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Exploration of streptococcal factors related with onset of bacteremia and systemic dissemination

Research Project

Project/Area Number 15H05012
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionOsaka University

Principal Investigator

KAWABATA SHIGETADA  大阪大学, 歯学研究科, 教授 (50273694)

Co-Investigator(Kenkyū-buntansha) 山口 雅也  大阪大学, 歯学研究科, 助教 (00714536)
住友 倫子  大阪大学, 歯学研究科, 講師 (50423421)
中田 匡宣  大阪大学, 歯学研究科, 准教授 (90444497)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2017: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2016: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywordsレンサ球菌 / 菌血症 / 病原性レンサ球菌
Outline of Final Research Achievements

During the onset of invasive streptococcal diseases, bacteria systemically disseminate via the bloodstream. The exact mechanism by which pathogenic streptococci evade host immunity and disseminate to the bloodstream remains elusive. In this study, we revealed factors of pathogenic streptococci, including Streptococcus pneumoniae, Streptococcus pyogenes, and oral streptococci, involved in tissue invasion, immune evasion, and bacterial survival in the blood stream.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • Research Products

    (85 results)

All 2018 2017 2016 2015 Other

All Int'l Joint Research (1 results) Journal Article (27 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 25 results,  Open Access: 20 results,  Acknowledgement Compliant: 4 results) Presentation (44 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results) Book (11 results) Remarks (2 results)

  • [Int'l Joint Research] University of Madras/Kannur University(India)

    • Related Report
      2017 Annual Research Report
  • [Journal Article] Role of streptococcal polysaccharide capsules and glycosidases in the pathogenesis2018

    • Author(s)
      Yamaguchi Masaya、Nakata Masanobu、Sumioka Ryuichi、Hirose Yujiro、Wada Satoshi、Akeda Yukihiro、Sumitomo Tomoko、Kawabata Shigetada
    • Journal Title

      生化学

      Volume: 90 Issue: 1 Pages: 80-83

    • DOI

      10.14952/SEIKAGAKU.2018.900080

    • NAID

      40021494458

    • ISSN
      0037-1017
    • Year and Date
      2018-02-25
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Streptococcal Cysteine Protease-Mediated Cleavage of Desmogleins Is Involved in the Pathogenesis of Cutaneous Infection2018

    • Author(s)
      Sumitomo Tomoko、Mori Yasushi、Nakamura Yuumi、Honda-Ogawa Mariko、Nakagawa Seitaro、Yamaguchi Masaya、Matsue Hiroyuki、Terao Yutaka、Nakata Masanobu、Kawabata Shigetada
    • Journal Title

      Front Cell Infect Microbiol

      Volume: 8 Pages: 10-10

    • DOI

      10.3389/fcimb.2018.00010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of trophic factors secreted from human adipose-derived stromal vascular fraction with those from adipose-derived stromal/stem cells in the same individuals2018

    • Author(s)
      Hirose Y, Funahashi Y, Matsukawa Y, Majima T, Yamaguchi M, Kawabata S, Gotoh M, Yamamoto T
    • Journal Title

      Cytotherapy

      Volume: 20 Issue: 4 Pages: 589-591

    • DOI

      10.1016/j.jcyt.2018.02.001

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Oral Biofilms from Symbiotic to Pathogenic Interactions and Associated Disease ?Connection of Periodontitis and Rheumatic Arthritis by Peptidylarginine Deiminase2018

    • Author(s)
      Kriebel Katja、Hieke Cathleen、Muller-Hilke Brigitte、Nakata Masanobu、Kreikemeyer Bernd
    • Journal Title

      Front.Microbiol

      Volume: 9 Pages: 53-53

    • DOI

      10.3389/fmicb.2018.00053

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-like Receptors and Cytokines in Pneumococcal Pneumonia2018

    • Author(s)
      Domon Hisanori、Nagai Kosuke、Maekawa Tomoki、Oda Masataka、Yonezawa Daisuke、Takeda Wataru、Hiyoshi Takumi、Tamura Hikaru、Yamaguchi Masaya、Kawabata Shigetada、Terao Yutaka
    • Journal Title

      Front Immunol

      Volume: 印刷中 Pages: 732-732

    • DOI

      10.3389/fimmu.2018.00732

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synergistic findings from microbiological and evolutional analyses of virulence factors among pathogenic streptococcal species2018

