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Development of predicting factor for the efficacy of sublingual immunotherapy for Japanese cedar pollinosis using saliva

Research Project

Project/Area Number 15H04987
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionOkayama University

Principal Investigator

Okano Mitsuhiro  岡山大学, 医学部, 客員研究員 (60304359)

Co-Investigator(Kenkyū-buntansha) 檜垣 貴哉  岡山大学, 大学病院, 助教 (30587407)
春名 威範  岡山大学, 大学病院, 医員 (70646182)
野山 和廉  岡山大学, 大学病院, 医員 (80646183)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords舌下免疫療法 / 唾液 / IL-10 / アレルギー性鼻炎 / 効果予測 / マイクロバイオーム / 単球 / 症状薬物スコア / VAS / 予測 / プロテオーム / スギ花粉症 / コホート研究 / 微生物
Outline of Final Research Achievements

Although sublingual immunotherapy (SLIT) is a curative treatment for allergic rhinitis, this treatment needs long period to archive clinical remission. In addition, some patients are resistant to the treatment. We sought to determine whether saliva is associated with the clinical effectiveness of SLIT in Japanese cedar pollinosis.Both monocytes and THP-1 cells produced substantial amounts of IL-10 in response to whole saliva. Levels of IL-10 produced by THP-1 cells in response to saliva collected prior to SLIT were significantly higher in asymptomatic patients than disease-onset patients following SLIT. Our results provide a basis for why the sublingual route is effective and preferable in allergen immunotherapy. Saliva-induced IL-10 levels produced by THP-1 cells may be a predictive marker for clinical remission after SLIT.

Academic Significance and Societal Importance of the Research Achievements

研究成果の学術的な意義として、①舌下免疫療法の作用メカニズムの一端が解明されたこと、②舌下免疫療法の新しい治療効果予測法が開発されたことが挙げられる。舌下免疫療法の治療抗原が最初に反応する宿主の因子が唾液にも関わらず、これまで唾液に注目した研究はみられなかった。唾液が舌下免疫療法の効果に関わるという今回の研究成果は、国内外を通じて独創性が高い知見と考える。社会的意義としては、本研究によって舌下免疫療法が著効する患者選択を治療前に予測できる意義が挙げられる。舌下免疫療法は長期間の治療を要することから、より有効な患者に医療資源を投入することは医療経済的な意義も高いものと考える。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Annual Research Report
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (22 results)

All 2019 2018 2017 2016 2015

All Journal Article (8 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Open Access: 8 results,  Acknowledgement Compliant: 3 results) Presentation (11 results) (of which Int'l Joint Research: 7 results,  Invited: 5 results) Book (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Role of whole saliva in the efficacy of sublingual immunotherapy in seasonal allergic rhinitis2019

    • Author(s)
      Haruna T, Kariya S, Fujiwara T, Yuta A, Higaki T, Zhao P, Ogawa Y, Kanai K, Hitara Y, Oka A, Nishizaki K, Okano M.
    • Journal Title

      Allergology International

      Volume: 68 Issue: 1 Pages: 82-89

    • DOI

      10.1016/j.alit.2018.07.008

    • NAID

      130007557867

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] House dust mite sublingual tablet is effective and safe in patients with allergic rhinitis.2017

    • Author(s)
      Okamoto Y, Fujieda S, Okano M, Yoshida Y, Kakudo S, Masuyama K.
    • Journal Title

      Allergy

      Volume: 72 Issue: 3 Pages: 435-443

    • DOI

      10.1111/all.12996

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complementary and alternative medicine for allergic rhinitis in Japan2017

    • Author(s)
      Yonekura S, Okamoto Y, Sakurai D, Sakurai T, Iinuma T, Yamamoto H, Hanazawa T, Horiguchi S, Kurono Y, Honda K, Majima Y, Masuyama K, Takeda N, Fujieda S, Okano M, Ogino S, Okubo.
    • Journal Title

      Allergology International

      Volume: 66 Issue: 3 Pages: 425-431

    • DOI

      10.1016/j.alit.2016.10.006

    • NAID

      130005858792

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification and gene cloning of a new major allergen Cha o 3 from Chamaecyparis obtuse (Japanese cypress) pollen.2016

    • Author(s)
      Osada T, Harada T, Asaka N, Haruma T, Kino K, Sasaki E, Okano M, Yamada A, Utsugi T.
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 138 Issue: 3 Pages: 911-913

    • DOI

      10.1016/j.jaci.2016.03.026

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of intranasal corticosteroid on pre-onset activation of eosinophils and mast cells in experimental Japanese cedar pollinosis2016

    • Author(s)
      Noyama Y, Okano M, Fujiwara T, Kariya S, Makihara S, Haruna T, Kanai K, Higaki T, Nishizaki K.
    • Journal Title

      Allergology International

      Volume: 65 Issue: 3 Pages: 259-265

    • DOI

      10.1016/j.alit.2015.12.007

    • NAID

      130005165879

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effect of prostaglandin D2 on VEGF release by nasal polyp fibroblasts.2016

