| Budget Amount *help |
¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2018: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
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| Outline of Final Research Achievements |
In the present study, we tried to do develop the newly bio-imaging probe, which based on the antibody and observed molecular function, and intracellular delivery system, and validate the functionality and availability of the probes. These probes were originally designed and developed by the opto-engineering techniques using luciferase and other light-sensitive molecules, which allowed us to observe and control the molecular functions non-invasively and continuously. By these newly developed tools, we spatio-temporally succeeded in visualization and evaluation of cell survival- and death-associated signals and to control cellular function.
These results will provide important perspectives on the potential pathological and therapeutic roles of molecular signals in cancer and other diseases and contribute to the development of more effective drugs in shorter periods.
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