    • Author(s)
      Yamaguchi Masaya
    • Journal Title

      J. Oral Biosci.

      Volume: in press Issue: 2 Pages: 36-40

    • DOI

      10.1016/j.job.2018.02.004

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pneumococcal DNA-binding proteins released through autolysis induce the production of proinflammatory cytokines via toll-like receptor 42018

    • Author(s)
      Nagai Kosuke、Domon Hisanori、Maekawa Tomoki、Oda Masataka、Hiyoshi Takumi、Tamura Hikaru、Yonezawa Daisuke、Arai Yoshiaki、Yokoji Mai、Tabeta Koichi、Habuka Rie、Saitoh Akihiko、Yamaguchi Masaya、Kawabata Shigetada、Terao Yutaka
    • Journal Title

      Cell Immunol

      Volume: 325 Pages: 14-22

    • DOI

      10.1016/j.cellimm.2018.01.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Streptococcus pyogenes CAMP factor promotes bacterial adhesion and invasion in pharyngeal epithelial cells without serum via PI3K/Akt signaling pathway2018

    • Author(s)
      Kurosawa Mie、Oda Masataka、Domon Hisanori、Isono Toshihito、Nakamura Yuki、Saitoh Issei、Hayasaki Haruaki、Yamaguchi Masaya、Kawabata Shigetada、Terao Yutaka
    • Journal Title

      Microbes Infect

      Volume: 20 Issue: 1 Pages: 9-18

    • DOI

      10.1016/j.micinf.2017.09.007

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Composition of salivary microbiota in elderly subjects2018

    • Author(s)
      Ogawa Taiji、Hirose Yujiro、Honda-Ogawa Mariko、Sugimoto Minami、Sasaki Satoshi、Kibi Masahito、Kawabata Shigetada、Ikebe Kazunori、Maeda Yoshinobu
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 414-414

    • DOI

      10.1038/s41598-017-18677-0

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Streptococcus pneumoniae surface protein PfbA is a versatile multidomain and multiligand-binding adhesin employing different binding mechanisms2017

    • Author(s)
      Beulin Darwin Selvi Jemima、Radhakrishnan Deepthi、Suresh Sharanya C.、Sadasivan Chittalakottu、Yamaguchi Masaya、Kawabata Shigetada、Ponnuraj Karthe
    • Journal Title

      FEBS J

      Volume: 284 Issue: 20 Pages: 3404-3421

    • DOI

      10.1111/febs.14200

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Streptococcus pyogenes Phospholipase A2 Induces the Expression of Adhesion Molecules on Human Umbilical Vein Endothelial Cells and Aorta of Mice2017

    • Author(s)
      Oda Masataka、Domon Hisanori、Kurosawa Mie、Isono Toshihito、Maekawa Tomoki、Yamaguchi Masaya、Kawabata Shigetada、Terao Yutaka
    • Journal Title

      Front Cell Infect Microbiol

      Volume: 7 Pages: 300-300

    • DOI

      10.3389/fcimb.2017.00300

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Zinc metalloproteinase ZmpC suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems2017

    • Author(s)
      Yamaguchi Masaya、Nakata Masanobu、Sumioka Ryuichi、Hirose Yujiro、Wada Satoshi、Akeda Yukihiro、Sumitomo Tomoko、Kawabata Shigetada
    • Journal Title

      Virulence

      Volume: 8 Issue: 8 Pages: 1516-1524

    • DOI

      10.1080/21505594.2017.1328333

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterizations of oral microbiota in elderly nursing home residents with diabetes2017

    • Author(s)
      Ogawa Taiji、Honda-Ogawa Mariko、Ikebe Kazunori、Notomi Yumiko、Iwamoto Yoshiko、Shirobayashi Itsuki、Hata Seiko、Kibi Masahito、Masayasu Shizuko、Sasaki Satoshi、Kawabata Shigetada、Maeda Yoshinobu
    • Journal Title

      Journal of Oral Science

      Volume: 59 Issue: 4 Pages: 549-555

    • DOI

      10.2334/josnusd.16-0722

    • NAID

      130006286386

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microbiological assessment of effects of clinical mouth rinses on common oral microbes2017

    • Author(s)
      Ogawa T, Ogawa-Honda M, Ikebe K, Kawabata S, Maeda Y
    • Journal Title

