Study of comprihensive vitreology
| Project/Area Number |
15H04996
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kagoshima University |
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Principal Investigator |
SAKAMOTO Taiji 鹿児島大学, 医歯学域医学系, 教授 (10235179)
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| Co-Investigator(Kenkyū-buntansha) |
丸山 征郎 鹿児島大学, 医歯学総合研究科, 特任教授 (20082282)
原 博満 鹿児島大学, 医歯学域医学系, 教授 (20392079)
橋口 照人 鹿児島大学, 医歯学域医学系, 教授 (70250917)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI Munekazu 鹿児島大学, 医歯学域医学系, 准教授 (20325814)
SONODA Shozo 鹿児島大学, 医歯学域附属病院, 講師 (20325806)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2017: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Keywords | 硝子体 / サイトカイン / 画像処理 / 機械学習 / 画像 / 網膜色素上皮 / 脈絡膜 / 画像診断 / 硝子体細胞 / 網膜疾患 / 光干渉断層計 / 網膜色素上皮細胞 / 網膜剥離 / ヒアロサイト / vitreous body / image analysis / vitrectomy / choroid |
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| Outline of Final Research Achievements |
We focused on the relationship of choroid disease and vitreous disease. By binarizing choroidal image with poor regularity, we succeeded in clarifying relationship between the structural change of choroid and pathological condition change, succeeded in more than 10 collaborative research domestically and overseas by this method, and commercialized. Although this method was a simple method of measuring the area of the processed image, it was a pioneering method and many results were obtained. In the research process, we succeeded in extracting features not noticed in ordinary images by analyzing images mathematically. Furthermore, by learning this feature amount by machine learning, a new structural pattern of the choroid could be obtained. The stratification of the choroid was realized by the Support Vector Machine created here. This means that quantification of choroids and automatic measurement become possible, and we have newly started joint research with domestic companies.
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Report
(4 results)
Research Products
(83 results)
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[Journal Article] Diurnal variations in luminal and stromal areas of choroid in normal eyes.2017
Author(s)
Kinoshita T, Mitamura Y Shinomiya K, Egawa M, Iwata A, Fujihara A, Ogushi Y, Semba K, Akaiwa K, Uchino E, Sonoda S, Sakamoto T
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Journal Title
Br J Ophthalmol
Volume: 101
Pages: 360-364
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Internal limiting membrane peeling-dependent retinal structural changes after vitrectomy in rhegmatogenous retinal detachment.2017
Author(s)
Hisatomi T, Tachibana T, Notomi S, Koyanagi Y, Murakami Y, Takeda A, Ikeda Y, Yoshida S, Enaida H, Murata T, Sakamoto T,Sonoda KH, Ishibashi T:
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Journal Title
Retina
Volume: 38（3）
Issue: 3
Pages: 471-479
DOI
Related Report
Peer Reviewed
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[Journal Article] Effects of exercise on the structure and circulation of choroid in normal eyes.2016
Author(s)
Kinoshita T, Mori J, Okuda N, Imaizumi H, Iwasaki M, Shimizu M, Miyamoto H, Akaiwa K, Semba K, Sonoda S, Sakamoto T, Mitamura Y
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Journal Title
PLoS ONE
Volume: 11(12)
Issue: 12
Pages: e0168336-e0168336
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Investigation of the association between IL10 gene polymorphisms and Vogt-Koyanagi-Harada disease in a Japanese population.2016
Author(s)
Kaori Higashia, Akira Meguroa, Masaki Takeuchiab, Takahiro Yamanea, Nobuyoshi Kitaichic, Yukihiro Horiec, Kenichi Nambad, Shigeaki Ohnod, Kumiko Nakaoe, Taiji Sakamotoe, at el.
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Journal Title
Ophthalmic Genetics
Volume: -
Issue: 2
Pages: 187-189
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] OCT angiographyの2値化と3機種における装置間誤差の検討2016
Author(s)
椎原秀樹, 園田祥三, 山下高明, 柿内奈保子, 黒岩宣宏, 内野英輔, 富田将利, 岩田一大, 迫口智紀, 土居範仁, 坂本泰二
Organizer
第70回日本臨床眼科学会
Place of Presentation
国立京都国際会館（京都府京都市）
Related Report
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