The mechanism of circadian expression of neuromedin U in the pars tuberalis.

Research Project

Project/Area Number	15H06419
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Morphology/Structure
Research Institution	Okayama University
Principal Investigator	AIZAWA SAYAKA 岡山大学, 自然科学研究科, 特別契約職員(助教) (90754375)
Project Period (FY)	2015-08-28 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	下垂体隆起部 / 概日時計 / 生物リズム / 下垂体 / 隆起部 / ニューロメジンU / メラトニン / ラット
Outline of Final Research Achievements	The regulatory mechanism of the expression of neuromedin U (NMU) in the rat pars tuberalis. Quantitative PCR showed that melatonin receptor MT1a and adenosine receptor A2b are highly expressed in the rat pars tuberalis. In rat brain slice culture experiment, NMU mRNA expression was significantly suppressed by melatonin and significantly increased by adenosine. It is suggested that diurnal rhythm expression of NMU in the rat pars tuberalis is antagonistically regulated by adenosine and melatonin.

Report

(3 results)