Design, Synthesis and Functional Analysis of Ion-Channel-Forming Molecules Based on Polytheonamide Structure
| Project/Area Number |
15H06156
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Itoh Hiroaki 東京大学, 大学院薬学系研究科(薬学部), 助教 (20758205)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 固相合成 / 有機化学 / 合成化学 / ペプチド / イオンチャネル / 脂質 |
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| Outline of Final Research Achievements |
Polytheonamide B is an ion-channel-forming 48-mer natural peptide that displays extraordinarily potent cytotoxicity. This study focuses on establishment of highly efficient solid-phase synthetic strategy for detailed functional and biological investigations of polytheonamide B and its analogues. Novel strategy of protective groups for component amino acids enabled full solid-phase total synthesis of polytheonamide B and its analogues. The newly established synthetic strategy significantly reduced the number of solution-phase synthetic steps and HPLC purification steps, leading to the efficient and facile synthesis of the total structure of polytheonamide B.
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Report
(3 results)
Research Products
(11 results)
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[Presentation] ヤクアミドBの固相全合成2017
Author(s)
神谷光一、山下智也、伊藤寛晃、井上将行
Organizer
日本薬学会 第137年会
Place of Presentation
東北大学(宮城県・仙台市)
Year and Date
2017-03-24
Related Report
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