      Journal of Oral Science

      Volume: 59 Issue: 3 Pages: 391-395

    • DOI

      10.2334/josnusd.16-0417

    • NAID

      130006077658

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] treptococcus pyogenes Endopeptidase O Contributes to Evasion from Complement-mediated Bacteriolysis via Binding to Human Complement Factor C1q2017

    • Author(s)
      Honda-Ogawa M., Sumitomo T., Mori Y., Hamd DT, Ogawa T., Yamaguchi M., Nakata M., Kawabata S.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Issue: 10 Pages: 4244-4254

    • DOI

      10.1074/jbc.m116.749275

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Streptococcus sanguinis induces neutrophil cell death by production of hydrogen peroxide.2017

    • Author(s)
      Sumioka, R., Nakata, M., Okahashi, N., Li, Y., Wada, S., Yamaguchi, M., Sumitomo, T., Hayashi, M., Kawabata, S.
    • Journal Title

      PLoS One

      Volume: 12 Issue: 2 Pages: e0172223-e0172223

    • DOI

      10.1371/journal.pone.0172223

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Microbiological assessment of effects of clinical mouth rinses on common oral microbes.2017

    • Author(s)
      Ogawa, T., Ogawa-Honda, M., Ikebe, K., Kawabata, S., Maeda, Y.
    • Journal Title

      Journal of Oral Science

      Volume: -

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Degradation of bradykinin by a metalloendopeptidase from Streptococcus pyogenes.2016

    • Author(s)
      Miyamoto, T., Akaike, T., Kawabata, S., Akuta, T., Taruki, C., Yoshitake, J., Hamada, S., Ota, F., Ikarashi, H., Yoshimura, K., Kamijo, R., Maeda, H.
    • Journal Title

      Journal of Oral Biosciences

      Volume: 58 Issue: 4 Pages: 167-172

    • DOI

      10.1016/j.job.2016.07.003

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lysine and threonine biosynthesis from aspartate contributes to Staphylococcus aureus growth in calf serum.2016

    • Author(s)
      Oogai, Y., Yamaguchi, M., Kawada-Matsuo, M., Sumitomo, T., Kawabata, S., Komatsuzawa, H.
    • Journal Title

      Applied and Environmental Microbiology

      Volume: 82 Issue: 20 Pages: 6150-6157

    • DOI

      10.1128/aem.01399-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evolutionary inactivation of a sialidase ingroup B Streptococcus.2016

    • Author(s)
      Yamaguchi, M., Hirose, Y., Nakata, M., Uchiyama, S., Yamaguchi, Y., Goto, K., Sumitomo, T., Lewis, A., Kawabata, S., Nizet, V.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 28852-28852

    • DOI

      10.1038/srep28852

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Streptococcus oralis induces lysosomal impairment of macrophages via bacterial hydrogen peroxide.2016

    • Author(s)
      Okahashi, N., Nakata, M., Kuwata, H., Kawabata, S.
    • Journal Title

      Infection and Immunity

      Volume: 84 Issue: 7 Pages: 2042-2050

    • DOI

      10.1128/iai.00134-16

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of extracellular pH on Dental Pulp Cells in Vitro2016

    • Author(s)
      Hirose, Y., Yamaguchi, M., Kawabata, S., Murakami, M., Nakashima, M., Gotoh, M., Yamamoto, T.
    • Journal Title

      Journal of endodontics

      Volume: 印刷中 Issue: 5 Pages: 735-741

    • DOI

      10.1016/j.joen.2016.01.019

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Group A Streptococcus exploits human plasminogen for bacterial translocation across epithelial barrier via tricellular tight junctions.2016

    • Author(s)
      Sumitomo T, Nakata M, Higashino M, Yamaguchi M, Kawabata S.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 20069-20069

    • DOI

      10.1038/srep20069

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Injection of Dental Pulp Stem Cells Promotes Healing of Damaged Bladder Tissue in a Rat Model of Chemically Induced Cystitis.2015

    • Author(s)
      Hirose Y, Yamamoto T, Misako N, Funahashi Y, Matsukawa Y, Yamaguchi M, Kawabata S, Gotoh M.
    • Journal Title

      Cell Transplant

      Volume: 25 Issue: 3 Pages: 425-436

    • DOI

      10.3727/096368915x689523

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular and genomic characterization of pathogenic traits of group A <i>Streptococcus pyogenes</i>2015

