To develop the effective treatment for hepatic fibrosis using Adipose Tissue-Derived.
| Project/Area Number |
15H05679
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | National Institutes of Biomedical Innovation, Health and Nutrition |
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Principal Investigator |
OKURA Hanayuki 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所 難治性疾患研究開発・支援センター, 研究調整専門員 (20589684)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2017: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2016: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | 脂肪組織由来多系統前駆細胞 / 細胞シート / 肝線維症 / 再生医療 / 再生医学 / 肝硬変 / ADMPC / 肝線維化 / ウイルス性肝炎 / 非ウイルス性肝炎 / 脂肪組織由来鯛系統前駆細胞 |
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| Outline of Final Research Achievements |
As a result of examining cytokine secretion from ADMPC, cytokine having the curative properties of dissolving hepatic fibrosis was secreted in a greater amount than fibroblasts or adipose tissue-derived cells. This mechanism might be Mode-of-Action.
In order to investigate conditions for producing cell sheets, culturing ADMPCs with TGF-β were examined. The efficiency of producing cell sheets were good, but unfortunately the expression of anti-inflammatory cytokines decreased. It was found to be unfavor able for preparing cells for treating to the liver cirrhosis. So, we improved pretreat ment method for temperature sensitive culture dish and increased producing cell sheets efficiency.
When the ADMPC sheets were transplanted into a liver cirrhosis model rats, compared with the control group, the fibrosis rate was significantly improved in the sheet administration group.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Trophic factors from adipose tissue-derived multi-lineage progenitor cells promote cytodifferentiation of periodontal ligament cells.2015
Author(s)
Sawada K., Takedachi M., Yamamoto S., Morimoto C., Ozasa M., Iwayama T., Lee C.M., Okura H., Matsuyama A., Kitamura M., Murakami S.
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Journal Title
Biochem Biophys Res Commun
Volume: Aug 14;464(1)
Issue: 1
Pages: 299-305
DOI
Related Report
Peer Reviewed
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[Presentation] 臨床応用のためのMOAとPOC2018
Author(s)
H Okura, M Morita, M Fujita, K naba, A Matsuyama.
Organizer
World Congress on Toxicology and Pharmacology 2018
Related Report
Int'l Joint Research
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[Presentation] iPS細胞の特許出願動向2017
Author(s)
Y Morita,H Okura,A Matsuyama.
Organizer
International Society for Stem Cell Research 2017
Related Report
Int'l Joint Research
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