Evaluation and prediction approach of cumulative dose distributions in consideration of structural change during radiotherapy.

• Project/Area Number: 15H06168
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: The University of Tokyo
• Principal Investigator: Takahashi Wataru 東京大学, 医学部附属病院, 助教 (50755668)
• Research Collaborator: NAKAGAWA Keiichi ; YAMASHITA Hideomi ; HAGA Akihiro ; NAWA Kanabu ; SAKUMI Akira ; IMAE Toshikazu ; TAKENAKA Shigeharu ; MAGOME Taiki ; NAKANO Masahiro
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 放射線治療 / 放射線

Outline of Final Research Achievements

For patients with small lung tumor treated with intensity modulated radiation therapy, we established methodology for estimating actual delivered dose distributions taking account for respiratory motion. Based on logs including gantry angle, monitor unit, and the position of multi-leaf collimators during beam delivery, actual dose distribution on each respiratory phase was calculated. Then, accumulated dose distribution was simulated using deformable image registration. The present method successfully reconstructed accumulated dose distribution. The difference between this simulated dose and planning dose was reported in academic conference and will be reported as academic article.

Research Products

• [Journal Article] Long-term outcomes of single-session stereotactic radiosurgery for cerebellar arteriovenous malformation, with a median follow up of 10 years. (2017)
  • Author(s): Hasegawa H, Hanakita S, Shin M, Shojima M, Koga T, Takahashi W, Sakuramachi M, Nomoto AK, Saito N.
  • Journal Title: World Neurosurg. Volume: 98 Pages: 314-322
  • Peer Reviewed
• [Journal Article] Clinical Value of the Epstein-Barr Virus and p16 Status in Patients with Nasopharyngeal Carcinoma: A Single-Centre Study in Japan. (2017)
  • Author(s): Saito Y, Ushiku T, Omura G, Yasuhara K, Yoshida M, Takahashi W, Ando M, Fukayama M, Yamasoba T
  • Journal Title: ORL J Otorhinolaryngol Relat Spec. Volume: 78(6) Issue: 6 Pages: 334-343
  • DOI: 10.1159/000455901
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Contrast media-assisted in-treatment cone beam CT during single-isocentre volumetric-modulated arc therapy for multiple brain metastases: a case study. (2016)
  • Author(s): Nomoto AK, Takahashi W (Corresponding Author), Yamashita H, Haga A, Yoda K, Nakagawa K
  • Journal Title: BJR Case Rep Volume: 3(1) Pages: 20160088-20160088
  • DOI: 10.1016/j.wneu.2016.10.137
  • Peer Reviewed / Open Access
• [Journal Article] Induction Chemotherapy for p16 Positive Oropharyngeal Squamous Cell Carcinoma (2016)
  • Author(s): Yuki Saito, MD, PhD; Mizuo Ando, MD, PhD; Go Omura, MD; Kazuo Yasuhara, MD; Masafumi Yoshida, MD, PhD; Wataru Takahashi, MD, PhD; Tatsuya Yamasoba, MD, PhD
  • Journal Title: Laryngoscope Investigative Otolaryngology Volume: 未定
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Evaluation of a Post-analysis Method for Cumulative Dose Distribution in Stereotactic Body Radiotherapy (2016)
  • Author(s): 今江 禄一, 芳賀 昭弘, 早乙女 直也, 木田 智士, 中野 正寛, 竹中 重治, 竹内 幸浩, 白木 尚, 矢野 敬一, 山下 英臣, 中川 恵一, 大友 邦
  • Journal Title: Japanese Journal of Radiological Technology Volume: 72 Issue: 3 Pages: 251-260
  • DOI: 10.6009/jjrt.2016_JSRT_72.3.251
  • NAID: 130005137459
  • ISSN: 0369-4305, 1881-4883
  • Peer Reviewed / Open Access
• [Presentation] Changes in pulmonary function after single fraction carbon ion radiotherapy for stage I NSCLC (2016)
  • Author(s): W. Takahashi, N. Yamamoto, M. Nakajima, M. Karube, H. Yamashita, K. Nakagawa, H. Tsuji, T. Kamada
  • Organizer: ESTRO 35
  • Place of Presentation: Turin（Italy）
  • Year and Date: 2016-04-29
  • Int'l Joint Research
• [Presentation] Definitive Radiotherapy for Early Stage (cT1-T2) Glottic Squamous Cell Carcinoma: the University of Tokyo Hospital Experience (2016)
  • Author(s): W. Takahashi, R. Kobayashi, M. Sakuramachi, T. Kiritoshi, K. Yamamoto, H. Igaki, H. Yamashita, and K. Nakagawa
  • Organizer: 第75回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県・横浜市)
  • Year and Date: 2016-04-14
• [Presentation] FFF-VMAT-SBRTにおける 非剛体レジストレーションを用いた4次元線量解析 (2016)
  • Author(s): 髙橋 渉, 今江 禄一, 竹中 重治, 山下 英臣, 中川 恵一, 芳賀 昭弘
  • Organizer: 日本放射線腫瘍学会第29回学術大会
  • Place of Presentation: 国立京都国際会館（京都）
• [Presentation] Definitive Radiotherapy for Early Stage (cT1-T2) Glottic Squamous Cell Carcinoma: the University of Tokyo Hospital Experience (2016)
  • Author(s): 髙橋 渉, 山下 英臣, 櫻町 円香、中川 恵一
  • Organizer: 第75回日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（神奈川）