Comprehensive pathological analysis of detached retina and development of new treatment for the cell protection
Project/Area Number |
15H04994
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Nagoya University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
伊藤 逸毅 名古屋大学, 医学系研究科, 准教授 (10313991)
兼子 裕規 名古屋大学, 医学部附属病院, 病院講師 (20647458)
上野 真治 名古屋大学, 医学部附属病院, 講師 (80528670)
岩瀬 剛 名古屋大学, 医学部附属病院, 講師 (80642339)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
|
Keywords | 網膜剥離 / 網膜電図 / 光干渉断層計 / 補償光学 / 眼循環 / インターロイキン1β / microRNA / カベオリン1 / 剥離網膜 / インターロイキン1β / カペリオン1 / 細胞保護治療 |
Outline of Final Research Achievements |
We examined the recovery of disorganized retinal structure and function using ERG, optical coherence tomography (OCT), adoptive optics (AO), and LSFG. Cone interdigitation zone and the increased area of the retinal outer layer were correlated significantly with ERG b-wave amplitude improvement. Observation using the AO fundus camera showed the increased cone cell density after the scleral buckle surgery but it was less than that of the fellow eye. In the case of vitreous surgery for the retinal detachment, the retinal blood flow on the optic disc decreased before surgery but recovered after surgery. New prototype fiber-optic OCT was developed and clinically used for the patients. Biological analysis detected increased IL-1beta in the subretinal fluid in retinal detachment and specific expression of miR148a in the vitreous of eyes with retinal detachment. Higher expression of caveolin-1 in the fibrotic membrane in PVR had a role for preventing PVR pathogenesis.
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Report
(4 results)
Research Products
(216 results)
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[Journal Article] Efficacy and safety outcomes of intravitral aflibercept focusing on patients with diabetic macular edema from Japan.2018
Author(s)
Terasaki H, Shiraki K, Ohji M, Metzig C, Schmelter T, Zeitz O, Sowade O,Kobayashi M, Vitti R, Berliner A, Shiraga F
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Journal Title
Retina.
Volume: 0
Issue: 5
Pages: 0-0
DOI
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[Journal Article] Better Visual Outcome by Intraocular Lens Ejection in Geriatric Patients with Ruptured Ocular Injuries.2017
Author(s)
Kaneko H, Asami T, Sugita T, Tsunekawa T, Matsuura T, Takayama K, Yamamoto K, Kachi S, Ito Y, Ueno S, Nonobe N, Kataoka K, Suzumura A, Iwase T, Terasaki H.
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Journal Title
PLoS One
Volume: 12
Issue: 1
Pages: e0170094-e0170094
DOI
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Peer Reviewed / Open Access
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[Journal Article] Role of Caveolin-1 for Blocking the Epithelial-Mesenchymal Transition in Proliferative Vitreoretinopathy.2017
Author(s)
Nagasaka Y, Kaneko H, Ye F, Kachi S, Asami T, Kato S, Takayama K, Hwang SJ, Kataoka K, Shimizu H, Iwase T, Funahashi Y, Higuchi A, Senga T, Terasaki H.
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Journal Title
Invest Ophthalmol Vis Sci.
Volume: 58
Issue: 1
Pages: 221-229
DOI
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Peer Reviewed / Open Access
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[Journal Article] Nutritional supplementation inhibits the increase in serum malondialdehyde in patients with wet age-related macular degeneration.2017
Author(s)
Matsuura T, Takayama K, Kaneko H, Ye F, Fukukita H, Tsunekawa T, Kataoka K, Hwang SJ, Nagasaka Y, Ito Y, Terasaki H.
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Journal Title
Oxid Med Cell Longev.
Volume: 0
Issue: 1
Pages: 9548767-9548767
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Peer Reviewed / Open Access
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[Journal Article] Correlation between miR-148 Expression in Vitreous and Severity of Rhegmatogenous Retinal Detachment.2017
Author(s)
Tsunekawa T, Kaneko H, Takayama K, Hwang SJ, Oishi A, Nagasaka Y, Ye F, Iwase T, Nonobe N, Ueno S, Ito Y, Yasuda S, Matsuura T, Shimizu H, Suzumura A, Kataoka K, Terasaki H.
