Optimization of human iPS cell derived liver bud transplantation

• Project/Area Number: 15H05677
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: Yokohama City University
• Principal Investigator: TAKEBE Takanori 横浜市立大学, 先端医科学研究センター, 教授 (20612625)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000); Fiscal Year 2017: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2016: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2015: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
• Keywords: 再生医学 / 移植外科学 / 移植 / 肝臓原基

Outline of Final Research Achievements

Organoid technology provides a revolutionary paradigm towards therapy, yet to be applied in humans mainly because of the reproducibility and scalability challenges. Here, we overcome these limitations by evolving scalable organ bud production platform entirely from human iPSC. First, we identified effective progenitor populations for generating liver buds in a highly reproducible manner: hepatic endoderm, endothelium and septum mesenchyme. Furthermore, we achieved human scalability by developing an omni-well-array culture platform for mass-producing homogenous and miniaturized liver buds on a large scale (>108-scale). Vascularized and functional liver tissues generated entirely from iPSC significantly improved subsequent hepatic functionalization, enabling functional rescue against acute liver failure via transplantation. Overall, our study provides a stringent manufacture platform for multi-cellular organoid supply, thus facilitating clinical and pharmaceutical applications.

Research Products

• [Journal Article] Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic (2018)
  • Author(s): Yoshinobu Takahashi, Keisuke Sekine, Tatsuya Kin, Takanori Takebe, Hideki Taniguchi
  • Journal Title: Cell Reports Volume: 6 Issue: 6 Pages: 1620-1629
  • DOI: 10.1016/j.celrep.2018.03.123
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells. (2017)
  • Author(s): Takebe T*, Sekine K, Kimura M, Yoshizawa E, Funayama S, Nakanishi N, Hisai T, Kobayashi T, Mori A, Ayano S, Ejiri Y, Amimoto N, Yamazaki Y, Ogawa S, Ishikawa M, Kiyota Y, Ueno Y, Taniguchi H
  • Journal Title: Cell Reports Volume: 21 Issue: 10 Pages: 2661-2670
  • DOI: 10.1016/j.celrep.2017.11.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Multilineage communication regulates human liver bud self-organization from pluripotency. (2017)
  • Author(s): Camp JG, Sekine K, Gerber T, Loeffler-Wirth H, Binder H, Gac M, Kanton S, Kageyama J, Damm G, Seehofer D, Belicova L, Bickle M, Barsacchi R, Okuda R, Yoshizawa E, Kimura M, Ayabe H, Taniguchi H, Takebe T*, Treutlein B
  • Journal Title: Nature Volume: 546 Issue: 7659 Pages: 533-534
  • DOI: 10.1038/nature22796
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Liver Regeneration Using Cultured Liver Bud (2017)
  • Author(s): Sekine K, Takebe T, Taniguchi H.
  • Journal Title: Methods Mol Biol Volume: 1597 Pages: 207-216
  • DOI: 10.1007/978-1-4939-6949-4_15
  • ISBN: 9781493969470, 9781493969494
  • Peer Reviewed / Open Access
• [Journal Article] Synergistic engineering: Organoids meet organs-on-a-chip (2017)
  • Author(s): Takebe T*, Zhang B, Milica R
  • Journal Title: Cell Stem Cell Volume: 21(3) Issue: 3 Pages: 297-300
  • DOI: 10.1016/j.stem.2017.08.016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nutritional modulation of mouse and human liver bud growth through a branched-chain amino acid metabolism. (2017)
  • Author(s): Koike H, Zhang RR, Ueno Y, Sekine K, Zheng YW, Takebe T, Taniguchi H.
