Elucidation of the mechanisms of the slow processes of development, growth and senescence in the longest-lived rodent, the naked mole rat.
| Project/Area Number |
15H05649
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
Miura Kyoko 北海道大学, 遺伝子病制御研究所, 招へい教員 (80583062)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000)
Fiscal Year 2017: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
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| Keywords | ハダカデバネズミ / naked mole rat / 細胞増殖 / 老化 |
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| Outline of Final Research Achievements |
The naked mole rat (NMR) is the longest-living rodent in the world and has extraordinary cancer-resistance. We studied the mechanisms of slow processes of development, growth and senescence in the NMR. We found that temperature and other factors may contribute to slow proliferation of the NMR somatic cells. NMR-iPS cells did not show shortening of G1 phase and acceleration of proliferation compared to the parental skin fibroblasts. We also found a mechanism of NMR-specific metabolic regulation which would contribute to slow proliferation of the NMR somatic cells. Moreover, we also performed functional analysis of the NMR brown adipose tissues.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Tumour resistance in induced pluripotent stem cells derived from naked mole-rats2016
Author(s)
Miyawaki S, Kawamura Y, Oiwa Y, Shimizu A, Hachiya T, Bono H, Koya I, Okada Y, Kimura T, Yoshihiro Tsuchiya, Suzuki S, Onishi N, Kuzumaki N, Matsuzaki Y, Narita M, Ikeda E, Okanoya K, Seino K, Saya H, Okano H & Miura K
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Journal Title
Nature Communications
Volume: 7
Issue: 1
Pages: 11471-11471
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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