| Budget Amount *help |
¥185,900,000 (Direct Cost: ¥143,000,000、Indirect Cost: ¥42,900,000)
Fiscal Year 2019: ¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2018: ¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2017: ¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2016: ¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2015: ¥91,000,000 (Direct Cost: ¥70,000,000、Indirect Cost: ¥21,000,000)
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| Outline of Final Research Achievements |
Most embryonic neural stem cells (NSCs) in the mouse telencephalon lose their ability to produce neurons after producing the required numbers and types of neurons, and produce only glial cells before their extinction. In this study, we focused on the chromatin state of NSCs and identified new factors that regulate neuronal differentiation of NSCs by cooperating with the epigenetic factor Polycomb group proteins. We also narrowed down the population of embryonic origin of adult NSCs that maintain neuronal production capacity and survive into adulthood, and identified transcription factors that may contribute to the establishment and maintenance of the adult NSC lineage.
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