  • Journal Title: Development Volume: 144(6) Pages: 1018-1024
  • DOI: 10.1242/dev.143032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Multilineage communication regulates human liver bud self-organization from pluripotency. (2017)
  • Author(s): Camp JG, Sekine K, Gerber T, Loeffler-Wirth H, Binder H, Gac M, Kanton S, Kageyama J, Damm G, Seehofer D, Belicova L, Bickle M, Barsacchi R, Okuda R, Yoshizawa E, Kimura M, Ayabe H, Taniguchi H, Takebe T, Treutlein B
  • Journal Title: Nature Volume: -
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Paracrine signals regulate human liver organoid maturation from induced pluripotent stem cells. (2017)
  • Author(s): Asai A, Aihara E, Mizuochi T, Phelan K, Mayhew C, Shivakumar P, Takebe T, Wells J, Bezerra J
  • Journal Title: Development Volume: 144（6） Pages: 1056-1064
  • DOI: 10.1242/dev.142794
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Autotransplantation of monkey ear perichondrium-derived progenitor cells for cartilage reconstruction. (2016)
  • Author(s): Kagimoto S, Takebe T*, Kobayashi S, Yabuki Y, Hori A, Hirotomi K, Mikami T, Uemura T, Maegawa J, Taniguchi H
  • Journal Title: Cell transplantation Volume: 25（5） Issue: 5 Pages: 951-962
  • DOI: 10.3727/096368916x690917
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation (2015)
  • Author(s): T. Takebe, M. Eomura, E. Yoshizawa, M. Kimura, H. Koike, Y. Ueno, T. Matsuzaki, T. Yamazaki, T. Toyohara, K. Osafune, H. Nakauchi, H. Y. Yoshikawa, H. Taniguchi
  • Journal Title: Cell Stem Cell Volume: 16 Issue: 5 Pages: 556-565
  • DOI: 10.1016/j.stem.2015.03.004
  • Peer Reviewed / Open Access
• [Presentation] ヒトオルガノイドを用いたホロミクス研究の可能性 (2018)
  • Author(s): 武部貴則
  • Organizer: 多次元生命システム研究戦略分子・細胞アトラスに関する意見交換会 JST研究開発戦略センター（CRDS）ライフサイエンス・臨床医学ユニット
  • Invited
• [Presentation] 研究の未来を考えよう (2018)
  • Author(s): 武部貴則
  • Organizer: 再生医療学会総会市民公開講座
  • Invited
• [Presentation] 再生医学ｘ広告医学－0から1への挑戦 (2018)
  • Author(s): 武部貴則
  • Organizer: 01 Doctor Initiative
  • Invited
• [Presentation] ヒト肝炎オルガノイドを用いたホロミクス研究 (2018)
  • Author(s): 武部貴則
  • Organizer: 再生医療学会シンポジウム
  • Invited
• [Presentation] 次世代オルガノイド研究の展望 The era of Organoid Medicine (2018)
  • Author(s): 武部貴則
  • Organizer: 再生医療学会シンポジウム
  • Invited
• [Presentation] ヒト器官原基法に基づく移植医療応用への試み (2018)
  • Author(s): 武部貴則
  • Organizer: 再生医療学会シンポジウム
  • Invited
• [Presentation] 臓器再生への挑戦！ (2018)
  • Author(s): 武部貴則
  • Organizer: 第３回Koishikawa Seminar
  • Invited
• [Presentation] 次世代オルガノイド研究の展望 The era of Organoid Medicine (2018)
  • Author(s): 武部貴則
  • Organizer: 農芸化学シンポジウム
  • Invited
• [Presentation] The era of Organoid Medicine - Liver Organoid Based Approach (2018)
  • Author(s): Takebe Takanori
  • Organizer: Southern California Stem Cell Seminar Series
  • Int'l Joint Research / Invited
• [Presentation] 次世代オルガノイド研究と創生医学-The era of Organoid Medicine- (2018)
  • Author(s): 武部貴則
  • Organizer: 理研 CDB-大塚製薬連携センター 第 2 回合同セミナー
  • Invited
• [Presentation] 歩きたくなる階段ツアー (2018)
