Synthesis of Novel Functional Cyanidin Glycosides
| Project/Area Number |
15H06076
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biomolecular chemistry
|
|---|
| Research Institution | Gunma University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | シアニジン / 配糖体 / 糖鎖化学合成 / 糖鎖酵素合成 / 抗酸化作用 / 非天然型糖鎖修飾 / 糖鎖 / 糖転移酵素 / 生体分子 / 合成化学 / 糖 / 化学合成 / 酵素合成 |
|---|
| Outline of Final Research Achievements |
Cyanidin is one of flavonoid pigments distributed in a wide range of plants. Because of its effective bioactivities (e.g. antioxidant activity, inhibition of malignant cell growth et al.), Cyanidin has been recognized as a valuable compound in light of health promotion. In nature, Cyanidin is existing as glycosides and these glycan parts are confirmed their effects on molecular stability and enhancement of bioactivity. In this project, we chemically/enzymatically synthesized novel Cyanidin glycosides modified with non-native sugars (Lactose, 3-fluoro Glucose and Sialylated Lactose) onto 3-OH position. These synthesized Cyanidin glycosides were examined their antioxidant activity by ORAC assay. As a result, we found that modification with non-native type sugars on Cyanidin gave better antioxidant activity compared to natural type Cyanidin and its glycosides.
|
Report
(3 results)
Research Products
(3 results)