    • Author(s)
      Hamada S, Kawabata S, Nakagawa I.
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 91 Issue: 10 Pages: 539-559

    • DOI

      10.2183/pjab.91.539

    • NAID

      130005129678

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] インフルエンザに関連する細菌性肺炎2015

    • Author(s)
      住友倫子,川端重忠
    • Journal Title

      日本歯科医師会雑誌

      Volume: 68 (7) Pages: 16-17

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 中田匡宣,川端重忠2015

    • Author(s)
      中田匡宣,川端重忠
    • Journal Title

      日本歯科医師会雑誌

      Volume: 68 (4) Pages: 16-17

    • Related Report
      2015 Annual Research Report
  • [Presentation] Streptococcus pyogenesが産生するArcAは皮膚病変形成に寄与する2018

    • Author(s)
      広瀬雄二郎,山口雅也,後藤花奈,住友倫子,中田匡宣,川端重忠
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肺炎球菌のコリン結合タンパク質CbpJおよびCbpLの肺炎発症における役割の解析2018

    • Author(s)
      後藤花奈,山口雅也,広瀬雄二郎,住友倫子,中田匡宣,川端重忠
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] インフルエンザウイルス感染は化膿レンサ球菌の上皮バリア突破を亢進させる2017

    • Author(s)
      住友倫子,中田匡宣,山口雅也,川端重忠
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肺炎球菌のメタロプロテアーゼZmpCは中枢系への菌の侵入を抑制する2017

    • Author(s)
      山口雅也,広瀬雄二郎,明田幸宏,住友倫子,川端重忠
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 化膿レンサ球菌のendopeptidaseOと補体C1qの相互作用が病原性に及ぼす影響2017

    • Author(s)
      本多真理子,住友倫子,山口雅也,中田匡宣,川端重忠
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肺炎球菌のCcs4は脳血管内皮細胞への侵入に寄与する病原因子である2017

    • Author(s)
      広瀬雄二郎,山口雅也,後藤花奈,住友倫子,中田匡宣,川端重忠
    • Organizer
      第90回日本細菌学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] Streptococcal cysteine protease-mediated cleavage of desmogleins contributes to development of cutaneous infection.2017

    • Author(s)
      Sumitomo T., Mori Y., Nakamura Y., Ogawa-Honda M., Yamaguchi M., Terao Y., Nakata M., Kawabata S.
    • Organizer
      IUMS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Streptococcus pneumoniae Ccs4 that is involved in invasion into brain across blood-brain barrier impacts its virulence in meningitis.2017

    • Author(s)
      Hirose Y., Yamaguchi M., Goto K., Sumitomo T., Nakata M., Kawabata S.
    • Organizer
      LISSSD2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Streptococcus pneumoniae evades host innate immunity through parallel beta-helix protein PfbA.2017

    • Author(s)
      Yamaguchi M., Hirose Y., Goto K., Sumitomo T., Nakata M., Kawabata S.
    • Organizer
      LISSSD2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 分子系統解析を利用したStreptococcus agalactiaeのシアル酸分解酵素の機能解析2017

    • Author(s)
      山口雅也
    • Organizer
      第59回歯科基礎医学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 肺炎球菌のbeta-ヘリックス構造タンパク質PfbAを介した貪食回避機構の解析2017

    • Author(s)
      山口雅也,広瀬雄二郎,後藤花奈,竹村 萌,住友倫子,中田匡宣,川端重忠
    • Organizer
      第91回日本細菌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Streptococcus pneumoniae Ccs4は脳血管内皮細胞への付着・侵入を促進する病原因子である2017

    • Author(s)
      広瀬雄二郎,山口雅也,後藤花奈,住友倫子,中田匡宣,川端重忠
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 肺炎球菌の CbpJ が肺炎発症に果たす役割の解析2017

    • Author(s)
      後藤花奈,山口雅也,広瀬雄二郎,住友倫子,中田匡宣,川端重忠
    • Organizer
      第70回日本細菌学会関西支部総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A型インフルエンザウイルス感染に伴い表在化するGP96は化膿レンサ球菌の上皮細胞への付着を亢進させる2017

    • Author(s)
      住友倫子,中田匡宣,山口雅也,川端重忠
    • Organizer
      第65回日本ウイルス学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] インフルエンザウイルス感染によるSnail1 の発現誘導は化膿レンサ球菌の上皮バリア突破を亢進させる2017

