| Budget Amount *help |
¥200,850,000 (Direct Cost: ¥154,500,000、Indirect Cost: ¥46,350,000)
Fiscal Year 2019: ¥29,770,000 (Direct Cost: ¥22,900,000、Indirect Cost: ¥6,870,000)
Fiscal Year 2018: ¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000)
Fiscal Year 2017: ¥29,510,000 (Direct Cost: ¥22,700,000、Indirect Cost: ¥6,810,000)
Fiscal Year 2016: ¥51,480,000 (Direct Cost: ¥39,600,000、Indirect Cost: ¥11,880,000)
Fiscal Year 2015: ¥60,710,000 (Direct Cost: ¥46,700,000、Indirect Cost: ¥14,010,000)
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| Outline of Final Research Achievements |
In this study, we established an exhaustive gene expression analysis method for pathogens in the host environment using next generation sequencer and were able to elucidate in detail the responses of bacteria and fungi to the host environment. We also identified a comprehensive set of virulence factors and successfully identified 20 novel factors in Staphylococcus aureus and more than 30 in Cryptococcus neoformans. We clarified the various functions of these genes in the pathogenicity by biological and genetical methods. Furthermore, we established assay systems for identification of inhibitors for these gene products and identified candidate compounds. These results give novel insight of expression of virulence mechanisms and established a novel method to develop therapeutic options for infectious diseases.
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