| Budget Amount *help |
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2017: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2016: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2015: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Outline of Final Research Achievements |
Erythrina alkaloids are a group of compounds with a 4-ring structure centered on the spiroamine structure, and are expected to have physiological activity as nicotinic acetylcholine receptor (nAChR) antagonists. Many natural analogs with similar structures are known, each of which has a different partial skeleton with different oxidation states. The authors designed a synthetic late-stage pluripotent intermediate capable of synthesizing these comprehensively, and synthesized it independently by utilizing axial stereochemistry of a medium-membered ring and singlet oxygen oxidation. Asymmetric synthesis of four erythrina alkaloids was achieved for the first time by subsequent conversion. Structural developments have established the basis for the development of new nAChR antagonists.
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