teruaki , Unno Rei, Taguchi Kazumi, Ando Ryosuke, Okada Shinsuke, Inoue Takaaki, Okada Atsushi, Tozawa Keiichi, Yasui Takahiro
  • Organizer: American Urological Association Annual Meeting 2017
  • Int'l Joint Research
• [Presentation] Identification of the recommended techniques, case selection, and invention to improve extracorporeal shock wave lithotripsy success rates. (2017)
  • Author(s): Okada Atsushi, Sugino Teruaki, Unno Rei, Taguchi Kazumi, Hamamoto Shuzo, Ando Ryosuke, Tozawa Keiichi, Yasui Takahiro
  • Organizer: American Urological Association Annual Meeting 2017
  • Int'l Joint Research
• [Presentation] Pro-inflammatory and immune-active responses lead to Randall's plaque formation on calcium phosphate stone. (2017)
  • Author(s): Taguchi Kazumi, Hamamoto Shuzo, Sugino Teruaki, Unno Rei, Fujii Yasuhiro, Ando Ryosuke, Okada Atsushi, Kamiya Hiroyuki, Kohri Kenjiro, Yasui Takahiro
  • Organizer: UAA2017
  • Int'l Joint Research
• [Presentation] Alendronate ameliorates the risk of urinary stone formation of astronauts on the International Space Station for 6 months. (2017)
  • Author(s): Okada Atsushi, Yasui Takahiro, Kohri Kenjiro, Matsumoto Toshio, LeBlanc Adrian, Sibonga Jean, Spector Elisabeth, Jones Jeff, Shapiro Jay, Lang Thomas, Shackelford Linda, Smith Scott, Evans Harlan, Keyak Joyce, Ohshima Hiroshi
  • Organizer: ASMBMR 2017 Annual Meeting
  • Int'l Joint Research / Invited
• [Presentation] 尿路結石溶解療法に向けたマクロファージ制御因子の解明 (2017)
  • Author(s): 岡田 淳志、田口 和己、杉野 輝明、海野 怜、濵本 周造、安藤 亮介、戸澤 啓一、郡 健二郎、安井 孝周
  • Organizer: 第105回日本泌尿器科学会総会
  • Invited
• [Presentation] 尿管所見から考える嵌頓結石に対する理想的な治療介入時期の検討 (2017)
  • Author(s): 濵本 周造、岡田 真介、井上 貴昭、杉野 輝明、海野 奈央子、海野 怜、山田 健司、安藤 亮介、岡田 淳志、三浦 浩康、松田 公志、安井 孝周
  • Organizer: 第105回日本泌尿器科学会総会
• [Presentation] ルイボス茶による抗酸化作用および尿路結石に与える影響 (2017)
  • Author(s): 宇佐美 雅之、海野 怜、田口 和己、廣瀬 泰彦、濵本 周造、安藤 亮介、岡田 淳志、伊藤 恭典、戸澤 啓一、郡 健二郎、安井 孝周
  • Organizer: 第105回日本泌尿器科学会総会
• [Presentation] 当院におけるECIRS(endoscopic combined intrarenal surgery)の治療成績の検討 (2017)
  • Author(s): 藤井 泰普、野崎 哲史、田口 和己、濵本 周造、岡田 淳志、梅本 幸裕、神谷 浩行、安井 孝周
  • Organizer: 第105回日本泌尿器科学会総会
• [Presentation] 褐色脂肪細胞活性をもつベージュ細胞の分化誘導による尿路結石形成の制御 (2017)
  • Author(s): 杉野 輝明、岡田 淳志、海野 怜、田口 和己、安藤 亮介、濵本 周造、戸澤 啓一、郡 健二郎、安井 孝周
  • Organizer: 第60回日本腎臓学会学術総会
• [Presentation] オートファジー亢進により腎結石形成は制御される (2017)
  • Author(s): 海野 怜、杉野 輝明、田口 和己、藤井 泰普、濵本 周造、安藤 亮介、岡田 淳志、戸澤 啓一、郡 健二郎、安井 孝周
  • Organizer: 第60回日本腎臓学会学術総会
• [Presentation] 腎結石形成過程におけるオートファジーの機能解析 (2017)
  • Author(s): 海野 怜、杉野 輝明、田口 和己、濵本 周造、安藤 亮介、岡田 淳志、戸澤 啓一、安井 孝周
  • Organizer: 第161回名古屋市立大学医学会例会
• [Presentation] 食品・栄養素から考える尿路結石の予防 (2017)
  • Author(s): 安藤 亮介、鈴木 貞夫、岡田 淳志、伊藤 恭典、戸澤 啓一、安井 孝周
  • Organizer: 第26回日本腎泌尿器疾患予防医学研究会
• [Presentation] 腎結石形成過程における選択的オートファジーの機能解析 (2017)
  • Author(s): 海野 怜、杉野 輝明、田口 和己、廣瀬 泰彦、伊藤 靖彦、濵本 周造、安藤 亮介、岡田 淳志、戸澤 啓一、郡 健二郎、安井 孝周
  • Organizer: 日本尿路結石症学会第27回学術集会
