Exploration of the role of environmental chemical (arsenic) in the development of diabetes and the related metabolic disorders for South Asian Countries

• Project/Area Number: 15H05294
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 海外学術
• Research Field: Metabolomics
• Research Institution: University of Tsukuba
• Principal Investigator: Kawano Satoru 筑波大学, 医学医療系, 講師 (90323295)
• Co-Investigator(Kenkyū-buntansha): 下條 信威 筑波大学, 医学医療系, 講師 (20462210) ; Jesmin Subrina 筑波大学, 人間総合科学研究科, 研究員 (60374261) ; 岡崎 修 国立研究開発法人国立国際医療研究センター, 循環器内科, 医長 (30203970)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000); Fiscal Year 2017: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2016: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2015: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
• Keywords: 南アジア / 糖尿病 / メタボリック症候群 / ヒ素 / メカニズム

Outline of Final Research Achievements

We conducted a cross sectional study (sample size=3351) in rural Bangladesh. We did in depth analysis of non-communicable disease (NCD) risk factors in this study. Diabetes mellitus (DM), the world greatest epidemic, is highly prevalent in arsenic affected population and is increasing over-time (1998: 4.4% vs. current study 13.2% in 2017) in Bangladesh. DM prevalence in arsenic areas is highly dependent on drinking water arsenic concentration. Numbers of arsenic cases were higher in the people whose drinking water has more than 50microgram/L arsenic concentration. DM prevalence in arsenic areas does not depend on the duration of arsenic exposure time or the presence of arsenic skin lesion. Among, 18.2% of the DM participants reported a family history of type 2 DM. Only 45.5% of the participants with T2DM were already diagnosed, with the remaining 54.5% being diagnosed on blood tests during the study.

Research Products

• [Int'l Joint Research] HDRCRP/ボグラ医科大学/Shuvo Diagnostic Center Dhunat(バングラデシュ)
• [Int'l Joint Research] 農村地域住民のための健康と疾病研究センター/ボグラ医科大学/Shuvo Diagnostic Center Dhunat(バングラデシュ)
• [Int'l Joint Research] HDRCRP/Bogra Medical College/Shuvo Diagnostic Center Dhunat(Bangladesh)
• [Journal Article] Hyper-hippocampal glycogen induced by glycogen loading with exhaustive exercise (2018)
  • Author(s): Soya Mariko、Matsui Takashi、Shima Takeru、Jesmin Subrina、Omi Naomi、Soya Hideaki
  • Journal Title: Scientific Reports Volume: - Issue: 1 Pages: 1285-1285
  • DOI: 10.1038/s41598-018-19445-4
  • NAID: 120007134504
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cerebral Tissue Oxygenation Index Using Near-infrared Spectroscopy during Extracorporeal Cardio-pulmonary Resuscitation Predicted Good Neurological Recovery in a Patient with Acute Severe Anemia (2017)
  • Author(s): Koyama Y, Mizutani T, Marushima A, Sonobe A, Shimojo N, Kawano S
  • Journal Title: Internal Medicine Volume: 56 Issue: 18 Pages: 2451-2453
  • DOI: 10.2169/internalmedicine.7826-16
  • NAID: 130006078614
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Development of the Japanese version of the Preschool Confusion Assessment Method for the ICU. (2017)
  • Author(s): Matsuishi Y, Hoshino H, Shimojo N, Enomoto Y, Kido T, Jesmin S, Sumitani M, Inoue Y.
  • Journal Title: Acute Med Surg. Volume: 15;5(1) Issue: 1 Pages: 102-105
  • DOI: 10.1002/ams2.306
  • NAID: 120007134140
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differences in coagulofibrinolytic changes between post-cardiac arrest syndrome of cardiac causes and hypoxic insults: a pilot study. (2017)
  • Author(s): Wada T, Gando S, Mizugaki A, Kodate A, Sadamoto Y, Murakami H, Maekawa K, Katabami K, Ono Y, Hayakawa M, Sawamura A, Jesmin S, Ieko M.
  • Journal Title: Acute Med Surg. Volume: 27;4(3) Issue: 3 Pages: 371-372
  • DOI: 10.1002/ams2.270
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Daily exercise program can improve low HDL level in apparently healthy rural women in Bangladesh. (2017)
  • Author(s): Jesmin, S.; Rahman, M.A.; Islam, M.M.; Kawano, S.; Habib, A.K.M.A.