    • Author(s)
      住友倫子,中田匡宣,山口雅也,川端重忠
    • Organizer
      第59回歯科基礎医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Streptococcus pneumoniae のコリン結合タンパク質CbpJ は肺炎発症における病原因子として働く2017

    • Author(s)
      後藤花奈,山口雅也,広瀬雄二郎,住友倫子,中田匡宜,川端重忠
    • Organizer
      第59回歯科基礎医学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] M3型 化膿レンサ球菌が産生する線毛タンパク質 FctA3の結晶構造解析2016

    • Author(s)
      寒川 剛、武部 克希、中田 匡宣、川端 重忠、鈴木 守
    • Organizer
      日本結晶学会平成28年度年会
    • Place of Presentation
      茨城県立県民文化センター(茨城県水戸市)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肺炎球菌が発現する形質転換誘導性タンパク質Ccs4の病原性への関与2016

    • Author(s)
      広瀬雄二郎、山口雅也、後藤花奈、住友倫子、中田匡宣、川端重忠
    • Organizer
      第4回 口腔微生物研究会
    • Place of Presentation
      丸駒温泉旅館(北海道千歳市)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Annual Research Report
  • [Presentation] 環境温度の変化に対する肺炎球菌の適応と血中における菌体生存の関連2016

    • Author(s)
      中田匡宣、住友倫子、山口雅也、川端重忠
    • Organizer
      第58回 歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] インフルエンザウイルス感染に伴い上皮表層に誘導されるGP96は化膿レンサ球菌の上皮細胞への付着を亢進させる2016

    • Author(s)
      住友倫子、中田匡宣、毛利泰士、小川真理子、山口雅也、川端重忠
    • Organizer
      第58回 歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベ8ンションセンター(北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肺炎球菌の菌体表層タンパクPfbAは宿主の自然免疫機構からの回避に寄与する2016

    • Author(s)
      山口雅也、広瀬雄二郎、後藤花奈、住友倫子、中田匡宣、川端重忠
    • Organizer
      第58回 歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] C1qとの相互作用を介する化膿レンサ球菌の補体免疫回避機構2016

    • Author(s)
      小川真理子、住友倫子、毛利泰士、山口雅也、中田匡宣、川端重忠
    • Organizer
      第58回 歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] 形質転換誘導性タンパク質Ccs4がStreptococcus pneumoniae の病原性に与える影響2016

    • Author(s)
      広瀬雄二郎、山口雅也、後藤花奈、住友倫子、中田匡宣、川端重忠
    • Organizer
      第58回 歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Streptococcus oralis 由来の過酸化水素はマクロファージのリソソームを障害する2016

    • Author(s)
      岡橋暢夫、中田匡宣、桑田啓貴、川端重忠
    • Organizer
      第58回 歯科基礎医学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(北海道札幌市)
    • Year and Date
      2016-08-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] Streptococcus pyogenesが産生するendopeptidase OとC1qの結合による補体免疫回避機構2016

    • Author(s)
      本多真理子、住友倫子、毛利泰士、Dalia Hamd、山口雅也、中田匡宣、川端重忠
    • Organizer
      第48回 レンサ球菌研究会
    • Place of Presentation
      長崎大学(長崎県長崎市)
    • Year and Date
      2016-07-08
    • Related Report
      2016 Annual Research Report
  • [Presentation] Involvement of Group A streptococcal endopeptidase O in evasion from complement-mediated bacteriolysis via binding to complement C1q2016

    • Author(s)
      Honda M, Sumitomo T, Mori Y, Yamaguchi M, Nakata M, and Kawabata S
    • Organizer
      The 13th Korea-Japan International Symposium on Microbiology
    • Place of Presentation
      The-K Hotel Gyeongju, Gyeongju city, Korea
    • Year and Date
      2016-05-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] B群レンサ球菌におけるシアル酸分解酵素NonAの進化的な不活性化2016

    • Author(s)
      山口雅也、広瀬雄二郎、後藤花奈、住友倫子、川端重忠
    • Organizer
      第90回 日本感染症学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-04-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] 培養温度の変化が肺炎球菌の血中での生存に及ぼす影響2016

    • Author(s)
      中田匡宣,住友倫子,山口雅也,川端重忠
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] インフルエンザウイルス感染に伴うGp96の局在と化膿レンサ球菌感染症の関連性2016