• [Presentation] ベージュ細胞の分化誘導による尿路結石の予防法開発 (2017)
  • Author(s): 杉野 輝明、海野 怜、藤井 泰普、田口 和己、濵本 周造、宇佐美 雅之、小林 隆宏、安藤 亮介、岡田 淳志、戸澤 啓一、郡 健二郎、安井 孝周
  • Organizer: 日本尿路結石症学会第27回学術集会
• [Presentation] カルシウム結石溶解へ挑戦 (2017)
  • Author(s): 田口 和己、濵本 周造、岡田 淳志、戸澤 啓一、安井 孝周
  • Organizer: 日本尿路結石症学会第27回学術集会
• [Presentation] 内視鏡所見から考える尿管結石に対する理想的な治療介入の確立 (2017)
  • Author(s): 濵本 周造、岡田 真介、井上 貴昭、海野 怜、田口 和己、安藤 亮介、岡田 淳志、三浦 浩康、松田 公志、安井 孝周
  • Organizer: 第31回日本泌尿器内視鏡学会総会
• [Presentation] 砕石治療時における内視鏡下腎盂粘膜生検の安全性の検証とRNA抽出方法の最適化 (2017)
  • Author(s): 田口 和己、杉野 輝明、海野 怜、藤井 泰普、濵本 周造、安藤 亮介、岡田 淳志、神谷 浩行、Chi Thomas、安井 孝周
  • Organizer: 第31回日本泌尿器内視鏡学会総会
• [Presentation] ロボット支援腎部分切除術の初期症例における温阻血時間に影響する因子の同定 (2017)
  • Author(s): 岡田 淳志、守時 良演、濱川 隆、内木 拓、濵本 周造、安藤 亮介、水野 健太郎、河合 憲康、戸澤 啓一、安井 孝周
  • Organizer: 第31回日本泌尿器内視鏡学会総会
• [Presentation] ESWLの成功率向上に寄与するトレーニング・患者因子・治療因子の同定 (2017)
  • Author(s): 岡田 淳志、杉野 輝明、海野 怜、田口 和己、濵本 周造、戸澤 啓一、郡 健二郎、安井 孝周
  • Organizer: 第31回日本泌尿器内視鏡学会総会
• [Presentation] 尿路結石形成機構の解明と溶解治療への挑戦 (2017)
  • Author(s): 田口 和己、濵本 周造、岡田 淳志、安井 孝周
  • Organizer: 第67回日本泌尿器科学会中部総会
  • Invited
• [Presentation] 砕石治療時における内視鏡下腎盂粘膜生検の最適化 (2017)
  • Author(s): 田口 和己、杉野 輝明、海野 怜、藤井 泰普、濵本 周造、Tzou David、岡田 淳志、神谷 浩行、Stoller Marshall、郡 健二郎、Chi Thomas、安井 孝周
  • Organizer: 第67回日本泌尿器科学会中部総会
• [Presentation] ESWLを科学する：砕石率100%を目指して (2017)
  • Author(s): 岡田 淳志
  • Organizer: 第67回日本泌尿器科学会中部総会
  • Invited
• [Presentation] 術前評価と内視鏡所見 (2017)
  • Author(s): 濵本 周造、岡田 真介、井上 貴昭、海野 怜、安藤 亮介、岡田 淳志、戸澤 啓一、三浦 浩康、安井 孝周、松田 公志
  • Organizer: 第67回日本泌尿器科学会中部総会
  • Invited
• [Presentation] Technical training of the SWL to achieve 100% of success rates. (2016)
  • Author(s): Okada Atsushi
  • Organizer: 13th Annual Meeting of the East Asian Society of Endourology
  • Place of Presentation: イベントラボ・グランフロント大阪（大阪府大阪市）
  • Year and Date: 2016-11-19
  • Int'l Joint Research
• [Presentation] SE上部尿路結石内視鏡治療標準化委員会シンポジウム PNLの標準術式 (2016)
  • Author(s): 岡田 淳志、柿木 寛明、眞﨑 拓朗、吉水 敦、山口 秋人
  • Organizer: 第30回日本泌尿器科内視鏡学会総会
  • Place of Presentation: イベントラボ・グランフロント大阪（大阪府大阪市）
  • Year and Date: 2016-11-17
  • Invited
• [Presentation] Macrophage-derived cytokines and chemokines may be new markers for calcium oxalate stone formation risk in humans. (2016)
  • Author(s): Okada Atsushi, Unno Rei, Taguchi Kazumi, Fujii Yasuhiro, Hamamoto Shuzo, Ando Ryosuke, Tozawa Keiichi, Kohri Kenjiro, Yasui Takahiro
  • Organizer: 13th International Symposium on Urolithiasis,
  • Place of Presentation: 幕張メッセ（千葉県千葉市）
  • Year and Date: 2016-07-19
  • Int'l Joint Research / Invited
• [Presentation] Efficacy of ESWL training using human body-typed stone-targeting phantoms. (2016)
  • Author(s): Okada Atsushi, Unno Rei, Taguchi Kazumi, Hamamoto Shuzo, Itoh Yasunori, Tozawa Keiichi, Zuo Li, Gao Bing, Kohri Kenjiro, Yasui Takahiro
  • Organizer: 13th International Symposium on Urolithiasis
