Pre-clinical proof of concept trials for auditory hair cell regeneration by using hiPSC technology and marmoset model
| Project/Area Number |
15H04991
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Keio University |
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Principal Investigator |
Fujioka Masato 慶應義塾大学, 医学部(信濃町), 講師 (70398626)
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| Co-Investigator(Kenkyū-buntansha) |
小川 郁 慶應義塾大学, 医学部, 教授 (00169179)
岡野 ジェイムス洋尚 東京慈恵会医科大学, 医学部, 教授 (90338020)
水足 邦雄 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究施設、病院並びに防衛, 病院 耳鼻咽喉科科, 講師 (40338140)
原田 竜彦 国際医療福祉大学, 大学病院, 教授 (60238186)
細谷 誠 慶應義塾大学, 医学部(信濃町), 助教 (30645445)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | 内耳再生 / 耳科学 / 聴覚医学 / hiPS細胞 / 橋渡し研究 / 再生医療 / ヒトiPS細胞 / iPS細胞スクリーニング / マーモセット / 霊長類モデル / 橋渡し研究加速 / トランスレーショナルリサーチ / iPS創薬スクリーニング / 疾患特異的iPS |
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| Outline of Final Research Achievements |
We previously reported auditory hair cell regeneration with a hearing improvement in mouse (Neuron, 2013). Towards translation to the clinical trials, we selected better compounds by using otic progenitor cells derived from human iPS cells. We also examined the effect of above mentioned regenerative therapy in a non-human primate common marmoset.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Prevalence of TECTA mutation in patients with mid-frequency sensorineural hearing loss.2017
Author(s)
Yamamoto N, Mutai H, Namba K, Morita N, Masuda S, Nishi Y, Nakano A, Masuda S, Fujioka M, Kaga K, Ogawa K, Matsunaga T.
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Journal Title
Orphanet J Rare Dis
Volume: 25;12(1)
Issue: 1
Pages: 157-157
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Sustained Effect of Hyaluronic Acid in Subcutaneous Administration to the Cochlear Spiral Ganglion.2016
Author(s)
Inagaki Y, Fujioka M, Kanzaki S, Watanabe K, Oishi N, Itakura G, Yasuda A, Shibata S, Nakamura M, Okano HJ, Okano H, Ogawa K.
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Journal Title
PLoS One in press
Volume: 11
Issue: 4
Pages: e0153957-e0153957
DOI
Related Report
Peer Reviewed / Open Access
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