Molecular mechanism of uptake of Methionine for malignant glioma

Research Project

Project/Area Number	15H06187
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Neurosurgery
Research Institution	Tokyo Medical and Dental University
Principal Investigator	Sumita Kazutaka 東京医科歯科大学, 医学部附属病院, 助教 (70752830)
Project Period (FY)	2015-08-28 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	悪性神経膠腫 / PET / メチオニン / 神経膠腫
Outline of Final Research Achievements	When I performed the surgery for malignant glioma in 2015 and 2016, I removed the part of tumors that MET-PET accumulated using navigation system. I took the 15 pieces of tumor of five patients in this study period. mRNA expression of these samples was analyzed by RNA sequence. I found the candidate of the targets of the treatment. One of them is the enzyme of metabolic pathway of Guanosine triphosphate. The inhibitor of this enzyme cause cell cycle arrest, and I am focusing on the mechanism of cell cycle arrest. I will examine the clinical application of this drug in future.