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The exploration of the order in the heterogeneity of prostate cancer-associated stroma environment

Research Project

Project/Area Number 15H06289
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionMie University

Principal Investigator

KATO Manabu  三重大学, 医学部附属病院, 助教 (60626117)

Project Period (FY) 2015-08-28 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords前立腺癌関連線維芽細胞 / 不均一性 / Heterogeneity / 細胞表面マーカー / 癌関連線維芽細胞 / CD105 / FACS / 去勢抵抗性前立腺癌 / 前立腺癌 / 上皮と間質の相互作用 / 線維芽細胞
Outline of Final Research Achievements

We demonstrated that each cancer-associated fibroblsts (CAFs) from different patients expressed diverse cell surface markers such as Stro-1, CD117, CD105 in different ratio. In in vivo, tumor formation assay using one of prostate epithelial cell, 22RV1 mixed with CAFs showed that CD105 neutrilizing reagent suppress this tumor growth dynamically. In addition, 22RV1 had property to change in castration-resistant prostate cancer treated with anti-androgen drug, and made tumor once they cultured in vivo with CAFs. CD105 neutralizing reagent could suppress these tumor also. It seemed that manuplating cell surface markers on CAFs or epithelial cells might be basic strategy to treat cancer assosiated fibroblast, in tumor microenvironment, thus could be treatment for prostate cancer.

Report

(3 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • Research Products

    (4 results)

All 2016

All Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] 前立腺の基礎研究を通して得られた泌尿器科臨床における新たな視点2016

    • Author(s)
      加藤 学
    • Organizer
      第66回 日本泌尿器科学会中部総会
    • Place of Presentation
      四日市市文化会館、四日市都ホテル(三重県、四日市市)
    • Year and Date
      2016-10-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] The exploration of the order in the heterogeneity of prostate cancer-associated stroma environment2016

    • Author(s)
      Manabu Kato
    • Organizer
      111st American Urological Association Association Annual meeting
    • Place of Presentation
      サンディエゴコンベンションセンター (米国、カリフォルニア州、サンディエゴ)
    • Year and Date
      2016-05-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] The exploration of the order in the heterogeneity of prostate cancer-associated stroma environment2016

    • Author(s)
      Manabu Kato
    • Organizer
      American Urological Association, Annual meeting 2016
    • Place of Presentation
      Sandiego, U.S.
    • Year and Date
      2016-05-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 細胞表面タンパクによる前立腺癌間質細胞の不均一性の検討2016

    • Author(s)
      加藤 学
    • Organizer
      第104回 日本泌尿器科学会総会
    • Place of Presentation
      仙台国際センター、東北大学(川内キャンパス) (宮城県、仙台市)
    • Year and Date
      2016-04-23
    • Related Report
      2016 Annual Research Report

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Published: 2015-08-26   Modified: 2018-03-22  

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