| Project/Area Number |
15H06450
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | The University of Tokushima |
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Principal Investigator |
INOUE Miho 徳島大学, 大学院医歯薬学研究部(歯学系), 助教 (20271059)
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| Project Period (FY) |
2015-08-28 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 幹細胞化 / 骨芽細胞様細胞 / 骨髄細胞 / 骨芽細胞 / 分化 / 歯学 / 生体材料 |
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| Outline of Final Research Achievements |
TNF-a is known as one of inflammatory cytokine causing bone resorption, claim and edema of the organization. On the other hand, it was revealed that the TNF participated in an anagenesis by the wound healing process. A study about effect of TNF-a on human dental pulp cell differentiation was carried out in our laboratory in the past. Dental pulp cells are cell group including such as stem cell, primary odontoblast and fibroblast. It was revealed that the ratios of stem cells in the pulp cell increased by stimulation of TNF-a. The purpose of this study was investigated the effect of a short term stimulated TNF-a in osteoblast and bone marrow cells. The cell proliferation was no significant difference between stimulated TNF-a and no stimulation (control). On the other hand, cell differentiation was inhibited the cells of stimulation of TNF-a. In future, we have investigated of the signaling mechanism of a short term stimulated TNF-a.
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