The role of HDOI in the relationship between bone and fat.
Project/Area Number |
15H05646
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
General physiology
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Research Institution | National Cardiovascular Center Research Institute |
Principal Investigator |
Takano Haruko 国立研究開発法人国立循環器病研究センター, 研究所, 研究員 (40532891)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2017: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2016: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2015: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
|
Keywords | 脂肪組織 / ナトリウム利尿ペプチド / 骨形成 / 機械刺激 / 骨膜 / 間葉系幹細胞 / 骨芽細胞 / 伸展刺激 / 生理学 / 運動負荷 / 肥満 / 骨 / ベージュ細胞 |
Outline of Final Research Achievements |
Exercise-induced myokines provide systemic benefits by controlling adipose tissues. However, the relationships between bones and adipose tissues remain to be elucidated. In this study, we analyzed whether periosteum-derived HDOI regulates adipose tissues. After backcrossing to C57BL/6 for 10 generations, we didn’t find any abnormalities in adipose tissues of HDOI-KO mice compared to wild-type mice. Furthermore, HDOI-Tg mice were quite normal in their adipose tissues and showed no metabolic differences even under high-fat diet conditions. Although exercise didn’t induce HDOI directly, mechanical stimulation was required to maintain the expression of HDOI.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Allergic TH2 Response Governed by B-Cell Lymphoma 6 Function in Naturally Occurring Memory Phenotype CD4+ T Cells2018
Author(s)
Takashi Ogasawara,Yuko Kohashi,Jun Ikari,Toshibumi Taniguchi,Nobuhide Tsuruoka,Haruko Watanabe-Takano,Lisa Fujimura,Akemi Sakamoto,Masahiko Hatano,Hirokuni Hirata,Yasutsugu Fukushima,Takeshi Fukuda,Kazuhiro Kurasawa,Koichiro Tatsumi,Takeshi Tokuhisa,Masafumi Arima
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Journal Title
Frontiers in Immunology
Volume: 9
Pages: 750-750
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A New Secretory Peptide of Natriuretic Peptide Family,Osteocrin, Suppresses the Progression of Congestive Heart Failure After Myocardial Infarction.2018
Author(s)
Miyazaki T, Otani K, Chiba A, Nishimura H, Tokudome T, Takano-Watanabe H, Matsuo A, Ishikawa H, Shimamoto K, Fukui H, Kanai Y, Yasoda A, Ogata S, Nishimura K, Minamino N, Mochizuki N.
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Journal Title
Circ Res.
Volume: 122(5)
Issue: 5
Pages: 742-751
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Circulating osteocrin stimulates bone growth by limiting C-type natriuretic peptide clearance.2017
Author(s)
Kanai Y, Yasoda A, Mori KP, Watanabe-Takano H, Nagai-Okatani C, Yamashita Y, Hirota K, Ueda Y, Yamauchi I, Kondo E, Yamanaka S, Sakane Y, Nakao K, Fujii T, Yokoi H, Minamino N, Mukoyama M, Mochizuki N, Inagaki N.
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Journal Title
Journal of Clinical Investigation
Volume: 127
Issue: 11
Pages: 4136-4147
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Development of chronic allergic responses by dampening Bcl6-mediated suppressor activity in memory T helper 2 cells.2017
Author(s)
Ogasawara T, Hatano M, Satake H, Ikari J, Taniguchi T, Tsuruoka N, Watanabe-Takano H, Fujimura L, Sakamoto A, Hirata H, Sugiyama K, Fukushima Y, Nakae S, Matsumoto K, Saito H, Fukuda T, Kurasawa K, Tatsumi K, Tokuhisa T, Arima M.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 114
Issue: 5
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Osteocrin, a secretory peptide from heart, contributes to cranial osteogenesis in zebrafish2016
Author(s)
Chiba A, Watanabe-Takano H, Terai K, Fukui H, Miyazaki T, Uemura M, Hashimoto H, Hibi M, Fukuhara S, Mochizuki N
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Journal Title
Development
Volume: 144
Pages: 334-344
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Transcriptional repression of p27 is essential for murine embryonic development.2016
Author(s)
Teratake Y, Kuga C, Hasegawa Y, Sato Y, Kitahashi M, Fujimura L, Watanabe-Takano H, Sakamoto A, Arima M, Tokuhisa T, Hatano M.
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Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 26244-26244
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Book] 血管医学2015
Author(s)
高野 晴子、千葉 彩乃、宮崎 敬大、望月 直樹
Total Pages
3
Publisher
メディカルレビュー社
Related Report
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