  • Author(s): 武部貴則
  • Organizer: 横浜市立大学教員向け Staff Development研修
• [Presentation] The era of Organoid Medicine4.0 (2018)
  • Author(s): Takebe Takanori
  • Organizer: Regenerative Biology and Stem Cell Seminar Series Northwestern University
  • Int'l Joint Research / Invited
• [Presentation] 2 Lives - Future of Healthcare (2017)
  • Author(s): 武部貴則
  • Organizer: 第2回 01 Doctor Initiative
  • Place of Presentation: The Place of Tokyo(東京都港区）
  • Year and Date: 2017-05-18
  • Invited
• [Presentation] ヒト臓器創出への挑戦 (2017)
  • Author(s): 武部貴則
  • Organizer: 久留米大学講演
  • Place of Presentation: 久留米大学（福岡県久留米市）
  • Year and Date: 2017-05-12
  • Invited
• [Presentation] ミニ臓器技術を核とした産業形成への展望 (2017)
  • Author(s): 武部貴則
  • Organizer: CPhI / ICSE / P-MEC / BioPh / InnoPack Japan 2017
  • Place of Presentation: 東京ビックサイト（東京都江東区）
  • Year and Date: 2017-04-20
  • Invited
• [Presentation] Human Organ Bud Generation From Stem Cell Towards Therapy (2017)
  • Author(s): Takebe T
  • Organizer: Liver Seminar Series, Albert Eistein Colledge of Medicine
  • Place of Presentation: NYC, USA
  • Year and Date: 2017-04-05
  • Int'l Joint Research / Invited
• [Presentation] iPS細胞が創る新しい社会 (2017)
  • Author(s): 武部貴則
  • Organizer: 「医学を志す」講演会
  • Place of Presentation: 聖光学院（神奈川県横浜市）
  • Year and Date: 2017-03-19
  • Invited
• [Presentation] 器官創出技術を用いた医療応用への展望 (2017)
  • Author(s): 武部貴則
  • Organizer: 愛媛大講演
  • Place of Presentation: 愛媛大学（愛媛県松山市）
  • Year and Date: 2017-03-16
  • Invited
• [Presentation] De novo generation of diverse organ buds from stem cells (2017)
  • Author(s): Takebe T
  • Organizer: KEYSTONE SYMPOSIA ON Molecular and Cellular Biology
  • Place of Presentation: Boston, USA
  • Year and Date: 2017-03-09
  • Int'l Joint Research / Invited
• [Presentation] De novo generation of diverse organ buds from stem cells. (2017)
  • Author(s): Takebe T
  • Organizer: Endocrinology Seminar Cincinnati
  • Place of Presentation: Cincinnati, USA
  • Year and Date: 2017-02-10
  • Int'l Joint Research / Invited
• [Presentation] ミニ臓器創出技術を核とする戦略的iPS細胞研究 (2017)
  • Author(s): 武部貴則
  • Organizer: 平成２８年度先導技術交流会シンポジウム
  • Place of Presentation: 東京国立研究開発法人産業技術総合研究所臨海副都心センター（東京都江東区）
  • Year and Date: 2017-02-01
  • Invited
• [Presentation] ミニ臓器創出と臨床応用 (2017)
  • Author(s): 武部貴則
  • Organizer: 新化学技術推進協会（JACI）講演会
  • Place of Presentation: 新化学技術推進協会（東京都千代田区）
  • Year and Date: 2017-01-23
  • Invited
• [Presentation] 臓器創出への展望2020 (2017)
  • Author(s): 武部貴則
  • Organizer: 小野薬品工業株式会社
  • Invited
• [Presentation] オルガノイド技術を用いたヒト肝臓発生の理解と制御 (2017)
  • Author(s): 武部貴則
  • Organizer: 第４０回日本分子生物学会総会
  • Invited
• [Presentation] 臓器創出への挑戦 (2017)
  • Author(s): 武部貴則
  • Organizer: 弘前大学 先端医療に携わる人材育成事業セミナー
  • Invited
• [Presentation] 臓器創出への展望 (2017)
  • Author(s): 武部貴則
  • Organizer: 東京医科歯科大学 平成29年度第1回 統合研究機構先端研究セミナー
  • Invited
• [Presentation] Growing organ bud towards therapy (2017)
  • Author(s): 武部貴則
  • Organizer: New York Stem Cell Foundation Annual meeting
  • Int'l Joint Research / Invited
