| Project/Area Number |
15H06000
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | Hokkaido University |
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Principal Investigator |
ITO KOKI 北海道大学, 大学病院, 助教 (40455663)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | schizophrenia / animal model / psychostimulant / immune / inflammation / microglia / 統合失調症 / 免疫・炎症因子 / 精神刺激薬動物モデル / methamphetamine / マイクログリア / 精神刺激薬モデル / 免疫・炎症 / サンプリング / 免疫組織化学 / 手技の確立 / 蛋白調整 / ウエスタンブロッティング / BCAアッセイ |
|---|
| Outline of Final Research Achievements |
New medicinal methods for schizophrenia with monitoring peripheral immune/inflammation factors have been performed. By using psychostimulant animal model from a point of view of abnormality of immune/inflammation functions, we focus on IL-6, IL1β, TNFα, IFNγ, and microgrial hyperactivity in prefrontal cortex. Our animal model is shown to be useful for researching schizophrenia, and we may suggest the three new approaches with medication. First are drugs that indirectly improve peripheral abnormality of immune/inflammation factors, including even they can not go through brood brain barrier. Second are drugs that can directly recover above factors in the brain that have no action on neuron. The last are that can suppress microgrial activity in the brain.
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