  • Place of Presentation: 幕張メッセ（千葉県千葉市）
  • Year and Date: 2016-07-19
  • Int'l Joint Research
• [Presentation] 腎結石患者に特異的な尿中マクロファージ関連マーカーの同定 (2016)
  • Author(s): 岡田 淳志、海野 怜、田口 和己、藤井 泰普、濵本 周造、安藤 亮介、戸澤 啓一、郡 健二郎、安井 孝周
  • Organizer: 第59回日本腎臓学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-06-17
• [Presentation] Identification of urinary macrophage-related factors specific to patients with calcium oxalate stones using multiplex analysis. (2016)
  • Author(s): Okada Atsushi, Taguchi Kazumi, Fujii Yasuhiro, Hamamoto Shuzo, Hirose Masahito, Itoh Yasunori, Tozawa Keiichi, Sasaki Shoichi, Hayashi Yutaro, Kohri Kenjiro, Yasui Takah
  • Organizer: American Urological Association Annual Meeting 2016
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2016-05-06
  • Int'l Joint Research
• [Presentation] Printed three-dimensional elastic organ model to increase robot-assisted laparoscopic partial nephrectomy performance. (2016)
  • Author(s): Okada Atsushi, Tozawa Keiichi, Kobayashi Daichi, Mizuno Kentaro, Umemoto Yukihiro, Kawai Noriyasu, Sasaki Shoichi, Hayashi Yutaro, Kunimoto Katsushi, Kohri Kenjiro, Yasui Takahiro
  • Organizer: American Urological Association Annual Meeting 2016
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2016-05-06
  • Int'l Joint Research
• [Presentation] Identification of the urinary macrophage-and neutrophil-related factors as new risk indexes for patients with urinary stones (2016)
  • Author(s): Okada Atsushi, Unno Rei, Fujii Yasuhiro, Taguchi Kazumi, Hamamoto Shuzo, Hirose Masahito, Tozawa Keiichi, Kohri Kenjiro, Yasui Takahiro
  • Organizer: 第104回日本泌尿器科学会総会
  • Place of Presentation: 仙台国際センター 他（宮城県仙台市）
  • Year and Date: 2016-04-23
• [Presentation] ファントムを使用したESWLトレーニングと、砕石率100%を目指した最新テクニック。 (2016)
  • Author(s): 岡田 淳志
  • Organizer: 第104回日本泌尿器科学会総会
  • Place of Presentation: 仙台国際センター 他（宮城県仙台市）
  • Year and Date: 2016-04-23
  • Invited
• [Presentation] 尿路結石症手術の教育 尿路結石症手術の教育：ESWL。 (2016)
  • Author(s): 岡田 淳志、海野 怜、濵本 周造、安藤 亮介、戸澤 啓一、安井 孝周
  • Organizer: 第30回日本泌尿器科内視鏡学会総会
  • Place of Presentation: イベントラボ・グランフロント大阪（大阪府大阪市）
  • Invited
• [Presentation] Hypercalciuria and migration of inflammatory macrophages play key roles for kidney stone formation in metabolic syndrome. (2015)
  • Author(s): Taguchi Kazumi, Unno Rei, Fujii Yasuhiro, Hamamoto Shuzo, Ando Ryosuke, Okada Atsushi, Yasui Takahiro, Fujita Keiji, Tozawa Keiichi, Hayashi Yutaro, Kohri Kenjiro
  • Organizer: American Urological Association Annual Meeting 2015
  • Place of Presentation: ニューオーリンズ(アメリカ)
  • Year and Date: 2015-05-15
  • Int'l Joint Research
• [Presentation] シュウ酸カルシウム結石患者に特異的な新規尿中因子IL-4の同定 (2015)
  • Author(s): 岡田淳志、安井 孝周、田口 和己、海野 怜、藤井 泰普、濵本 周造、広瀬 真仁、戸澤 啓一、郡 健二郎
  • Organizer: 第103回日本泌尿器科学会総会
  • Place of Presentation: 石川県立音楽堂、ANAクラウンプラザホテル金沢他(石川県金沢市)
  • Year and Date: 2015-04-18