Evaluation of autoinflammatory responses in mouse cochlea
| Project/Area Number |
15H06255
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 蝸牛 / 免疫応答 |
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| Outline of Final Research Achievements |
NLRP3 protein is expressed in innate immune cells including macrophages. Gain of function mutations of NLRP3 induce the activation of NLRP3 inflammasome, resulting in the secretion of proinflammatory cytokine, interleukin-1 beta, to cause systemic inflammatory diseases, cryopyrin associated periodic syndromes. We found that a gain of function mutation of NLRP3 also caused non-syndromic hearing loss. We hypothesized that the hearing loss was caused by the activation of NLRP3 inflammasome mainly in the cochleae. We revealed that tissue-resident macrophage-like cells existed and mRNAs consisting NLRP3 inflammasome were expressed in the wild type mouse cochleae.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] TMC1 and TMC2 localize at the site of mechanotransduction in mammalian inner ear hair cell stereocilia.2015
Author(s)
Kurima K, Ebrahim S, Pan B, Sedlacek M, Sengupta P, Millis B, Cui R, Nakanishi H, Fujikawa T, Kawashima Y, Choi BY, Monahan K, Holt JR, Griffith AJ, Kachar B
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Journal Title
Cell Report
Volume: 12
Issue: 10
Pages: 1606-1617
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] NLRP3 mutation and cochlear autoinflammation cause syndromic and nonsyndromic hearing loss DFNA342017
Author(s)
Nakanishi H, Kawashima Y, Kurima K, Chae JJ, Ross AM, Pinto-Patarroyo G, Patel SK, Muskett JA, Ratay JS, Chattaraj P, Grevich S, Brewer CC, Hoa M, Kim HJ, Butman JA, Broderick L, Hoffman HM, Aksentijevich I, Kastner DL, Goldbach-Mansky R, Griffith AJ
Organizer
ARO 40th Annual MidWinter Meeting
Place of Presentation
Baltimore Marriott Waterfront
Year and Date
2017-02-11
Related Report
Int'l Joint Research
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[Presentation] 先天性外耳道鼓膜真珠腫例2016
Author(s)
中西啓，遠藤志織，大和谷崇，水田邦博，峯田周幸
Organizer
第11回日本小児耳鼻咽喉科学会総会・学術講演会
Place of Presentation
ホテルクレメント徳島
Year and Date
2016-06-30
Related Report
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[Presentation] 高齢者の耳管開放症例2016
Author(s)
中西啓，水田邦博，遠藤志織，大和谷崇，峯田周幸
Organizer
第78回耳鼻咽喉科臨床学会総会・学術講演会
Place of Presentation
城山観光ホテル
Year and Date
2016-06-23
Related Report
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