• [Presentation] Growing organ bud towards therapy (2017)
  • Author(s): Takebe Takanori
  • Organizer: The 27th Hot Spring Harbor International Symposium, Frontiers in Stem Cell Research and Reprogramming
  • Int'l Joint Research / Invited
• [Presentation] Organoid biology and regenerative medicine (2017)
  • Author(s): Takebe Takanori
  • Organizer: 1st Joint Meeting on Health and Medical Care between Thailand and Japan
  • Int'l Joint Research / Invited
• [Presentation] 臓器再生への展望 (2017)
  • Author(s): 武部貴則
  • Organizer: 日興コーディアル証券株式会社
  • Invited
• [Presentation] Organ Bud Based Approach Towards Therapy (2017)
  • Author(s): 武部貴則
  • Organizer: 理研CLST Educationalセミナー
  • Invited
• [Presentation] Future of Heathcare2020 (2017)
  • Author(s): 武部貴則
  • Organizer: 大成建設株式会社
  • Invited
• [Presentation] iPS細胞由来ミニ肝臓を用いた再生医療 (2017)
  • Author(s): 武部貴則
  • Organizer: 第38回日本炎症・再生医学会シンポジウム
  • Invited
• [Presentation] iPS細胞由来ミニ肝臓と血漿蛋白産生 (2017)
  • Author(s): 武部貴則
  • Organizer: 第65回日本輸血・細胞治療学会講演
  • Invited
• [Presentation] Human Liver Bud Transplantation Towards Therapy (2017)
  • Author(s): Takebe Takanori
  • Organizer: ISSCR 2017 ANNUAL MEETING
  • Int'l Joint Research / Invited
• [Presentation] Human Organoid Based Approach Towards Therapy (2017)
  • Author(s): Takebe Takanori
  • Organizer: Boston Takeda RMU day
  • Int'l Joint Research / Invited
• [Presentation] 2 Lives - Future of Healthcare- (2017)
  • Author(s): 武部貴則
  • Organizer: 第2回 01 Doctor Initiative
  • Invited
• [Presentation] ヒト臓器創出への挑戦 (2017)
  • Author(s): 武部貴則
  • Organizer: 久留米大学
• [Presentation] ミニ臓器技術を核とした産業形成への展望 (2017)
  • Author(s): 武部貴則
  • Organizer: CPhI / ICSE / P-MEC / BioPh / InnoPack国際医薬中間体展
  • Invited
• [Presentation] ヒト器官原基法に基づく移植医療応用への試み (2017)
  • Author(s): 武部貴則
  • Organizer: 第19回外科分子細胞治療研究会
  • Invited
• [Presentation] Human Organ Bud Generation From Stem Cell Towards Therapy (2017)
  • Author(s): Takebe Takanori
  • Organizer: Albert Eistein College of Medicine
  • Int'l Joint Research / Invited
• [Presentation] Radial Prototyping-ヒト臓器創出へ向けて－ (2016)
  • Author(s): 武部貴則
  • Organizer: 大日本住友製薬講演
  • Place of Presentation: 大日本住友製薬株式会社大阪研究所（大阪府大阪市）
  • Year and Date: 2016-12-06
  • Invited
• [Presentation] Modeling human organ development (2016)
  • Author(s): 武部貴則
  • Organizer: 2016 年 東西合同スクリフス会講演
  • Place of Presentation: TKP東京駅八重洲カンファレンスセンター（東京都中央区）
  • Year and Date: 2016-12-03
  • Invited
• [Presentation] 臓器形成におけるヘテロジェネイティの理解と制御 (2016)
  • Author(s): 武部貴則
  • Organizer: 日本分子生物学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-11-30
  • Invited
• [Presentation] Regenerative Medicine Frontline - Tissues and organs (2016)
  • Author(s): Takebe T
  • Organizer: 2016 World Alliance Forum
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2016-11-21
  • Int'l Joint Research / Invited
• [Presentation] iPS細胞由来ミニ臓器移植によるヒト臓器の創出 (2016)
  • Author(s): 武部貴則
  • Organizer: 都医学研セミナー
  • Place of Presentation: 東京都医学総合研究所（東京都世田谷区）
