Molecular structure design for microbial biosurfactant
| Project/Area Number |
15H05338
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental conscious materials and recycle
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| Research Institution | Kitami Institute of Technology |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2017: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
Fiscal Year 2015: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Keywords | 酵母 / バイオサーファクタント / 界面活性剤 / 表面張力 / 液晶 / 遺伝子破壊 / 代謝工学 / 微生物 / Pseudozyma / 界面活性物質 / 環境材料 / バイオマス / バイオテクノロジー / ゲノム / 糖脂質 / 糖アルコール |
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| Outline of Final Research Achievements |
We focused a smut fungi Pseudozyma hubeiensis as cell factory for producing mannosylerythritol lipids (MEL), which are attractive material as a next generation eco-frendly surface active reagenet. Using genetics and metabolic engineering, non-natural MEL was attempted to produced selectively and efficently by the mutants. Deacetylated MEL (MEL-D) was synthesized by a acetyltransferase-knock out mutant, and was characterized as a surfactant. Furthermore, a novel tryacylated MEL-D was also synthesized.
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Report
(4 results)
Research Products
(13 results)