  • Journal Title: Journal of Shaheed Ziaur Rahman Medical College Volume: 印刷中
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] l Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes. (2017)
  • Author(s): Shima, T.; Matsui, T.; Jesmin, S.; Okamoto, M.; Soya, M.; Inoue, K.; Liu, Y.F.; Torres-Aleman, T.; McEwen, B.S.; Soya, H.
  • Journal Title: Diabetologia Volume: 60(3) Pages: 597-606
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Warning message for arsenic-induced diabetes prevention in rural Bangladesh (2017)
  • Author(s): Jesmin S, Kawano S, Rahman A, Zaedi S, Habib, AKMA
  • Journal Title: Published in sponsored with Bogra Medical College and HDRCRP Volume: - Pages: 1-3
• [Journal Article] Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes. (2017)
  • Author(s): Shima T, Matsui T, Jesmin S, Okamoto M, Soya M, Inoue K, Liu YF, Torres-Aleman I, McEwen BS and Soya H
  • Journal Title: Diabetologia Volume: 60 Issue: 3 Pages: 597-606
  • DOI: 10.1007/s00125-016-4164-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] revalence of metabolic syndrome components among early age onset acute in coronary syndrome patients in Bangladesh. (2016)
  • Author(s): Mamun AA, Jesmin S, Rahman MA, Habib AKMA, Islam MM, Shimojo N, Sultana SN, Sohael F, Okazaki O, Moroi M, Kawano S.
  • Journal Title: Endocrine Practice Volume: 別冊 Pages: 121-121
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] National burden on non-communicable disease risk factors in Bangladesh. (2016)
  • Author(s): Mamun AA, Jesmin S, Rahman MA, Habib AKMA, Islam MM, Sultana SN, Sohael F, Shimojo N, Okazaki O, Kawano S.
  • Journal Title: Endocrine Practice Volume: 別冊 Pages: 182-182
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Gestational diabetes mellitus (GDM) in Bangladesh. (2016)
  • Author(s): Mamun AA, Jesmin S, Rahman MA, Islam MM, Sohael F, Sultana SN, Yamaguchi N, Okazaki O, Kawano S.
  • Journal Title: Endocrine Practice Volume: 別冊 Pages: 233-233
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Differential effects of type 2 diabetes on brain glycometabolism in rats: focus on glycogen and monocarboxylate transporter 2 (2016)
  • Author(s): Shima T, Jesmin S, Matsui T, Soya M, Soya H
  • Journal Title: The Journal of Physiological Sciences Volume: - Issue: 1 Pages: 1-7
  • DOI: 10.1007/s12576-016-0508-6
  • NAID: 40021443633
  • Peer Reviewed / Open Access
• [Journal Article] Nationwide prevalence, awareness, treatment and control of hypertension among the adult population in Bangladesh. (2015)
  • Author(s): S. Jesmin, Y. Iwashima, M.A. Rahman, A.K.M.A. Habib, N. Shimojo, M. Moroi, N. Yamaguchi, O. Okazaki, S. Kawano, Y. Kawano.
  • Journal Title: European Heart Journal Volume: 36(1) Pages: 897-897
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nationwide Non-Communicable Disease Risk Factors Profile in Bangladesh. (2015)
  • Author(s): S. Jesmin, M.A. Rahman, A.K.M.A. Habib, M.M. Islam, S.N. Sultana, S. Zaedi, T. Khatun, F. Sohael, N. Yamaguchi, O. Okazaki, Y. Iwashima, S. Kawano.
  • Journal Title: Journal of Hypertension Volume: 33 Issue: Supplement 2 Pages: 2-2
  • DOI: 10.1097/01.hjh.0000469776.89393.2e
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Prevention of type 2 diabetes mellitus-induced hippocampal cognitive dysfunction from pre-diabetic stage through a 4 months mild exercise regimen. (2018)
  • Author(s): Jesmin, S.; Shima, T.; Takahashi, K.; Omura, K.; Khatun, A.; Matsuishi, Y.; Koizumi, H.; Soya, M1.; Sato, R.; Jangsoo, Y.; Kasane, O.; Matsui, T.; Iwashima, Y.; Yamaguchi, N.; Kawano, S.; Shimojo, N.; Soya, H.
