Development of method for generation of iPS cell-derived odontogenic cells by gene transfection
| Project/Area Number |
15H06048
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SEKI DAISUKE 東北大学, 歯学研究科, 助教 (90758442)
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| Research Collaborator |
TAKESHITA NOBUO 東北大学, 大学院歯学研究科, 助教 (50431515)
YAMAMOTO TERUKO 東北大学, 大学院歯学研究科, 名誉教授 (00127250)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | iPS細胞 / 歯 / 再生医療 |
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| Outline of Final Research Achievements |
We aimed to induce odontogenic cells from induced pluripotent stem cells (iPS cells) by gene transfection. To induce dental epithelial-like cells, we first generated iPS cell-derived epithelial cells. Next, we transfected essential factor of odontogenesis into iPS cell-derived neural crest like cells. Transfection efficiency was evaluated using flow cytometry.
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Report
(3 results)
Research Products
(9 results)
