Role of T cells during stem cell-driven regeneration: towards design of efficient stem cell-based therapies
| Project/Area Number |
15H06348
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka University |
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Principal Investigator |
MARTINO Mikael (Martino Mikael) 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (30741293)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Declined (Fiscal Year 2016)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 再生医療 / 免疫学 / 幹細胞 / T細胞 / バイオマテリアル |
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| Outline of Annual Research Achievements |
As we are facing an aging population, regenerative medicine will play a key role in patient care. While the field is becoming one of the next major innovations in healthcare, clinical translations of therapies are often very modest. For this research project, I hypothesized that tissue regeneration is strongly regulated by a crosstalk between the adaptive immune system and tissue-resident stem cells. Specifically, subsets of T cells could act as either “antiregenerative” or as “proregenerative”, by regulating stem cell functions.
One the main goal for FY2015 was to determine which types of T cells and when are they recruited during stem cell-driven tissue healing. Using a bone regeneration model in the mouse, I found that T cells are recruited about 10 days following bone injury. The number of T cell is higher when the defects are treated with mesenchymal stem cells, especially the number of regulatory T cells.
The second goal was to determine whether T cells modulate stem cell-driven tissue healing. I found that mice with more regulatory T cells (regulatory T cells injected i.v.) significantly regenerate bone faster. In addition, when defect are treated with mesenchymal stem cells, mice with more regulatory T cells significantly regenerate bone faster.
The results of this research will serve as a base to design novel stem cell-based therapies.
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| Research Progress Status |
翌年度、交付申請を辞退するため、記入しない。
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| Strategy for Future Research Activity |
翌年度、交付申請を辞退するため、記入しない。
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Report
(1 results)
Research Products
(3 results)