  • Year and Date: 2016-11-18
  • Invited
• [Presentation] Engineering Liver Via iPSC (2016)
  • Author(s): Takebe T
  • Organizer: 2016 Basic Research Workshop American Association for Study of Liver Disease Annual meeting
  • Place of Presentation: Boston, USA
  • Year and Date: 2016-11-17
  • Int'l Joint Research / Invited
• [Presentation] De novo generation of diverse organ buds from stem cells. (2016)
  • Author(s): Takebe T
  • Organizer: EMBL Conference for Organoids: Modelling Organ Development and Disease in 3D Culture
  • Place of Presentation: Heidelberg, Germany
  • Year and Date: 2016-10-12
  • Int'l Joint Research / Invited
• [Presentation] Generating organ buds towards therapy (2016)
  • Author(s): takebe T
  • Organizer: From Stem Cells to Human Development Company of Biologists
  • Place of Presentation: Southbridge, MA, USA
  • Year and Date: 2016-09-25
  • Int'l Joint Research / Invited
• [Presentation] 器官原基移植によるヒト臓器創出への挑戦 (2016)
  • Author(s): 武部貴則
  • Organizer: 小児消化器栄養肝臓学会
  • Place of Presentation: つくば国際会議場（茨城県つくば市）
  • Year and Date: 2016-09-17
  • Invited
• [Presentation] ミニ臓器と臨床応用 (2016)
  • Author(s): 武部貴則
  • Organizer: JASIS 2016 サイエンスイノベーションゾーン
  • Place of Presentation: 幕張メッセ（千葉県千葉市）
  • Year and Date: 2016-09-08
  • Invited
• [Presentation] 多細胞系からなる複雑なヒト臓器の人為的創出 (2016)
  • Author(s): 武部貴則
  • Organizer: 化学とマイクロ・ナノシステム学会
  • Place of Presentation: 幕張メッセ（千葉県千葉市）
  • Year and Date: 2016-09-06
  • Invited
• [Presentation] 次世代のヘルスケア基盤創出 (2016)
  • Author(s): 武部貴則
  • Organizer: 大塚製薬薬局薬店特別講演
  • Place of Presentation: 大塚製薬株式会社徳島研究所（徳島県徳島市）
  • Year and Date: 2016-07-19
  • Invited
• [Presentation] 次世代のヘルスケア産業基盤創出 (2016)
  • Author(s): Takebe T
  • Organizer: Word Alliance Forum executive club
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2016-06-29
  • Int'l Joint Research / Invited
• [Presentation] De novo generation of diverse organ buds towards therapy (2016)
  • Author(s): Takebe T
  • Organizer: De novo generation of diverse organ buds towards therapy
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2016-06-25
  • Int'l Joint Research / Invited
• [Presentation] ヒトiPS細胞由来器官原基移植療法の開発 (2016)
  • Author(s): 武部貴則
  • Organizer: 日本炎症・再生医学会シンポジウム４
  • Place of Presentation: 京都みやこめっせ（京都府京都市）
  • Year and Date: 2016-06-16
  • Invited
• [Presentation] 器官原基移植によるヒト臓器創出への展望 (2016)
  • Author(s): 武部貴則
  • Organizer: 信濃町循環器セミナー
  • Place of Presentation: 慶應義塾大学（東京都新宿区）
  • Year and Date: 2016-06-14
  • Invited
• [Presentation] ヒトiPS細胞由来器官原基移植療法の開発 (2016)
  • Author(s): 武部貴則
  • Organizer: 第61回日本透析医学会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2016-06-12
  • Invited
• [Presentation] 多細胞系からなる複雑なヒト臓器の人為的構成 (2016)
  • Author(s): 武部貴則
  • Organizer: 先端医療振興財団 H28神戸再生医療勉強会
  • Place of Presentation: 神戸臨床研究情報センター（兵庫県神戸市）
  • Year and Date: 2016-05-30
  • Invited
• [Presentation] iPS細胞を用いたヒト代謝性臓器の創出 (2016)
  • Author(s): 武部貴則
  • Organizer: 第63回日本実験動物学会総会
  • Place of Presentation: ミューザ川崎シンフォニーホール（神奈川県川崎市）
