Screening and analysis of glial factors for neuroprotection
| Project/Area Number |
15H05648
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kanemaru Kazunori 東京大学, 大学院医学系研究科(医学部), 助教 (10456105)
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| Co-Investigator(Renkei-kenkyūsha) |
IINO Masamitsu 日本大学, 医学部, 特任教授 (50133939)
OKUBO Yohei 東京大学, 大学院医学系研究科, 講師 (40422282)
SEKIYA Hiroshi 東京大学, 大学院医学系研究科, 助教 (40511374)
TANAKA Kenji 慶應義塾大学, 医学部, 准教授 (30329700)
TACHIKAWA Masanori 東北大学, 大学院薬学研究科, 准教授 (00401810)
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| Research Collaborator |
KITAJIMA Nami 東京大学, 大学院医学系研究科, 大学院生
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2017: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
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| Keywords | アストロサイト / カルシウムシグナル / カルシウムイメージング / 神経保護因子 / 脳損傷 / グリア細胞 / 反応性アストロサイト / 薬理学 / 神経細胞死 |
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| Outline of Final Research Achievements |
In vivo calcium imaging analysis using transgenic mice expressing ultrasensitive calcium indicator in astrocytes revealed that injury-induced astrocytic calcium signals can spread in large area of the brain. This signaling pattern was disappeared in calcium signal deficient mice. Furthermore, we developed new calcium signal deficient mice by astrocyte specific expression of inositol triphosphate hydrolyzing enzyme, IP3 5-phosphatase. Using these transgenic mice, we screened glial calcium-dependent factors for neuroprotection and found that some molecules including glial cytoskeletal proteins may responsible for neuroprotection.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Nitric oxide-induced activation of the type 1 ryanodine receptor is critical for epileptic seizure-induced neuronal cell death.2016
Author(s)
Mikami, Y., Kanemaru, K., Okubo, Y., Nakaune, T., Suzuki, J., Shibata, K., Sugiyama, H., Koyama, R., Murayama, T., Ito, A., Yamazawa, T., Ikegaya, Y., Sakurai, T., Saito, N., Kakizawa, S. and Iino, M.
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Journal Title
EBioMedicine.
Volume: 11
Pages: 253-261
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Genotype-phenotype correlations of malignant hyperthermia and central core disease mutations in the central region of the RYR1 channel.2016
Author(s)
Murayama, T., Kurebayashi, N., Ogawa, H., Yamazawa, T., Oyamada, H., Suzuki, J., Kanemaru, K., Oguchi, K., Iino, M. and Sakurai, T.
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Journal Title
Hum Mutat.
Volume: 37
Issue: 11
Pages: 1231-1241
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Visualization of Ca2+ filling mechanisms upon synaptic inputs in the endoplasmic reticulum of cerebellar Purkinje cells.2015
Author(s)
Okubo, Y., Suzuki, J., Kanemaru, K., Nakamura, N., Shibata, T. and *Iino, M.
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Journal Title
J. Neurosci.
Volume: 35
Issue: 48
Pages: 15837-15846
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Neuronal regulation of Schwann cell mitochondrial Ca2+ Signaling during myelination.2015
Author(s)
Ino, D., Sagara, H., Suzuki, J., Kanemaru, K., Okubo, Y., and *Iino, M.
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Journal Title
Cell Rep.
Volume: 12
Issue: 12
Pages: 1951-1959
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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