    • Author(s)
      住友倫子,中田匡宣,山口雅也,川端重忠
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肺炎球菌の菌体表層タンパクPfbAによる自然免疫回避機構の解析2016

    • Author(s)
      山口雅也,広瀬雄二郎,住友倫子,中田匡宣,川端重忠
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Streptococcus pneumoniaeの形質転換誘導性タンパクCcs4は病原因子として働く2016

    • Author(s)
      広瀬雄二郎,山口雅也,後藤花奈,住友倫子,中田匡宣,川端重忠
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Stretptococcus sanguinis由来の過酸化水素は好中球にNETsを誘導する2016

    • Author(s)
      住岡龍一,中田国宣,和田聖史,岡橋暢夫,住友倫子,山口雅也,林美加子,川端重忠
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] Streptococcus pyogenes のシ ステインプロテアーゼによるデスモグレイン分解が皮膚感染 症の発症に及ぼす影響2016

    • Author(s)
      毛利泰士,住友倫子,本多真理子,山口雅也,寺尾豊,中田匡宣,川端重忠
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] A 群レンサ球菌の endopeptidase O による補 体 C1q を介した補体免疫回避機構2016

    • Author(s)
      本多 真理子,住友 倫子,毛利 泰士,山口 雅也,中田 匡宣,川端 重忠
    • Organizer
      第89回日本細菌学会総会
    • Place of Presentation
      大阪国際交流センター(大阪府大阪市)
    • Year and Date
      2016-03-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] 分子進化解析を利用したB群レンサ球菌のシアル酸分解酵素が病原性に果たす役割の解明2016

    • Author(s)
      山口雅也、広瀬雄二郎、中田匡宣、後藤花奈、住友倫子、川端重忠
    • Organizer
      第63回 日本生化学会近畿支部例会
    • Place of Presentation
      神戸薬科大学(兵庫県神戸市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Streptococcus pyogenesによる皮膚病変の形成機構に関する解析2016

    • Author(s)
      毛利泰士、住友倫子、松岡悠美、本多真理子、山口雅也、寺尾豊、中田匡宣、川端重忠
    • Organizer
      第69回 日本細菌学会関西支部総会
    • Place of Presentation
      大阪市立大学 杉本キャンパス 田中記念館(大阪府大阪市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] A群レンサ球菌が産生する分泌型プロテアーゼによるデスモグレイン分解と皮膚病態発症の関連2015

    • Author(s)
      毛利泰士,住友倫子,本多真理子,山口雅也,寺尾豊,中田匡宣,川端重忠
    • Organizer
      第68回日本細菌学会関西支部総会
    • Place of Presentation
      京都薬科大学(京都府京都市)
    • Year and Date
      2015-11-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Streptococcus agalactiaeのシアル酸分解酵素に着目した分子進化解析(Molecular evolutionary analysis on inactive sialidase of Streptococcus agalactiae)2015

    • Author(s)
      山口雅也,中田匡宣,広瀬雄二郎,後藤花奈,住友倫子,川端重忠
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)(新潟県新潟市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肺炎球菌による宿主細胞の細胞死誘導能の解析(Analysis of pneumococcus-induced cell death)2015

    • Author(s)
      土門久哲,坂上雄樹,小田真隆,山口雅也,川端重忠,寺尾豊
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)(新潟県新潟市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Streptococcus pyogenesに起因する皮膚感染症の発症におけるSpeBの関与2015

    • Author(s)
      毛利泰士,住友倫子,山口雅也,中田匡宣,寺尾豊,川端重忠
    • Organizer
      第57回歯科基礎医学会学術大会
    • Place of Presentation
      朱鷺メッセ(新潟コンベンションセンター)(新潟県新潟市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] B群レンサ球菌のシアル酸分解酵素の分子系統解析と病原性に果たす役割の解析2015

    • Author(s)
      山口雅也,中田匡宣,広瀬雄二郎,後藤花奈,住友倫子,川端重忠
    • Organizer
      日本進化学会第17回大会
    • Place of Presentation
      中央大学後楽園キャンパス(東京都八王子市)
    • Year and Date
      2015-08-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] トリセルラータイトジャンクションを介した化膿レンサ球菌の上皮バリア突破機構の解析2015

