| Budget Amount *help |
¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2018: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
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| Outline of Final Research Achievements |
BTP3-Neu5Ac is a fluorescent imaging reagent for visualizing an enzymatic activity of neuraminidase and was able to histochemically visualize the activity expressed on influenza A and B viruses, some paramyxoviruses, and their infected cells. We developed an imaging method for selectively visualizing viruses and their infected cells possessing a resistance against anti-influenza drug (neuraminidase inhibitor). We also developed an easy and speedy method for sensitively detecting the drug resistance. We established a foundation for structure modifications that could improve properties of BTP3-Neu5Ac.
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