Explication of mechanisms on invasion and metastasis, and prevention of invasion and metastasis of oral squamous cell carcinoma
| Project/Area Number |
15H05042
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中村 博幸 金沢大学, 医学系, 准教授 (30542253)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2016: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Keywords | 口腔扁平上皮癌 / 浸潤 / 転移 / 間質 / 微小環境 / 増殖 / 腫瘍間質 |
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| Outline of Final Research Achievements |
In this study, we investigated the mechanism on invasion and metastasis of oral squamous cell caricinomas (OSCC).
EGFR status may affect the patient response to cetuximab treatment. The analysis of the immunomarker for EGFR, it was revealed that 58.3% of the total cases, and furthermore, that invasiveness was inversely correlated with EGFR expression. Loss of EGFR expression in OSCC was associated with epithelial mesenchymal transition (EMT).
OSCC is highly immunosuppressive, and PD-L1 expression has been proposed as a potential mechanism responsible for this phenotype. Thus, it is important to understand the mechanisms underlying regulation of PD-L1 expression in the OSCC microenvironment. PD-L1 expression in high-grade invasive OSCC was lower than that in a low-grade invasive OSCC and found a close correlation between PD-L1 expression and the EMT. PD-L1 expression was upregulated in macrophages and dendritic cells in high grade invasive human OSCC tissues or co-cultured.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] MicroRNA-205-5p suppresses the invasiveness of oral squamous cell carcinoma by inhibiting TIMP-2 expression.2018
Author(s)
Nagai H, Hasegawa S, Uchida F, Terabe T, Ishibashi Kanno N, Kato K, Yamagata K, Sakai S, Kawashiri S, Sato H, Yanagawa T, Bukawa H.
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Journal Title
International Journal of Oncology
Volume: 52
Pages: 841-850
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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