  • Organizer: 2nd General Meeting on Creation and Promotion of WILLDYNAMICS
  • Int'l Joint Research
• [Presentation] Prevention of type 2 diabetes mellitus-induced hippocampal cognitive dysfunction from pre-diabetic stage through a 4 months mild exercise regimen. (2018)
  • Author(s): Jesmin, S.; Shima, T.; Takahashi, K.; Omura, K.; Khatun, A.; Matsuishi, Y.; Koizumi, H.; Soya, M1.; Sato, R.; Jangsoo, Y.; Kasane, O.; Matsui, T.; Iwashima, Y.; Yamaguchi, N.; Kawano, S.; Shimojo, N.; Soya, H.
  • Organizer: International ARIHHP Forum
  • Int'l Joint Research
• [Presentation] 発症前期からの４か月に渡る低強度運動トレーニングは2型糖尿病に伴う海馬機能低下を予防するか？ (2018)
  • Author(s): 荒井サブリナ、島孟留、高橋佳那子、大村航希、アデュリ・ハトゥン、松石雄二郎、小泉光、征矢茉莉子、佐藤崚太、陸暲洙、小倉かさね、松井崇、岩嶋義雄、山口直人、河野了、下條信威、征矢英昭
  • Organizer: 2nd ARIHHP Science week Forum
  • Invited
• [Presentation] Six weeks moderate exercise is effective in ameliorating spatial memory impairment in estrogen-depleted female rat (2017)
  • Author(s): Jesmin, S.; Takahashi, K.; Shima, T.; Matsuishi, Y.; Soya, M.; Yook, J.S.; Ogura, K.; Shimojo, N.; Kawano, S.; Iwashima, Y.; Yamaguchi, N.; Soya, H.
  • Organizer: International ARIHHP Forum Science week
  • Int'l Joint Research
• [Presentation] A relatively longer duration of exercise regimen from pre-diabetes prevents spatial memory impairment with improvement of diabetic symptoms in a type 2 diabetic rat model (2017)
  • Author(s): Jesmin, S.; Shima, T.; Takahashi, K.; Matsuishi, Y.; Soya, M.; Yook, J.S.; Koizumi, H.; Soto, R.; Ogura, K.; Shomojo, N.; Kawano, S.; Iwashima, Y.; Yamaguchi, N.; Soya, H.
  • Organizer: Global Initiative for Sports Neuroscience 2017
  • Int'l Joint Research
• [Presentation] Exercise from pre-diabetes prevents cognitive impairment with improvement of diabetic symptoms in a type 2 diabetic rat model (2017)
  • Author(s): Jesmin, S.; Shima, T.; Takahashi, K.; Omura, K.; Khatun, A.; Matsuishi, Y.; Koizumi, H.; Soya, M.;Sato, R.; Jangsoo, Y.; Kasane, O.; Matsui, T.; Iwashima, Y.; Yamaguchi, N.; Kawano, S.; Shimojo, N.; Soya, H.
  • Organizer: Annual meeting of Japanese Society of Physical Fitness and Sports Medicine
• [Presentation] Six weeks moderate exercise is effective in ameliorating spatial memory impairment in estrogen-depleted female rat (2017)
  • Author(s): Jesmin S, Shima T, Takahashi K, Omura K, Khatun A, Matsuishi Y, Koizumi H, Soya M, Sato R, Jangsoo Y, Kasane O, Matsui T, Iwashima Y, Yamaguchi N, Soya H
  • Organizer: International ARIHHP Forum Science week
  • Int'l Joint Research
• [Presentation] Are we ready to prevent arsenic-induced diabetes in rural Bangladesh? (2017)
  • Author(s): Subrina Jesmin, Saturo Kawano
  • Organizer: Specially arranged symposium at Bogra Medical college
  • Invited
• [Presentation] Age-independent mediation of arsenic in diabetes development in rural Bangladesh (2017)
  • Author(s): Subrina Jesmin, Saturo Kawano
  • Organizer: Specially arranged symposium at HDRCRP
  • Invited
• [Presentation] Effects of endothelin receptor antagonism on VEGF signaling in diabetic penis: A possible clinical implication for diabetes erectile dysfunction. (2016)
  • Author(s): Mamun AA, Jesmin S, Rahman MA, Islam MM, Shimojo N, Sultana SN, Okazaki O, Kawano S.