    • Author(s)
      住友倫子,中田匡宣,山口雅也,川端重忠
    • Organizer
      第47回レンサ球菌研究会
    • Place of Presentation
      宮崎県市町村職員共済組合 ひまわり荘(宮崎県宮崎市)
    • Year and Date
      2015-07-03
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肺炎球菌の菌体表層タンパクが血中における菌の生存に果たす役割の解明2015

    • Author(s)
      山口 雅也,住友倫子,中田匡宣,川端 重忠
    • Organizer
      近畿腸管微生物研究会総会
    • Place of Presentation
      ホテルグランヴィア大阪(大阪府大阪市)
    • Year and Date
      2015-06-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] Group A Streptococcus penetrates across an epithelial barrier via tricellular tight junctions.2015

    • Author(s)
      Sumitomo T, Nakata M, Yamaguchi M, and Kawabata S.
    • Organizer
      115th General Meeting of American Society for Microbiology.
    • Place of Presentation
      アメリカ合衆国,ニューオリンズ
    • Year and Date
      2015-05-30
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Book] Streptococcal Enolase and Immune Evasion, In Moonlighting proteins: Novel virulence factors in bacterial infections.2017

    • Author(s)
      Masaya Yamaguchi. Shigetada Kawabata
    • Total Pages
      21
    • Publisher
      Wiley-Blackwell
    • ISBN
      9781118951118
    • Related Report
      2017 Annual Research Report
  • [Book] 化学療法の領域.レンサ球菌の病原因子, 特集「改めて考えるレンサ球菌感染症」2017

    • Author(s)
      中田匡宣, 川端重忠
    • Total Pages
      8
    • Publisher
      医薬ジャーナル社
    • Related Report
      2017 Annual Research Report
  • [Book] Streptococcal Enolase and Immune Evasion, In Moonlighting proteins, Novel virulence factors in bacterial infections2017

    • Author(s)
      Yamaguchi M, Kawabata S
    • Publisher
      Wiley Science
    • Related Report
      2016 Annual Research Report
  • [Book] Multiple Roles of Streptococcal Enolase for Bacterial Survival, Moonlightning proteins2016

    • Author(s)
      Yamaguchi M, Kawabata S
    • Publisher
      Wiley Science
    • Related Report
      2015 Annual Research Report
  • [Book] 口腔微生物学・免疫学 第4版 (微生物の歴史と発展)2016

    • Author(s)
      川端重忠,小松澤均,大原直也,寺尾豊,浜田茂幸,中田匡宣 他
    • Total Pages
      303
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report
  • [Book] 口腔微生物学・免疫学 第4版 (微生物の基礎)2016

    • Author(s)
      川端重忠,小松澤均,大原直也,寺尾豊,浜田茂幸,中田匡宣 他
    • Total Pages
      303
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report
  • [Book] 口腔微生物学・免疫学 第4版 (微生物の遺伝学)2016

    • Author(s)
      川端重忠,小松澤均,大原直也,寺尾豊,浜田茂幸,中田匡宣 他
    • Total Pages
      303
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report
  • [Book] 口腔微生物学・免疫学 第4版 (微生物遺伝子の変化)2016

    • Author(s)
      川端重忠,小松澤均,大原直也,寺尾豊,浜田茂幸,中田匡宣 他
    • Total Pages
      303
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report
  • [Book] 口腔微生物学・免疫学 第4版 (微生物遺伝子の応用)2016

    • Author(s)
      川端重忠,小松澤均,大原直也,寺尾豊,浜田茂幸,中田匡宣 他
    • Total Pages
      303
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report
  • [Book] 口腔微生物学・免疫学 第4版 (粘膜免疫)2016

    • Author(s)
      川端重忠,小松澤均,大原直也,寺尾豊,浜田茂幸,中田匡宣 他
    • Total Pages
      303
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report
  • [Book] 口腔微生物学・免疫学 第4版 (グラム陽性球菌と感染症)2016

    • Author(s)
      川端重忠,小松澤均,大原直也,寺尾豊,浜田茂幸,中田匡宣 他
    • Total Pages
      303
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report
  • [Remarks] 大阪大学大学院歯学研究科 口腔細菌学教室

    • URL

      http://web.dent.osaka-u.ac.jp/~mcrbio/

    • Related Report
      2017 Annual Research Report 2016 Annual Research Report
  • [Remarks] 大阪大学大学院歯学研究科 口腔細菌学教室ホームページ

    • URL

      http://web.dent.osaka-u.ac.jp/~mcrbio/index.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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