Elucidation of the upstream regulatory mechanism of UCHL1-HIF-1 pathway in cancer microenvironment and development of the pathway for enhancing radiosensitivity
| Project/Area Number |
15H06337
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
Goto Yoko 京都大学, 医学研究科, 助教 (60755651)
|
|---|
| Project Period (FY) |
2015-08-28 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 放射線治療 / 低酸素 / HIF-1 / UCHL1 / 悪性腫瘍 |
|---|
| Outline of Final Research Achievements |
Cancer cells under hypoxic environment activate hypoxia-inducible factor (HIF-1), resulting in enhancing malignant phenotype. We identified UCHL1 as a novel upstream activator of HIF-1 through an original genetic screening strategy. Furthermore, we revealed that the UCHL1-HIF-1 pathway is responsible for distant metastasis of cancer and leads to poor prognosis of cancer patients. In this study, we aimed to elucidate the upstream regulatory mechanisms of the UCHL1-HIF-1 pathway. In addition, we elucidated that UCHL1-HIF-1 pathway contribute to radioresistance of cancer cells via metabolic reprogramming and proved a rational basis for targeting this pathway for radiosensitization.
|
Report
(3 results)
Research Products
(3 results)
