Neural circuit mechanisms underlying receptive field formation in higher-order visual cortical areas
| Project/Area Number |
15H05375
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Brain biometrics
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥22,750,000 (Direct Cost: ¥17,500,000、Indirect Cost: ¥5,250,000)
Fiscal Year 2017: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
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| Keywords | 受容野 / DREADD / hM4Di / ウイルスベクター / 視覚弁別課題 / 経路選択的 / 多光子励起イメージング / 神経薬理学 / 2光子励起イメージング / 高次視覚野 / 視床 / 情報処理 / 視覚 / 視覚弁別行動 / 神経回路操作 / 薬理遺伝学 / 逆行性ウイルス / 2光子顕微鏡イメージング / 光遺伝学 / 視床核 / in vivoイメージング / ウイルス遺伝子工学 / 2光子顕微鏡 / カルシウムイメージング / 軸索 / 遺伝学 / Cre / AAV |
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| Outline of Final Research Achievements |
The aim of this project is to reveal how the receptive fields of higher-order visual cortical areas (HVAs) are shaped by the thalamus. We identified synaptic input to the V1 and each HVA by injecting retrograde viruses into each visual area of mice. Neurons of the lateral geniculate nucleus (LGN) neurons project to both the V1 and various HVAs, whereas neurons of the lateral posterior nucleus (LP) project to various HVAs, but not to the V1. We imaged visual responses from axon terminals of the LP or LGN neurons expressing GCaMP6 by 2-photon microscopy. In addition, we imaged visual responses from the V1 or HVA while manipulating activity of neurons in the LP or LGN with the Designer Receptors Exclusively Activated by Designer Drug (DREADD) system. From these results, we conclude that LP neurons play a pivotal role in formation of the receptive fields of HVA neurons in mice.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Distinct Hippocampal Pathways Mediate Dissociable Roles of Context in Memory Retrieval.2016
Author(s)
Xu C, Krabbe S, Gründemann J, Botta P, Fadok JP, Osakada F, Saur D, Grewe BF, Schnitzer MJ, Callaway EM, Lüthi A.
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Journal Title
Cell.
Volume: 167
Issue: 4
Pages: 961-972
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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