| Project/Area Number |
15H06045
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Tohoku University |
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Principal Investigator |
Kamano Yuya 東北大学, 大学病院, 助教 (70757260)
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| Research Collaborator |
EGUSA Hiroshi 東北大学, 大学院歯学研究科, 教授
SAEKI Makio 新潟大学, 大学院医歯薬総合研究科, 教授
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 骨代謝 / グルタミン酸受容体 / 再生医学 / 細胞・組織 / 歯学 / シグナル伝達 / 骨芽細胞分化 / グルタミン酸レセプター / PICK1 |
|---|
| Outline of Final Research Achievements |
For severe bone resorption, the development of new therapeutic methods based on the regulate bone metabolism factors is an important issue. In this study, we focused on glutamate, which is a neurotransmitter that has the role of regulating bone metabolism, so we studied PICK1 which bind to AMPA glutamate receptor.
Over-expression of PICK1 significantly promoted osteoclast differentiation of osteoclast precursor cells and PDZ domain binding inhibitor of PICK1 significantly inhibited osteoclast differentiation. On the other hand, over-expression of PICK1 of osteoblast precursor cells did not affect osteoblast differentiation.
From the above, it is suggested that PICK1 does not affect osteoblast differentiation and regulate osteoclast differentiation.
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