| Budget Amount *help |
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2018: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Outline of Final Research Achievements |
As originally planned, we have established a methodology of trans-omics that includes omics layers for gene expression and metabolic flux. This methodology was applied to characterization of metabolic regulation in the mouse liver. We successfully reconstructed a multi-layered metabolic regulatory network in the livers of wild type and obese mice subjected to oral glucose tolerance tests. This is the first full-scale trans-omics analysis using in vivo data in our attempts. In addition, we published several review articles systematically defining the concept and methodology of trans-omics, and its future direction. These review articles, particularly the one on the cover of the April 2016 issue of Trends in Biotechnology, provided further recognition of the methodology.
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