    • Author(s)
      Kanai K, Okano M, Fujiwara T, Kariya S, Haruna T, Omichi R, Makihara S, Hirata Y, Nishizaki K.
    • Journal Title

      Allergology International

      Volume: 印刷中 Issue: 4 Pages: 414-419

    • DOI

      10.1016/j.alit.2016.03.003

    • NAID

      130005431326

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Regulatory effect of TLR3 signaling on staphylococcal enterotoxin-induced IL-5, IL-13, IL-17A and IFN-γ production in chronic rhinosinusitis with nasal polyps2016

    • Author(s)
      Okano M, Fujiwara T, Kariya S, Higaki T, Makihara S, Haruna T, Noyama Y, Koyama T, Omichi R, Orita Y, Miki K, Kanai K, Nishizaki K.
    • Journal Title

      Allergology International

      Volume: 65 Issue: 1 Pages: 96-102

    • DOI

      10.1016/j.alit.2015.08.005

    • NAID

      130005290330

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Staphylococcal protein A-formulated immune complexes suppress enterotoxin-induced cellular responses in nasal polyps.2015

    • Author(s)
      Okano M, Fujiwara T, Kariya S, Haruna T, Higaki T, Noyama Y, Makihara SI, Kanai K, Nishizaki K.
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: ━ Issue: 2 Pages: 343-350

    • DOI

      10.1016/j.jaci.2014.10.058

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 制御性細胞の機能解析2019

    • Author(s)
      岡野光博
    • Organizer
      日本耳鼻咽喉科学会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] Usefulness of Saliva to Predict Clinical Remission after Sublingual Immunotherapy in Seasonal Allergic Rhinitis2018

    • Author(s)
      Mituhiro Okano
    • Organizer
      European Rhinologic Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Usefulness of Saliva to Predict Clinical Remission after Sublingual Immunotherapy in Allergic Rhinitis2018

    • Author(s)
      Mituhiro Okano
    • Organizer
      Korean Rhinologic Society
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Usefulness of saliva to predict clinical remission after2018

    • Author(s)
      岡野光博
    • Organizer
      American Academy of Asthma Allergy and Immunology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of saliva in the prediction of clinical remission after2018

    • Author(s)
      岡野光博
    • Organizer
      Korean Rhinologic Society
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 唾液を用いた舌下免疫療法の効果予測法開発の試み2017

    • Author(s)
      岡野光博
    • Organizer
      日本耳鼻咽喉科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 唾液によるヒト末梢血単球からのIL-10産生誘導作用2016

    • Author(s)
      岡野光博,仮谷伸,檜垣貴哉,春名威範,金井健吾,野山和廉,小山貴久,牧原靖一郎,西﨑和則
    • Organizer
      日本耳鼻咽喉科学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] Staphylococcal protein A-formulated immune complexes suppress enterotoxin-induced cellular responses in nasal polyps2015

    • Author(s)
      Mitsuhiro Okano
    • Organizer
      International Symposium on Recent Advances in Rhinosinusitis and Nasal Polyposis
    • Place of Presentation
      パナマシティ(パナマ)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] スギ花粉症に対する鼻噴霧用ステロイド薬初期療法の医療経済学的評価2015

    • Author(s)
      岡野光博、檜垣貴哉、春名威範、假谷 伸、野山和廉、小山貴久、藤原瑠美、趙 鵬飛、牧原靖一郎、金井健吾、西﨑和則
    • Organizer
      日本耳鼻咽喉科免疫アレルギー学会
    • Place of Presentation
      鳥羽市(三重県)
    • Year and Date
      2015-10-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Chronic rhinosinusitis and lung function2015

    • Author(s)
      Mitsuhiro Okano
    • Organizer
      World Congress of Rhinology
    • Place of Presentation
      サンパウロ(ブラジル)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Crosstalk of Staphylococcus aureus-derived components and COX metabolism in the pathogenesis of CRS2015

    • Author(s)
      Mitsuhiro Okano, Takenori Haruna and Kengo Kanai
    • Organizer
      Asian Research Symposium in Rhinology
    • Place of Presentation
      北京(中国)
    • Year and Date
      2015-04-10
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 今日の治療指針2016

    • Author(s)
      岡野光博
    • Total Pages
      2096
    • Publisher
      中山書店
    • Related Report
      2015 Annual Research Report
  • [Book] EBM 耳鼻咽喉科・頭頸部外科の治療 2015-20162015

    • Author(s)
      岡野光博、金井健吾
    • Total Pages
      687
    • Publisher
      中外医学社
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 口腔細菌叢の簡易予測法2017

    • Inventor(s)
      岡野光博、湯田厚司
    • Industrial Property Rights Holder
      岡野光博、湯田厚司
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017
    • Acquisition Date
      2018
    • Related Report
      2018 Annual Research Report

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Published: 2015-04-16   Modified: 2021-01-27  

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