Study on asthma-like airway inflammation by composition of PM 2.5

• Project/Area Number: 15H06422
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Hygiene and public health
• Research Institution: Okayama University
• Principal Investigator: NAGAOKA KENJIRO 岡山大学, 医歯薬学総合研究科, 助教 (40752374)
• Research Collaborator: OGINO KEIKI ; KUBO MASAYUKI ; NAKAYAMA SHOJI
• Project Period (FY): 2015-08-28 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 浮遊粒子状物質 / PM2.5 / 大気汚染 / アレルギー性気道炎症 / 健康影響

Outline of Final Research Achievements

In this study, we examined how the change of the composition of PM 2.5 by region and time affects. PM 2.5 was collected in various regions and periods, and component analysis was conducted. It was found that the composition varies depending on the area. In the cell exposure, an increase in cytokine mRNA amount was observed depending on PM 2.5 concentration. Although there was no significant difference, there was a tendency for gene expression to change between regions.. The occurrence of allergic airway inflammation may be influenced by differences in composition by area or time.

Research Products

• [Journal Article] PM2.5-induced airway inflammation and hyperresponsi-veness in NC/Nga mice (2017)
  • Author(s): Ogino K, Nagaoka K, Okuda T, Oka A, Kubo M, Eguchi E, Fujikura Y
  • Journal Title: Environmental Toxicology Volume: 32 Issue: 3 Pages: 1047-1054
  • DOI: 10.1002/tox.22303
  • Peer Reviewed / Open Access
• [Journal Article] PM2.5によるアレルギー性気道炎症 (2015)
  • Author(s): 荻野景規, 長岡憲次郎, 久保正幸
  • Journal Title: THE LUNG perspectives Volume: 23 Pages: 387-390
• [Presentation] 本邦初のPM2.5による喘息実験の成功とそのメカニズム-PM2.5組成との関連性 (2017)
  • Author(s): 長岡憲次郎, 荻野景規, 伊藤達男
  • Organizer: 第87回日本衛生学会学術集会
  • Place of Presentation: フェニックス・シーガイア・リゾート(宮崎県宮崎市）
  • Year and Date: 2017-03-26
• [Presentation] PM2.5による喘息の発症～組成による発生機序～ (2016)
  • Author(s): 荻野景規, 長岡憲次郎, 伊藤達男
  • Organizer: 第86回日本衛生学会学術総会
  • Place of Presentation: 旭川市民文化会館(北海道旭川市）
  • Year and Date: 2016-05-11
• [Presentation] PM2.5とタンパク質 (2015)
  • Author(s): 荻野景規, 長岡憲次郎, 久保正幸, 岡瑛良, 江口依里, 尾長谷靖, 藏満保宏
  • Organizer: 第25回日本産業衛生学会 産業医・産業看護全国協議会 合同開催 第24回産業衛生技 術部会大会
  • Place of Presentation: 周南市文化会館 (山口県周南市)
  • Year and Date: 2015-09-18