Analyses of interaction between malaria and intestinal microbiota in patients in Uganda
| Project/Area Number |
15H05274
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 海外学術 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | National Institute of Infectious Diseases (2016-2018)
Gunma University (2015) |
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Principal Investigator |
Hisaeda Hajime 国立感染症研究所, 寄生動物部, 部長 (50243689)
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| Research Collaborator |
Ohno Hiroshi
Miyauchi Eiji
Emmanuel Odongo-Aginya
Olia Alex
Ogwang Martin
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2017: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2015: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | マラリア / ウガンダ / 腸内細菌 / 腸管内寄生虫 |
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| Outline of Final Research Achievements |
We collected more than 300 blood and fecal samples from malaria patients in Uganda from 2015 to 2016 and comprehensively analyzed fecal microbiota. Malaria patients have altered microbiota including change in enterotype compared with non-malarial healthy volunteers, and the degree in alteration was much higher in patients with severe malaria. The microbiota in those patients after treatment became closer to healthy controls. These results indicate that malaria, especially severe malaria affects intestinal microbiota. We also analyzed inflammatory proteins such as cytokines in plasma samples and found some proteins remarkably increased or decreased in severe malaria patients.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで知られていなかったマラリアと腸内細菌の相互作用によるマラリアの病態形成の一端を明らかにできた。プロバイオティクスによる腸内環境の整備が新たな抗マラリア戦略の基盤となることが期待される。また、腸内細菌叢の変化とそれにともなう免疫応答の変調の解明、細菌叢の是正による免疫の正常化手段の確立も考えられ、炎症性疾患の新たな治療法、予防法の確立の確実な足がかりなることも期待できる。
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] A possible origin population of pathogenic intestinal nematodes, Strongyloides stercoralis, unveiled by molecular phylogeny2017
Author(s)
Nagayasu E, Aung MPPTHH, Hortiwakul T, Hino A, Tanaka T, Higashiarakawa M, Olia A, Taniguchi T, Win SMT, Ohashi I, Odongo-Aginya EI, Aye KM, Mon M, Win KK, Ota K, Torisu Y, Panthuwong S, Kimura E, Palacpac NMQ, Kikuchi T, Hirata T, Torisu S, Hisaeda H, Horii T, Fujita J, Htike WW, Maruyama H
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 4844-4844
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis2015
Author(s)
Taniguchi T, Miyauchi E, Nakamura S, Hirai M, Suzue K, Imai T, Nomura T, Handa T, Okada H, Shimokawa C, Onishi R, Olia A, Hirata J, Tomita H, Ohno H, Horii T, Hisaeda H
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Journal Title
Scientific Reports
Volume: 5:15699
Issue: 1
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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