  • Year and Date: 2016-05-19
  • Invited
• [Presentation] 臓器創出への展望 (2016)
  • Author(s): 武部貴則
  • Organizer: 大塚製薬講演
  • Place of Presentation: 大塚ホールディングス株式会社（東京都港区）
  • Year and Date: 2016-05-16
  • Invited
• [Presentation] iPS細胞由来器官原基移植によるヒト臓器の創出 (2016)
  • Author(s): 武部貴則
  • Organizer: 第64回日本輸血・細胞治療学会総会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2016-04-30
  • Invited
• [Presentation] 器官創出技術を用いた医療応用への展望 (2016)
  • Author(s): 武部貴則
  • Organizer: 第102回日本消化器病学会総会
  • Place of Presentation: 京王プラザホテル（東京都新宿区）
  • Year and Date: 2016-04-22
  • Invited
• [Presentation] Generation of Diverse Organ Buds from Human iPSCs. (2016)
  • Author(s): Takebe T
  • Organizer: French Society for Cell and Gene Therapy
  • Place of Presentation: Marseille, France
  • Year and Date: 2016-03-14
  • Int'l Joint Research / Invited
• [Presentation] 血管構造を有する 複雑なヒト臓器の人為的構成 (2015)
  • Author(s): 武部貴則
  • Organizer: 分生・生化学会
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-12-01
  • Int'l Joint Research / Invited
• [Presentation] Generating diverse organ buds from stem cells. (2015)
  • Author(s): Takebe T
  • Organizer: JST CREST-PRESTO joint international symposium
  • Place of Presentation: 東京大学（東京都文京区）
  • Year and Date: 2015-11-05
  • Int'l Joint Research / Invited
• [Presentation] Human iPSC-derived organ bud based approaches. (2015)
  • Author(s): Takebe T
  • Organizer: 112th ITC(INTERNATIONAL TITISEE CONFERENCE
  • Place of Presentation: Mainz, Germany
  • Year and Date: 2015-10-22
  • Int'l Joint Research / Invited
• [Presentation] In vitro reconstructions and controls of multicellular structures. (2015)
  • Author(s): Takebe T
  • Organizer: The 26th CDB Meeting Mechanistic Perspectives of Multicellular Organization
  • Place of Presentation: 理化学研究所 多細胞システム形成研究センター（兵庫県神戸市）
  • Year and Date: 2015-09-08
  • Int'l Joint Research / Invited
• [Presentation] De novo generation of liver buds from stem cells. (2015)
  • Author(s): Takebe T
  • Organizer: International Conference of Future Hepatology at Kaohsiung
  • Place of Presentation: Kaohsiung, Taiwan
  • Year and Date: 2015-07-25
  • Int'l Joint Research / Invited
• [Presentation] De novo generation of diverse organ buds from iPSCs towards therapy. (2015)
  • Author(s): Takebe T
  • Organizer: ISSCR 2015 ANNUAL MEETING
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2015-06-26
  • Int'l Joint Research / Invited
• [Presentation] Realization of human iPSC-derived liver bud transplantation therapy. (2015)
  • Author(s): Takebe T
  • Organizer: the Young Investigators’ Stem Cell Symposium 2015
  • Place of Presentation: Biopolis, Singapore
  • Year and Date: 2015-06-08
  • Int'l Joint Research / Invited
• [Presentation] 臨床応用の基盤形成を目指した肝再生研究の新展開 (2015)
  • Author(s): 武部貴則
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: ホテル日航熊本（熊本県熊本市）
  • Year and Date: 2015-05-22
  • Int'l Joint Research / Invited
• [Presentation] Regenerative approaches through developmental biology. (2015)