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Journal Title
Biomed Res Int.
Volume: 2017
Pages: 3427319-3427319
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Peer Reviewed / Open Access
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[Journal Article] Bilateral lacrimal caruncle lesions2017
Author(s)
Okumura Y, Takai Y, Yasuda S, Terasaki H. Bilateral lacrimal caruncle lesions.
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Journal Title
Nagoya Journal of Medical Science
Volume: 79
Issue: 1
Pages: 85-90
DOI
NAID
ISSN
2186-3326
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Peer Reviewed / Open Access
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[Journal Article] Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa2017
Author(s)
Sayo A, Ueno S, Kominami T, Nishida K, Inooka D, Nakanishi A, Yasuda S, Okado S, Takahashi K, Matsui S, Terasaki H.
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Journal Title
Sci Rep.
Volume: 7
Pages: 16383-16383
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Peer Reviewed / Open Access
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[Journal Article] 網膜機能障害解析の多角的アプローチ 網膜剥離を中心に2017
Author(s)
寺崎 浩子, 伊藤 逸毅, 岩瀬 剛, 兼子 裕規, 片岡 恵子, 杉田 糾, 丸子 留佳, 浅見 哲, 安田 俊介, 高山 圭, 大岩 和博, 川野 健一, 白井 博志, 羅 英明, 山本 健太郎, 中西 絢美, 小南 太郎, 古林 充里, 小南 梓, 長坂 洋介, 柳田 紘生, Vavvas Demetrios G., Miller Joan W.
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Journal Title
日本眼科学会雑誌
Volume: 121
Pages: 185-231
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[Journal Article] Long-term Protection of Genetically-Ablated Rabbit Retinal Degeneration by Sustained Transscleral Unoprostone Delivery2017
Author(s)
Nobuhiro Nagai, Eri Koyanagi, Yasuko Izumida, Junjun Liu, Aya Katsuyama, Hirokazu Kaji, Matsuhiko Nishizawa, Noriko Osumi, Mineo Kondo, Hiroko Terasaki, Yukihiko Mashima, Toru Nakazawa, Toshiaki Abe
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Journal Title
Investigative Ophthalmology & Visual Science
Volume: 57(15)
Issue: 15
Pages: 6527-6538
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Low-frequency coding variants in CETP and CFB are associated with susceptibility of exudative age-related macular degeneration in the Japanese population.2016
Author(s)
Momozawa Y, Akiyama M, Kamatani Y, Arakawa S, Yasuda M, Yoshida S, Oshima Y, Mori R, Tanaka K, Mori K, Inoue S, Terasaki H, Yasuma T, Honda S, Miki A, Inoue M, Fujisawa K, Takahashi K, Yasukawa T, Yanagi Y, Kadonosono K, Sonoda KH, Ishibashi T, Takahashi A, Kubo M.
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Journal Title
Hum Mol Genet.
Volume: 25
Pages: 5027-5034
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Peer Reviewed / Open Access
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[Journal Article] Nuclear factor (erythroid-derived)-related factor 2-associated retinal pigment epithelial cell protection under blue light-induced oxidative stress.2016
Author(s)
Takayama K, Kaneko H, Kataoka K, Kimoto R, Hwang SJ, Ye F, Nagasaka Y, Tsunekawa T, Matsuura T, Nonobe N, Ito Y, Terasaki H.
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Journal Title
Oxid Med Cell Longev.
Volume: 2016
Issue: 1
Pages: 8694641-8694641
DOI
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Peer Reviewed / Open Access
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[Journal Article] Intravitreal aflibercept for diabetic macular edema: 148-week results from the VISTA and VIVID Studies.2016
Author(s)
Heier JS, Korobelnik JF, Brown DM, Schmidt-Erfurth U, Do DV, Midena E, Boyer DS, Terasaki H, Kaiser PK, Marcus DM, Nguyen QD, Jaffe GJ, Slakter JS, Simader C, Soo Y, Schmelter T, Vitti R, Berliner AJ, Zeitz O, Metzig C, Holz FG.
