Vaccine candidate discovery for malaria with multiplex assay and cohort study in endemic area.

• Project/Area Number: 15H05282
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Epidemiology and preventive medicine
• Research Institution: Nagasaki University
• Principal Investigator: FUJII Yoshito 長崎大学, 熱帯医学研究所, 准教授 (10404237)
• Co-Investigator(Kenkyū-buntansha): 金子 聰 長崎大学, 熱帯医学研究所, 教授 (00342907) ; 後藤 健介 大阪教育大学, 学校危機メンタルサポートセンター, 准教授 (60423620)
• Research Collaborator: Matilu Mwau ケニア中央医学研究所 ; Samson Muuo Nzou ケニア中央医学研究所 ; Joan Josephine Wangui 長崎大学, 熱帯医学研究所ケニア拠点 ; Anne Mwangi ケニア中央医学研究所
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥14,560,000 (Direct Cost: ¥11,200,000、Indirect Cost: ¥3,360,000); Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2015: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
• Keywords: マラリアワクチン / コホート研究 / マルチプレックス法 / コホート / Luminexマルチプレックス法 / コホート調査

Outline of Final Research Achievements

To identify new vaccine candidate for malaria, we set a research field at a primary school in malaria endemic area in Republic of Kenya. Through 6 months follow-up study about malaria infection targeting all of pupils, we got reliable immunological status to malaria of them. By using collected blood samples, including specific antibodies, it will be possible to identify new vaccine candidates. We will continue this research until it succeeds.

Research Products

• [Int'l Joint Research] Kenya Medical Research Institute(ケニア)
• [Int'l Joint Research] ケニア中央医学研究所(KEMRI )(ケニア)