Periodontal tissue regeneration using controlled release of fibroblast growth factor-2 by electrostatic binding with scaffold
| Project/Area Number |
15H06190
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
hoshi shu 東京医科歯科大学, 歯学部附属病院, 非常勤講師 (70757210)
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| Research Collaborator |
AKIZUKI Tatsuya
MATSURA Takanori
IZUMI Yuichi
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 線維芽細胞増殖因子-2 / 徐放化 / 歯周組織再生 / 歯周病 / FGF-2 / 歯学 / 再生医学 / 再生 / 細胞増殖因子 |
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| Outline of Final Research Achievements |
Experiments were carried out on periodontal defect model using beagle dogs. Controlled release of fibroblast growth factor-2 by electrostatic binding with β-TCP acidic gelatin sponge was effective in root cover to gingival recession. Combined use of acidic β-TCP gelatin sponge and fibroblast growth factor-2 was effective for regenerating alveolar bone compared to the combination of basic β-TCP gelatin sponge and fibroblast growth factor-2.In periodontal tissue regeneration therapy, the combination of β-TCP gelatin sponge and fibroblast growth factor-2 was not effective compared with the combination of β-TCP particles and fibroblast growth factor-2.
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Report
(3 results)
Research Products
(4 results)