  • Author(s): Takebe T
  • Organizer: EASL, 50th the International Liver Congress
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2015-04-22
  • Int'l Joint Research / Invited
• [Presentation] Human iPSC-derived organ bud based approaches towards clinical application. (2015)
  • Author(s): Takebe T
  • Organizer: 8th Pan Pacific Symposium 2015 on Stem Cells and Cancer Research
  • Place of Presentation: Hsinchu, Taiwan
  • Year and Date: 2015-04-11
  • Int'l Joint Research
• [Book] 『挑む！化学を拓く28人』再生医療研究のホープｉＰＳ細胞から臓器を作る (2017)
  • Author(s): 武部貴則、他著
  • Total Pages: 247
  • Publisher: 日本経済新聞出版社
  • ISBN: 9784532520731
• [Book] オルガノイド4.0時代 次世代のオルガノイド研究のデザイン (2017)
  • Author(s): 武部貴則
  • Total Pages: 139
  • Publisher: 実験医学
  • ISBN: 9784758125000
• [Book] 小児内科 Vol.49 (2017)
  • Author(s): 武部貴則
  • Total Pages: 100
  • Publisher: 東京医学社
• [Book] Reverse Engineering Organ Buds through Self-Driven Condensation and Organization. (2017)
  • Author(s): Shinozawa T, Yoshikawa H-Y, Takebe T
  • Total Pages: 8
  • Publisher: Developmental Biology
• [Book] Rational design of mechanical environment for self-organizing organ bud (2017)
  • Author(s): 松崎賢寿，吉川洋史，谷口英樹，武部貴則
  • Total Pages: 3
  • Publisher: 日本バイオマテリアル学会誌
• [Book] Impact of mechanical environment on cell adhesion regulating biological process (2017)
  • Author(s): 松崎賢寿，吉川洋史，谷口英樹，武部貴則
  • Total Pages: 5
  • Publisher: 化学とマイクロ・ナノシステム学会誌
• [Book] Engineering pancreatic tissues from stem cells towards therapy. (2016)
  • Author(s): Takahashi Y, Takebe T, Taniguchi H
  • Total Pages: 9
  • Publisher: Regenerative Therapy
• [Book] iPS由来器官原基移植による機能的なヒト肝臓の創出 (2015)
  • Author(s): 谷口英樹、武部貴則
  • Total Pages: 18
  • Publisher: 最新医学
• [Book] 肝胆膵 (2015)
  • Author(s): 谷口英樹、武部貴則
  • Total Pages: 8
  • Publisher: アークメディア
• [Book] 月刊 糖尿病 DIABETES (2015)
  • Author(s): 谷口英樹、武部貴則
  • Total Pages: 7
  • Publisher: 医学出版
• [Book] 膵島の再生医療－膵β細胞の発生と再生をめぐる新展開－ (2015)
  • Author(s): 谷口英樹、武部貴則
  • Total Pages: 5
  • Publisher: 診断と治療
• [Book] Annual Review 2015 糖尿病・代謝・内分泌 (2015)
  • Author(s): 武部貴則、谷口英樹
  • Total Pages: 6
  • Publisher: 中外医学
• [Patent(Industrial Property Rights)] digitalized human organoids and methods of using same. (2017)
  • Inventor(s): 1Takebe T, Kimura M
  • Industrial Property Rights Holder: 1Takebe T, Kimura M
  • Industrial Property Rights Type: 特許
  • Filing Date: 2017
  • Overseas
• [Patent(Industrial Property Rights)] 細胞選別法 (2017)
  • Inventor(s): 松﨑賢寿，谷口英樹，武部貴則
  • Industrial Property Rights Holder: 松﨑賢寿，谷口英樹，武部貴則
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2017-043744
  • Filing Date: 2017-03-08
• [Patent(Industrial Property Rights)] 培養方法及び細胞塊 (2015)
  • Inventor(s): 谷口英樹、武部貴則、江尻洋子
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-05-29
  • Overseas
• [Patent(Industrial Property Rights)] 細胞培養システム (2015)
  • Inventor(s): 谷口英樹、武部貴則、関根圭輔、砂山裕信、西村哲也、中尾敦
  • Industrial Property Rights Holder: 公立大学法人横浜市立大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-09-18
  • Overseas