The mechanism of cell fate determination in epithelial-mesenchymal interaction during tooth development
| Project/Area Number |
15H05688
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Research Collaborator |
FUKUMOTO Satoshi 東北大学, 歯学研究科, 教授 (30264253)
MIYAZAKI Kanako 九州大学, 大学病院, 助教 (30778840)
ARAI Chieko 九州大学, 大学病院, 研究員 (60802288)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2017: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
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| Keywords | 歯 / 歯原性上皮細胞 / 細胞分化 / 細胞運命決定 / 歯の再生 / 再生医学 / 分化 |
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| Outline of Final Research Achievements |
Epithelial-mesenchymal interaction plays critical roles for the development of organs such as tooth, lung, salivary gland, kidney and hair. During this process, epithelial thickening and budding into mesenchyme are common phenomenon, while the decision of cell fate is made by the specific transcriptional controls of individual organs. In this study, we analyzed the mechanisms of cell fate conversion using mouse model, which generates ectopic hair in tooth. This mouse model also showed enamel hypoplasia in tooth, indicating that the capability of dental cell fate transition into hair cells.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Nephronectin plays critical roles in Sox2 expression and proliferation in dental epithelial stem cells via EGF-like repeat domains2017
Author(s)
Chieko Arai, Keigo Yoshizaki, Kanako Miyazaki, Kan Saito, Aya Yamada, Xue Han, Keita Funada, Emiko Fukumoto, Naoto Haruyama, Tsutomu Iwamoto, Ichiro Takahashi, Satoshi Fukumoto
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Journal Title
Scientific Reports
Volume: 27
Pages: 45181-45181
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Connexin 43 is necessary for salivary gland branching morphogenesis and FGF10-induced ERK1/2 phosphorylation2016
Author(s)
Yamada A, Futagi M, Fukumoto E, Saito K, Yoshizaki K, Ishikawa M, Arakaki M, Hino R, Sugawara Y, Ishikawa M, Naruse M, Miyazaki K, Nakamura T, Fukumoto S.
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Journal Title
The Journal of Biological Chemistry
Volume: 291
Issue: 2
Pages: 904-912
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Plakophilin-1, a novel Wnt signaling regulator, is critical for tooth development and ameloblast differentiation2016
Author(s)
Miyazaki K, Yoshizaki K, Arai C, Yamada A, Saito K, Ishikawa M, Xue H, Funada K, Haruyama N, Yamada Y, Fukumoto S, Takahashi I
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Journal Title
Plos One
Volume: 11
Issue: 3
Pages: 0152206-0152206
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Mutant GDF5 enhances ameloblast differentiation via accelerated BMP2-induced Smad1/5/8 phosphorylation2016
Author(s)
Liu J, Saito K*, Maruya Y, Nakamura T, Yamada A, Fukumoto E, Ishikawa M, Iwamoto T, Miyazaki K, Yoshizaki K, Ge L, Fukumoto S
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Journal Title
Scientific reports
Volume: 6
Issue: 1
Pages: 23670-23670
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Interaction between Fibronectin and β1 Integrin is Essential for Tooth Development.2015
Author(s)
Saito, K., Fukumoto, E., Yamada, A., Yuasa, K., Yoshizaki, K., Iwamoto, T., Saito, M., Nakamura, T., and Fukumoto, S.
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Journal Title
PLOS one
Volume: 10(4)
Issue: 4
Pages: 1-12
DOI
NAID
Related Report
Peer Reviewed / Open Access
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