| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Outline of Final Research Achievements |
The involvement of lysophosphatidic acid (LPA) signaling pathway in the regulation of trophoblast cell activities and placental function was investigated. We found that the serum level of autotaxin (ATX), a secretory enzyme essential for LPA production was remarkably elevated in pregnant women and that the placenta was a major source of ATX. In-vitro study revealed that LPA signaling induced the expression of the genes related to angiogenesis, immune modulation and cell differentiation in trophoblast cells. Abnormal expression pattern of the molecules associated with LPA signaling was observed in the placentas complicated with preeclampsia and fetal growth restriction, suggesting the relevance of deranged LPA signaling to pathoetiology of those diseases. Our findings propose that LPA signaling pathway can be a therapeutic target for preeclampsia and recurrent pregnancy loss.
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