Understanding hypothalamic mechanisms in taste modulation with chemogenetic and optogenetic approaches
| Project/Area Number |
15H05624
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | National Institute for Physiological Sciences (2017)
The University of Tokyo (2015-2016) |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
NARUKAWA Masataka
FU Ou
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥12,480,000 (Direct Cost: ¥9,600,000、Indirect Cost: ¥2,880,000)
Fiscal Year 2015: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
|
|---|
| Keywords | 味覚 / 視床下部 / 光遺伝学 / 化学遺伝学 / 食品 / 脳・神経 |
|---|
| Outline of Final Research Achievements |
Food is consisted of both nutrient factors and sensory factors such as taste and smell. Gustatory system plays a critical role in setting a standard to evaluate food quality. By contrast, it is known that this standard is not constant and can change depending on physiological status such as hunger. The mechanism behind this phenomenon, however, remains unclear.
To address this issue, here we manipulate hypothalamic orexigenic neurons to set artificial hunger condition in the mouse brain to analyze the mechanistic insight of hunger-induced taste modification. As a result, the activation of the orexigenic hypothalamic neurons lead to increase in sweet taste sensitivities and to decrease in aversive taste sensitivities, respectively. We revealed that novel role of hypothalamic neurons in taste modulation under hunger.
|
Report
(4 results)
Research Products
(20 results)
-
-
-
[Journal Article] A Novel GPCR-Regulated Neuronal Signaling Pathway Triggers Sustained Orexigenic Effects2016
Author(s)
Nakajima K, Cui Z, Li C, Meister J, Cui Y, Fu Ou, Smith SA, Jain S, Lowell BB, Krashes MJ, and Wess J
-
Journal Title
Nature Communications
Volume: 7
Issue: 1
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Identification of key neoculin residues responsible for the binding and activation of the sweet taste receptor.2015
Author(s)
Koizumi, T., Terada, T., Nakajima, K., Kojima, M., Koshiba, S., Matsumura, Y., Kaneda, K., Asakura, T., Shimizu, A., Abe, K., and Misaka, T.
-
Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 12947-12947
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
