Research Project
Grant-in-Aid for Young Scientists (A)
In vivo calcium imaging analysis using transgenic mice expressing ultrasensitive calcium indicator in astrocytes revealed that injury-induced astrocytic calcium signals can spread in large area of the brain. This signaling pattern was disappeared in calcium signal deficient mice. Furthermore, we developed new calcium signal deficient mice by astrocyte specific expression of inositol triphosphate hydrolyzing enzyme, IP3 5-phosphatase. Using these transgenic mice, we screened glial calcium-dependent factors for neuroprotection and found that some molecules including glial cytoskeletal proteins may responsible for neuroprotection.
All 2018 2017 2016 2015
All Journal Article (11 results) (of which Int'l Joint Research: 3 results, Peer Reviewed: 8 results, Open Access: 5 results, Acknowledgement Compliant: 3 results) Presentation (12 results) (of which Int'l Joint Research: 3 results, Invited: 1 results)
Antioxid Redox Signal (in press)
Volume: - Issue: 12 Pages: 1147-1157
10.1089/ars.2018.7498
生化学
Volume: 88 Issue: 1 Pages: 128-134
10.14952/SEIKAGAKU.2016.880128
Eur. J. Neurosci
Volume: 44 Pages: 2004-2014
EBioMedicine.
Volume: 11 Pages: 253-261
10.1016/j.ebiom.2016.08.020
Biophys J.
Volume: 111 Issue: 6 Pages: 1119-1131
10.1016/j.bpj.2016.04.054
Hum Mutat.
Volume: 37 Issue: 11 Pages: 1231-1241
10.1002/humu.23072
日本薬理学雑誌
Volume: 147 Pages: 190-193
130005143836
J. Neurosci.
Volume: 35 Issue: 48 Pages: 15837-15846
10.1523/jneurosci.3487-15.2015
Cell Rep.
Volume: 12 Issue: 12 Pages: 1951-1959
10.1016/j.celrep.2015.08.039
PLoS One
Volume: 10 Issue: 6 Pages: e0130606-e0130606
10.1371/journal.pone.0130606
生体の科学
Volume: 66(6) Pages: 546-550