| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2015: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|
|---|
| Outline of Final Research Achievements |
Biofilms can cause chronic infectious diseases upon their formation on medical devices and human tissues. In this study, we aimed to elucidate the mechanisms of biofilm formation in Staphylococcus aureus, Escherichia coli, and other bacteria. We uncovered characteristics and functions of biofilm matrix components such as molecular chaperones and RNA in biofilms formed by S. aureus and other bacteria. In parallel, we found that DnaK chaperone controls the homoeostasis of Curli biogenesis at multiple stages to organize the biofilm matrix. Based on these findings, we developed an efficient strategy to inhibit the biofilm formation. These results provide significant insights for developing anti-biofilm therapies.
|