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Journal Title
Ophthalmology.
Volume: 123
Issue: 11
Pages: 2376-2385
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Novel RP1L1 variants and genotype-photoreceptor microstructural phenotype associations in cohort of Japanese patients with occult macular dystrophy.2016
Author(s)
Fujinami K, Kameya S, Kikuchi S, Ueno S, Kondo M, Hayashi T, Shinoda K, Machida S, Kuniyoshi K, Kawamura Y, Akahori M, Yoshitake K, Katagiri S, Nakanishi A, Sakuramoto H, Ozawa Y, Tsubota K, Yamaki K, Mizota A, Terasaki H, Miyake Y, Iwata T, Tsunoda K.
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Journal Title
Invest Ophthalmol Vis Sci.
Volume: 57
Issue: 11
Pages: 4837-4846
DOI
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Increased ocular levels of microRNA-148a in cases of retinal detachment promote epithelial- mesenchymal transition.2016
Author(s)
Takayama K, Kaneko H, Hwang SJ, Ye F, Higuchi A, Tsunekawa T, Matsuura T, Iwase T, Asami T, Ito Y, Ueno S, Yasuda S, Nonobe N, Terasaki H.
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Journal Title
Invest Ophthalmol Vis Sci.
Volume: 57
Issue: 6
Pages: 2699-2705
DOI
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Peer Reviewed / Open Access
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[Journal Article] Clinical and genetic findings of autosomal recessive bestrophinopathy in Japanese cohort.2016
Author(s)
Nakanishi A, Ueno S, Hayashi T, Katagiri S, Kominami T, Ito Y, Gekka T, Masuda Y, Tsuneoka H, Shinoda K, Hirakata A, Inoue M, Fujinami K, Tsunoda K, Iwata T, Terasaki H.
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Journal Title
Am J Ophthalmol.
Volume: 168
Pages: 86-94
DOI
NAID
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Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Malondialdehyde induces autophagy dysfunction and VEGF secretion in the retinal pigment epithelium in age-related macular degeneration2016
Author(s)
Ye F, Kaneko H, Hayashi Y, Takayama K, Hwang SJ, Nishizawa Y, Kimoto R, Nagasaka Y, Tsunekawa T, Matsuura T, Yasukawa T, Kondo T, Terasaki H
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Journal Title
Free Radic Biol Med.
Volume: 94
Pages: 121-134
NAID
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Human IgG1 antibodies suppress angiogenesis in a target-independent manner2016
Author(s)
Bogdanovich S, Kim Y, Mizutani T, Yasuma R, Tudisco L, Cicatiello V, Bastos-Carvalho A, Kerur N, Hirano Y, Baffi JZ, Tarallo V, Li S, Yasuma T, Arpitha P, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ruvo M, et al.
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Journal Title
Signal Transduct Target Ther.
Volume: 1
Pages: 15001-15001
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[Journal Article] Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration.2016
Author(s)
Shirai H, Mandai M, Matsushita K, Kuwahara A, Yonemura S, Nakano T, Assawachananont J, Kimura T, Saito K, Terasaki H, Eiraku M, Sasai Y, Takahashi M.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 113
Issue: 1
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Peer Reviewed / Open Access
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[Journal Article] Influence of clinical factors and magnification correction on normal thickness profiles of macular retinal layers using optical coherence tomography2016
Author(s)
Higashide T, Ohkubo S, Hangai M, Ito Y, Shimada N, Ohno-Matsui K, Terasaki H, Sugiyama K, Chew P, Li KK, Yoshimura N
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Journal Title
NAID
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Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Intravitreal aflibercept for diabetic macular edema: 100-week results from the VISTA and VIVID studies2015
Author(s)
Brown DM, Schmidt-Erfurth U, Do DV, Holz FG, Boyer DS, Midena E, Heier JS, Terasaki H, Kaiser PK, Marcus DM, Nguyen QD, Jaffe GJ, Slakter JS, Simader C, Soo Y, Schmelter T, Yancopoulos GD, Stahl N, Vitti R, Berliner AJ, et al.
