Development of novel diagnosis and therapeutic procedures for nasal NK/T-cell lymphoma consists of targeting EBV-associated molecules
| Project/Area Number |
15H04986
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高原 幹 旭川医科大学, 医学部, 講師 (50322904)
長門 利純 旭川医科大学, 医学部, 助教 (80431419)
岸部 幹 旭川医科大学, 医学部, 講師 (80447101)
小林 博也 旭川医科大学, 医学部, 教授 (90280867)
上田 征吾 旭川医科大学, 医学部, 助教 (90447102)
駒林 優樹 旭川医科大学, 医学部, 助教 (40548864)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2017: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 頭頸部外科学 / 頭頸部外科 / 悪性腫瘍 |
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| Outline of Final Research Achievements |
We generated murine xenograft models inoculated with an natural killer/T-cell lymphoma cell line and revealed that sPD-L1 could be a prognostic predictor for NNKTL and open up the pos- sibility of immunotherapy of this lymphoma using PD-1/ PD-L1 axis inhibitors.
We revealed that circulating EBV‐miRNAs, particularly miR‐BART2‐5p, may serve as potential diagnostic and prognostic biomarkers in patients with nasal natural killer/T-cell lymphoma.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Programmed death-ligand 1 and its soluble form are highly expressed in nasal natural killer/T-cell lymphoma: a potential rationale for immunotherapy2017
Author(s)
Toshihiro Nagato, Takayuki Ohkuri, Kenzo Ohara, Yui Hirata, Kan Kishibe, Yuki Komabayashi, Seigo Ueda, Miki Takahara, Takumi Kumai, Kei Ishibashi, Akemi Kosaka, Naoko Aoki, Kensuke Oikawa, Yuji Uno, Naoko Akiyama, Masatoshi Sado, Hidehiro Takei, Esteban Celis, Yasuaki Harabuchi, Hiroya Kobayashi
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Journal Title
Cancer Immunol Immunother
Volume: 印刷中
Issue: 7
Pages: 877-890
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] CCL17 and CCL22/CCR4 signaling is a strong candidate for novel targeted therapy against nasal natural killer/T-cell lymphoma2015
Author(s)
Takumi Kumai, Toshihiro Nagato, Hiroya Kobayashi, Yuki Komabayashi, Seigo Ueda, Kan Kishibe, Takayuki Ohkuri, Miki Takahara, Esteban Celis, Yasuaki Harabuchi
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Journal Title
Cancer Immunology, Immunotherapy
Volume: -
Issue: 6
Pages: 697-705
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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