| Budget Amount *help |
¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000)
Fiscal Year 2018: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2017: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
Almost all organisms on Earth have an internal biological clock, the circadian clock. This clock drives stable oscillations in metabolism, physiology, and behavior with a period of approximately 24 h. In mammals, circadian rhythms are generated by a timing system comprised of a master pacemaker located in the suprachiasmatic nucleus (SCN) of the anterior hypothalamus. We previously reported that arginine vasopressin receptor V1a and V1b regulate the speed of re-entrainment after abrupt light/dark advance. Here, we succeeded in real-time monitoring of Per1 and Per2 transcription separately by detecting the bioluminescence of luciferase reporters using a plastic optical fiber inserted into the SCN of freely moving rats. We also presented a new theoretical concept to understand circadian clock disruption and slow recovery from jet lag based on the mathematical model. Finally, we found that rapidly entrainable V1aV1b double knockout mice showed lower mortality under a chronic jet lag.
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