| Budget Amount *help |
¥174,330,000 (Direct Cost: ¥134,100,000、Indirect Cost: ¥40,230,000)
Fiscal Year 2019: ¥22,620,000 (Direct Cost: ¥17,400,000、Indirect Cost: ¥5,220,000)
Fiscal Year 2018: ¥22,230,000 (Direct Cost: ¥17,100,000、Indirect Cost: ¥5,130,000)
Fiscal Year 2017: ¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
Fiscal Year 2016: ¥61,100,000 (Direct Cost: ¥47,000,000、Indirect Cost: ¥14,100,000)
Fiscal Year 2015: ¥46,020,000 (Direct Cost: ¥35,400,000、Indirect Cost: ¥10,620,000)
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| Outline of Final Research Achievements |
We established an original experimental system to approach the initial process of crystallization. As a result, we found that the key factors controlling the nucleation from the gas phase are decreasing the melting point and the sticking probability of nanoparticles. We also established a transmission electron microscopy for in-situ observation of the nucleation processes from a solution in nanoscale. Then, we elucidated the role of the hydration layer in protein crystallization. For the first time, we have succeeded in directly demonstrating the relationship between nucleation and precursors in terms of the specificity that appears in the nanoscale by handling both vapor and solution phases. Furthermore, we clarified that the understanding of nucleation requires not only the formation of critical nuclei but also the growth beyond the nano-region to stable bulk crystals. Furthermore, we proposed a nucleation model that takes into account the physical properties of the nano-region.
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