| Project/Area Number |
15H04999
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
HARADA Takayuki 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 分野長 (90345306)
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| Co-Investigator(Kenkyū-buntansha) |
岡原 純子 公益財団法人実験動物中央研究所, 応用発生学研究センター, 室長 (20464175)
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| Co-Investigator(Renkei-kenkyūsha) |
SASAKI Erika 公益財団法人実験動物中央研究所, マーモセット研究部 応用発生学研究センター, センター長 (70390739)
ISHIDA Susumu 北海道大学, 医学部, 教授 (10245558)
MITAMURA Yoshinori 徳島大学, 医学部, 教授 (30287536)
ICHIJO Hidenori 東京大学, 薬学部, 教授 (00242206)
TOKUNO Hironobu 公益財団法人東京都医学総合研究所, 認知症・高次脳機能システム研究分野, 副参事研究員 (40212071)
NAMEKATA Kazuhiko 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 副参事研究員 (70392355)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2017: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2016: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 緑内障 / 神経保護 / 視神経再生 / 疾患モデル動物 / マーモセット / 霊長類 / 軸索再生 / 疾患モデル |
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| Outline of Final Research Achievements |
The most common cause of blindness in Japan is glaucoma. Normal tension glaucoma (NTG) is a subtype of glaucoma that presents with statistically normal intraocular pressure (IOP), suggesting that non-IOP-dependent factors may contribute to the disease progression. Interestingly, 70% of glaucoma patients in Japan have NTG. In this project, we demonstrated that some existing drugs, nutrients that suppress oxidative stress and caloric restriction are effective for suppression of retinal degeneration in mouse models of glaucoma. In addition, we found that some aged marmosets, non-human primates, develop spontaneous NTG and we are preparing for generation of genetically modified NTG marmosets.
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