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Journal Title
Ophthalmology.
Volume: 122(10)
Issue: 10
Pages: 2044-2052
DOI
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[Journal Article] Multicenter observational study comparing sedation/analgesia protocols for laser photocoagulation treatment of retinopathy of prematurity.2015
Author(s)
Sato Y, Oshiro M, Takemoto K, Hosono H, Saito A, Kondo T, Aizu K, Matsusawa M, Futamura Y, Asami T, Terasaki H, Hayakawa M.
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Journal Title
J Perinatol.
Volume: 35
Issue: 11
Pages: 965-9
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[Journal Article] Macrophage- and RIP3-dependent inflammasome activation exacerbates retinal detachment-induced photoreceptor cell death2015
Author(s)
Kataoka K, Matsumoto H, Kaneko H, Notomi S, Takeuchi K, Sweigard JH, Atik A, Murakami Y, Connor KM, Terasaki H, Miller JW, Vavvas DG
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Journal Title
Cell Death Dis.
Volume: 6
Issue: 4
Pages: 1731-1731
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[Presentation] Transplantation of human induced pluripotent stem cell-derived retinal tissue in primate models of retinal degeneration with perimetric analysis2016
Author(s)
Shirai H, Mandai M, Kinoshita M, Onoe H, Matsushita K, Kuahara A, Yamasaki S, Terasaki H, Sasai Y, Takahashi M
Organizer
ARVO Annual Meeting 2016
Place of Presentation
USA,Seattle
Year and Date
2016-05-04
Related Report
Int'l Joint Research
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[Presentation] Increased ocular levels of microRNA-148a in cases of retinal detachment promote epithelial–mesenchymal transition2016
Author(s)
Takayama K, Kaneko H, Ye F, Hwang SJ, Iwase T, Asami T, Ito Y, Ueno S, Yasuda S, Terasaki H
Organizer
ARVO Annual Meeting 2016
Place of Presentation
USA,Seattle
Year and Date
2016-05-04
Related Report
Int'l Joint Research
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[Presentation] Protective effects of sustained unoprostone release device in Rhodopsin Pro347Leu transgenic rabbits2016
Author(s)
Nagai N, Izumida Y, Kaji H, Nishizawa M, Katsuyama A, Yamada S, Nakazawa T, Kondo M, Terasaki H, Mashima Y, Abe T
Organizer
ARVO Annual Meeting 2016
Place of Presentation
USA,Seattle
Year and Date
2016-05-03
Related Report
Int'l Joint Research
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[Presentation] Protective effects of sustained unoprostone release device in Rhodopsin Pro347Leu transgenic rabbits.2016
Author(s)
Nagai N, Izumida Y, Kaji H, Nishizawa M, Katsuyama A, Yamada S, Nakazawa T, Kondo M, Terasaki H, Mashima Y, Abe T.
Organizer
ARVO2016 Annual Meeting
Place of Presentation
Seattle(USA)
Related Report
Int'l Joint Research
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[Presentation] RPE dysfunction and cell deth2016
Author(s)
Shoji N, Murakami Y, Hisatomi T, Tachibana T, Ikeda Y, Terasaki H, Sonoda S, Blanz J, Sakamoto T, Aftig P, Ishibashi T, Miller J, Kroemer G, Campbell M
Organizer
XXII Biennial Meeting of International Society for Eye Research
Place of Presentation
京王プラザホテル(東京都・新宿区)
Related Report
Int'l Joint Research
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[Presentation] 術中OCT2015
Author(s)
寺崎浩子
Organizer
静岡OCT講習会
Place of Presentation
静岡県静岡市・ホテル アソシア静岡
Year and Date
2015-08-29
Related Report
Invited
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