| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2017: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Outline of Final Research Achievements |
Lipid droplet (LDs) are structures with a lipid ester (mainly triacylglycerol or cholesteryl ester) core coated by a phospholipid monolayer. LDs are dynamic organelles involved in intracellular lipid metabolism and energy production. LDs are present in tissue throughout the body, but their size and composition vary greatly. LDs also accumulate in the oocyte cytoplasm during oogenesis. However, the physiological function of LDs remains largely unknown. In our study, by using gene-modified mice and live-imaging system, we found that LD morphology is dynamically changed before and after fertilization. Furthermore, we demonstrated that LDs accumulated in oocytes could be degraded after fertilization by not only cellular lipase but also selective-autophagy.
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