Basic research into effective care for promoting cutaneous wound healing -Selecting the optimal application method-

• Project/Area Number: 15H06236
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Fundamental nursing
• Research Institution: Kanazawa University
• Principal Investigator: MUKAI Kanae 金沢大学, 保健学系, 助教 (30755335)
• Project Period (FY): 2015-08-28 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 細胞・組織 / 皮膚創傷治癒 / エストロゲン

Outline of Final Research Achievements

The aim of this study was to compare the effects of the topical application of estradiol benzoate (EB) to wounds with the standard treatment methods. The wound area ratios of the topical EB wound treatment group were significantly smaller than those of the subcutaneous E2 pellet group on days 1-14 and the topical E2 skin application group on days 1-9. Significantly lower numbers of neutrophils and macrophages were seen in the topical EB wound treatment group than in the subcutaneous E2 pellet and topical E2 skin application groups on day 7. Moreover, the number of new blood vessels and the ratio of myofibroblasts were significantly higher in the topical EB wound treatment group than in the subcutaneous E2 pellet and topical E2 skin application groups on day 7. These results indicate that the application of EB to wounds significantly reduces the inflammatory response and promotes wound contraction and angiogenesis compared with the other two standard treatment methods.

Research Products

• [Journal Article] 未経験者による三角筋筋肉内注射の位置決め器具の使用に関する正確性と簡便性の生体での検討 (2016)
  • Author(s): 向井加奈恵、小松恵美、中島由加里、浦井珠恵、浅野きみ、中谷壽男
  • Journal Title: 形態機能 Volume: 14 Pages: 75-83
  • NAID: 130005144368
  • Peer Reviewed
• [Presentation] Evaluation of the effect of estradiol benzoate on cutaneous wound healing in ovariectomized female mice -Focus on the inflammatory response- (2016)
  • Author(s): Kanae Mukai, Tamae Urai, Kimi Asano, Yukari Nakajima, Toshio Nakatani
  • Organizer: ＷＵＷＨＳ 2016
  • Place of Presentation: イタリア フィレンツェ
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] Effects of honeydew honey on wound healing (2016)
  • Author(s): Yukari Nakajima, Kanae Mukai, Tamae Urai, Kimi Asano, Megumi Ohta, Ikuko Kato, Azusa Kawaguchi, Yui Kinoshita, Yuri Kumagai, Ayaka Sakashita, Takuto Sawazaki, Asuka Yamazaki, Toshio Nakatani
  • Organizer: ＷＵＷＨＳ 2016
  • Place of Presentation: イタリア フィレンツェ
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] A comparative study of skin bacterial communities in healthy-young individuals and bedridden-aged inpatients in Japan (2016)
  • Author(s): Ogai Kazuhiro, Nagase Satoshi, Mukai Kanae, Iuchi Terumi, Okamoto Shigefumi, Sugama Junko
  • Organizer: ＷＵＷＨＳ 2016
  • Place of Presentation: イタリア フィレンツェ
  • Year and Date: 2016-09-25
  • Int'l Joint Research
• [Presentation] 寝たきり高齢入院患者と若年健常人における皮膚細菌叢の比較 (2016)
  • Author(s): 長瀬 賢史、大貝 和裕、向井 加奈恵、岡本 成史、須釜 淳子
  • Organizer: 第58回日本老年医学会学術集会
  • Place of Presentation: 石川県立音楽堂、ANAクラウンプラザホテル金沢、金沢市アートホール（石川県金沢市）
  • Year and Date: 2016-06-08
• [Presentation] Estradiol benzoateの創部塗布による皮膚創傷治癒への効果ー肉眼的検討ー (2015)
  • Author(s): 向井加奈恵、浦井珠恵、浅野きみ、中島由加里、須釜淳子、中谷壽男
  • Organizer: 第45回日本創傷治癒学会学術集会
  • Place of Presentation: ＪＲタワーホール＆カンファレンス（東京都千代田区）
  • Year and Date: 2015-11-30
• [Presentation] 鼡径リンパ節を郭清した下腿に作製した創傷は治癒が遅延するか (2015)
  • Author(s): 中谷壽男、小松恵美、浅野きみ、向井加奈恵、浦井珠恵、中島由加里
  • Organizer: 第45回日本創傷治癒学会
  • Place of Presentation: ＪＲタワーホール＆カンファレンス（東京都千代田区）
  • Year and Date: 2015-11-30
• [Remarks] 所属研究グループのウェブサイト
  • URL: http://wmn.w3.kanazawa-u.ac.jp/