| Budget Amount *help |
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The secreted glycoprotein MFG-E8 has many functions, including accelerating phagocytosis of apoptotic cells by phagocytes and promoting angiogenesis. We previously reported that administration of MFG-E8 suppresses the formation of pressure ulcers induced by cutaneous ischemia-reperfusion(I/R) injury by regulating inflammation and angiogenesis. It has been reported that Mesenchymal stem cells (MSC) has the potential preventing tissue damage caused by I/R injury in several organs including brain, liver and kidney. Furthermore, we recently investigated that MSC produce large amount of MFG-E8, however, the precise mechanism of MSC-derived MFG-E8 in cutaneous I/R injury was not well known.
The aim of this study is to elucidate the mechanisms and the roles of MSC in cutaneous I/R injury involving the regulation of apoptotic cells, inflammatory reaction and angiogenesis, and the effect of MSC-derived MFG-E8 on I/R injury.
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