| Project/Area Number |
15H05037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
Honda Masaki 愛知学院大学, 歯学部, 教授 (70361623)
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| Co-Investigator(Kenkyū-buntansha) |
鳥海 拓 愛知学院大学, 歯学部, 講師 (40610308)
磯川 桂太郎 日本大学, 歯学部, 教授 (50168283)
湯口 眞紀 日本大学, 歯学部, 助手 (00256885)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2015: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | tooth regeneration / neural crest cells / iPS cells / tissue engineering / dentin / cementum / 歯の再生 / iPS細胞 / エナメル質 / 象牙質 / セメント質 / 神経堤細胞 / 再生 / 歯 / 上皮幹細胞 / 歯髄幹細胞 / シュワン細胞 / 骨芽細胞 / 軟骨細胞 / エナメル芽細胞 / 再生医学 / 細胞，組織学 / 歯学 / 発生・分化 / 解剖学 / ヒトiPS細胞 / ヒト歯髄細胞 / 象牙芽細胞 / セメント芽細胞 / 移植 / ブタ歯胚 |
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| Outline of Final Research Achievements |
Tooth development is started from the interaction between epithelial and neural crest derived mesenchymal cells. We try to induce human iPS cells into neural crest cells to develop dental tissues. First, we are successfully induced the human iPS cells into neural crest cells. Then, the dentin and cementum formation are successfully generated from transplanted the combination both neural crest cells and dental epithelial cells in tissue engineering methods. These results indicated that the object in this study are almost achieved during three years.
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