  • Organizer: The 25th AACE Annual Scientific & Clinical Congress
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2016-05-25
  • Int'l Joint Research
• [Presentation] Diabetes induced cardiac VEGF system in estrogen/estrogen receptor manipulated animal model. (2016)
  • Author(s): Mamun AA, Jesmin S, Rahman MA, Islam MM, Shimojo N, Sultana SN, Yamaguchi N, Okazaki O, Kawano S.
  • Organizer: The 25th AACE Annual Scientific & Clinical Congress
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2016-05-25
  • Int'l Joint Research
• [Presentation] Prevalence of metabolic syndrome components among early age onset acute in coronary syndrome patients in Bangladesh. (2016)
  • Author(s): Mamun AA, Jesmin S, Rahman MA, Habib AKMA, Islam MM, Shimojo N, Sultana SN, Sohael F, Okazaki O, Moroi M, Kawano S.
  • Organizer: The 25th AACE Annual Scientific & Clinical Congress
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2016-05-25
  • Int'l Joint Research
• [Presentation] National burden on non-communicable disease risk factors in Bangladesh. (2016)
  • Author(s): Mamun AA, Jesmin S, Rahman MA, Habib AKMA, Islam MM, Sultana SN, Sohael F, Shimojo N, Okazaki O, Kawano S.
  • Organizer: The 25th AACE Annual Scientific & Clinical Congress
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2016-05-25
  • Int'l Joint Research
• [Presentation] Gestational diabetes mellitus (GDM) in Bangladesh. (2016)
  • Author(s): Mamun AA, Jesmin S, Rahman MA, Islam MM, Sohael F, Sultana SN, Yamaguchi N, Okazaki O, Kawano S.
  • Organizer: The 25th AACE Annual Scientific & Clinical Congress
  • Place of Presentation: Orlando, Florida
  • Year and Date: 2016-05-25
  • Int'l Joint Research
• [Presentation] Nationwide prevalence, awareness, treatment and control of hypertension among the adult population in Bangladesh (2015)
  • Author(s): S. Jesmin, Y. Iwashima, M.A. Rahman, A.K.M.A. Habib, N. Shimojo, M. Moroi, N. Yamaguchi, O. Okazaki, S. Kawano, Y. Kawano.
  • Organizer: ESC Congress 2015
  • Place of Presentation: London ( United Kingdom)
  • Year and Date: 2015-08-29
  • Int'l Joint Research
• [Presentation] Nationwide Assessment of Hypertension Among the Adult Population in Bangladesh (2015)
  • Author(s): M.A. Rahman, S. Jesmin, M.M. Islam, S. Zaedi, A.S.H. Hasan, A.K.M.A. Habib, T. Khatun, S.N. Sultana, N. Yamaguchi, O. Okazaki, S. Kawano, Y. Iwashima. A
  • Organizer: 11th Asia Pacific Congress of Hypertension (APCH 2015)
  • Place of Presentation: Bali (Indonesia)
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] Nationwide Non-Communicable Disease Risk Factors Profile in Bangladesh (2015)
  • Author(s): M.A. Rahman, S. Jesmin, A.K.M.A. Habib, M.M. Islam, S.N. Sultana, S. Zaedi, T. Khatun, F. Sohael, N. Yamaguchi, O. Okazaki, Y. Iwashima, S. Kawano.
  • Organizer: 11th Asia Pacific Congress of Hypertension (APCH 2015)
  • Place of Presentation: Bali (Indonesia)
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] Prevalence of Metabolic syndrome and its components among rural Bangladeshi women (2015)
  • Author(s): M.A. Rahman, S. Jesmin, A.A. Mamun, M.M. Islam, T. Khatun, S.N. Sultana, F. Sohael, S.N. Sultana, A.K.M.A. Habib
  • Organizer: The 2nd SAFES (South Asian Federation of Endocrine Societies) Summit
  • Place of Presentation: Dhaka (Bangladesh)
  • Year and Date: 2015-04-24
  • Int'l Joint Research